SARS-CoV CH.1.1 Variant: Genomic and Structural Insight

Detalhes bibliográficos
Autor(a) principal: Bazzani, Liliana
Data de Publicação: 2023
Outros Autores: Imperia, Elena, Scarpa, Fabio, Sanna, Daria, Casu, Marco, Borsetti, Alessandra, Pascarella, Stefano, Petrosillo, Nicola, Cella, Eleonora, Giovanetti, Marta, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59592
Resumo: Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy
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spelling Bazzani, LilianaImperia, ElenaScarpa, FabioSanna, DariaCasu, MarcoBorsetti, AlessandraPascarella, StefanoPetrosillo, NicolaCella, EleonoraGiovanetti, MartaCiccozzi, Massimo2023-07-14T13:11:16Z2023-07-14T13:11:16Z2023BAZZANI, Liliana et al. SARS-CoV CH.1.1 Variant: Genomic and Structural Insight. Infectious disease reports, v. 15, n. 3, p. 292-298, 2023. doi.org/10.3390/idr15030029.2036-7430https://www.arca.fiocruz.br/handle/icict/59592engMDPISARS-CoV CH.1.1 Variant: Genomic and Structural Insightinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, ItalyUnit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy/Unit of Gastroenterology. Department of Medicine. University Campus Bio-Medico of Rome. Rome, ItalyDepartment of Biomedical Sciences. University of Sassari. Sassari, ItalyDepartment of Biomedical Sciences. University of Sassari. Sassari, ItalyDepartment of Veterinary Medicine. University of Sassari. Sassari, ItalyNational HIV/AIDS Research Center. National Institute of Health. Rome, ItalyDepartment of Biochemical Sciences “A. Rossi Fanelli”. Sapienza University of Rome, Rome, ItalyInfection Prevention and Control—Infectious Disease Service. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, ItalyBurnett School of Biomedical Sciences. University of Central Florida. Orlando, FL, USASciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, BrazilUnit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, ItalyIn early February 2023, the Omicron subvariant XBB.1.5, also known as “Kraken”, accounted for more than 44% of new COVID-19 cases worldwide, whereas a relatively new Omicron subvariant named CH.1.1, deemed “Orthrus”, accounted for less than 6% of new COVID-19 cases during the subsequent weeks. This emerging variant carries a mutation, L452R, previously observed in the highly pathogenic Delta and the highly transmissible BA.4 and BA.5 variants, necessitating a shift to active surveillance to assure adequate preparedness for likely future epidemic peaks. We provide a preliminary understanding of the global distribution of this emerging SARS-CoV-2 variant by combining genomic data with structural molecular modeling. In addition, we shield light on the number of specific point mutations in this lineage that may have functional significance, thereby increasing the risk of disease severity, vaccine resistance, and increased transmission. This variant shared about 73% of the mutations with Omicron-like strains. Our homology modeling analysis revealed that CH.1.1 may have a weakened interaction with ACE2 and that its electrostatic potential surface appears to be more positive than that of the reference ancestral virus. Finally, our phylogenetic analysis revealed that this likely-emerging variant was already cryptically circulating in European countries prior to its first detection, highlighting the importance of having access to whole genome sequences for detecting and controlling emerging viral strainsCH.1.1 variantgenomic surveillanceSARS-CoV-2mutational pattern profileinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59592/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSARS-CoV CH.1.1 Variant_ Genomic and Structural Insight.pdfSARS-CoV CH.1.1 Variant_ Genomic and Structural Insight.pdfapplication/pdf1653217https://www.arca.fiocruz.br/bitstream/icict/59592/2/SARS-CoV%20CH.1.1%20Variant_%20Genomic%20and%20Structural%20Insight.pdfc0c6201bdae2adc06e20c2d4ae714122MD52icict/595922023-07-14 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dc.title.en_US.fl_str_mv SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
title SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
spellingShingle SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
Bazzani, Liliana
CH.1.1 variant
genomic surveillance
SARS-CoV-2
mutational pattern profile
title_short SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
title_full SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
title_fullStr SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
title_full_unstemmed SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
title_sort SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
author Bazzani, Liliana
author_facet Bazzani, Liliana
Imperia, Elena
Scarpa, Fabio
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Pascarella, Stefano
Petrosillo, Nicola
Cella, Eleonora
Giovanetti, Marta
Ciccozzi, Massimo
author_role author
author2 Imperia, Elena
Scarpa, Fabio
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Pascarella, Stefano
Petrosillo, Nicola
Cella, Eleonora
Giovanetti, Marta
Ciccozzi, Massimo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bazzani, Liliana
Imperia, Elena
Scarpa, Fabio
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Pascarella, Stefano
Petrosillo, Nicola
Cella, Eleonora
Giovanetti, Marta
Ciccozzi, Massimo
dc.subject.en.en_US.fl_str_mv CH.1.1 variant
genomic surveillance
SARS-CoV-2
mutational pattern profile
topic CH.1.1 variant
genomic surveillance
SARS-CoV-2
mutational pattern profile
description Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-07-14T13:11:16Z
dc.date.available.fl_str_mv 2023-07-14T13:11:16Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BAZZANI, Liliana et al. SARS-CoV CH.1.1 Variant: Genomic and Structural Insight. Infectious disease reports, v. 15, n. 3, p. 292-298, 2023. doi.org/10.3390/idr15030029.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59592
dc.identifier.issn.en_US.fl_str_mv 2036-7430
identifier_str_mv BAZZANI, Liliana et al. SARS-CoV CH.1.1 Variant: Genomic and Structural Insight. Infectious disease reports, v. 15, n. 3, p. 292-298, 2023. doi.org/10.3390/idr15030029.
2036-7430
url https://www.arca.fiocruz.br/handle/icict/59592
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59592/1/license.txt
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