Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.

Detalhes bibliográficos
Autor(a) principal: Alvarez, Luis Carlos Salazar
Data de Publicação: 2023
Outros Autores: Barbosa, Vanessa Carneiro, Lizcano, Omaira Vera, Silva, Djane Clarys Baia da, Santana, Rosa Amélia Gonçalves, Fabbri, Camila, Pimenta, Paulo Filemon Paoluci, Monteiro, Wuelton Marcelo, Albrecht, Letusa, Lacerda, Marcus Vinicius Guimarães de, Costa, Fabio Trindade Maranhão, Lopes, Stefanie Costa Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57395
Resumo: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil.
id CRUZ_3334a198bc80a37a13abe7753492ee5a
oai_identifier_str oai:www.arca.fiocruz.br:icict/57395
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Alvarez, Luis Carlos SalazarBarbosa, Vanessa CarneiroLizcano, Omaira VeraSilva, Djane Clarys Baia daSantana, Rosa Amélia GonçalvesFabbri, CamilaPimenta, Paulo Filemon PaoluciMonteiro, Wuelton MarceloAlbrecht, LetusaLacerda, Marcus Vinicius Guimarães deCosta, Fabio Trindade MaranhãoLopes, Stefanie Costa Pinto2023-03-15T19:34:20Z2023-03-15T19:34:20Z2023SALAZAR ALVAREZ, Luis Carlos et al. Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis. Frontiers in Cellular and Infection Microbiology, v. 13, 1108348, p. 1-7, 2023.2235-2988https://www.arca.fiocruz.br/handle/icict/5739510.3389/fcimb.2023.1108348engFrontiers Media ASRosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil / Grupo de investigación en Química y Biotecnología. Facultad de Ciencias Básicas. Universidad Santiago de Cali. Cali, Colombia.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brazil / Universidade Federal do Amazonas. Departamento de Saúde Coletiva. Manaus, AM, Brazil / Universidade Nilton Lins. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, BrazilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil.Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil/ Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brazil.Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil/ Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brazil.Plasmodium vivax is a public health problem and the most common type of malaria outside sub-Saharan Africa. The capacity of cytoadhesion, rosetting, and liver latent phase development could impact treatment and disease control. Although the ability to P. vivax gametocyte develop rosetting is known, it is not yet clear which role it plays during the infection and transmission process to the mosquito. Here, we used ex vivo approaches for evaluate the rosetting P. vivax gametocytes capacity and we have investigated the effect of this adhesive phenotype on the infection process in the vector Anopheles aquasalis mosquito. Rosette assays were performed in 107 isolates, and we have observed an elevated frequency of cytoadhesive phenomena (77,6%). The isolates with more than 10% of rosettes have presented a higher infection rate in Anopheles aquasalis (p=0.0252). Moreover, we found a positive correlation between the frequency of parasites in rosetting with the infection rate (p=0.0017) and intensity (p=0.0387) in the mosquito. The disruption of P. vivax rosette formation through mechanical rupture assay confirmed the previously findings, since the paired comparison showed that isolates with disrupted rosettes have a lower infection rate (p<0.0001) and intensity (p=0.0003) compared to the control group (no disruption). Herein we have demonstrated for the first time a potential effect of the rosette phenomenon on the infection process in the mosquito vector An. aquasalis, favoring its capacity and intensity of infection, thus allowing the perpetuation of the parasite cycle life.malariagametocyterosettingcytoadhesionPlasmodium vivaxvectoranófelesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57395/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRosette formation by Plasmodium vivax gametocytes.pdfRosette formation by Plasmodium vivax gametocytes.pdfapplication/pdf1066844https://www.arca.fiocruz.br/bitstream/icict/57395/3/Rosette%20formation%20by%20Plasmodium%20vivax%20gametocytes.pdf7237a5fe8be7fbcd369273a667af57d6MD53icict/573952023-03-21 13:57:27.495oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-21T16:57:27Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
title Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
spellingShingle Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
Alvarez, Luis Carlos Salazar
malaria
gametocyte
rosetting
cytoadhesion
Plasmodium vivax
vector
anófeles
title_short Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
title_full Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
title_fullStr Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
title_full_unstemmed Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
title_sort Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis.
author Alvarez, Luis Carlos Salazar
author_facet Alvarez, Luis Carlos Salazar
Barbosa, Vanessa Carneiro
Lizcano, Omaira Vera
Silva, Djane Clarys Baia da
Santana, Rosa Amélia Gonçalves
Fabbri, Camila
Pimenta, Paulo Filemon Paoluci
Monteiro, Wuelton Marcelo
Albrecht, Letusa
Lacerda, Marcus Vinicius Guimarães de
Costa, Fabio Trindade Maranhão
Lopes, Stefanie Costa Pinto
author_role author
author2 Barbosa, Vanessa Carneiro
Lizcano, Omaira Vera
Silva, Djane Clarys Baia da
Santana, Rosa Amélia Gonçalves
Fabbri, Camila
Pimenta, Paulo Filemon Paoluci
Monteiro, Wuelton Marcelo
Albrecht, Letusa
Lacerda, Marcus Vinicius Guimarães de
Costa, Fabio Trindade Maranhão
Lopes, Stefanie Costa Pinto
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alvarez, Luis Carlos Salazar
Barbosa, Vanessa Carneiro
Lizcano, Omaira Vera
Silva, Djane Clarys Baia da
Santana, Rosa Amélia Gonçalves
Fabbri, Camila
Pimenta, Paulo Filemon Paoluci
Monteiro, Wuelton Marcelo
Albrecht, Letusa
Lacerda, Marcus Vinicius Guimarães de
Costa, Fabio Trindade Maranhão
Lopes, Stefanie Costa Pinto
dc.subject.en.en_US.fl_str_mv malaria
gametocyte
rosetting
cytoadhesion
Plasmodium vivax
vector
anófeles
topic malaria
gametocyte
rosetting
cytoadhesion
Plasmodium vivax
vector
anófeles
description Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Centro Internacional de Pesquisa Clínica em Malária. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brazil / Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-15T19:34:20Z
dc.date.available.fl_str_mv 2023-03-15T19:34:20Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALAZAR ALVAREZ, Luis Carlos et al. Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis. Frontiers in Cellular and Infection Microbiology, v. 13, 1108348, p. 1-7, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57395
dc.identifier.issn.en_US.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2023.1108348
identifier_str_mv SALAZAR ALVAREZ, Luis Carlos et al. Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis. Frontiers in Cellular and Infection Microbiology, v. 13, 1108348, p. 1-7, 2023.
2235-2988
10.3389/fcimb.2023.1108348
url https://www.arca.fiocruz.br/handle/icict/57395
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media AS
publisher.none.fl_str_mv Frontiers Media AS
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57395/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57395/3/Rosette%20formation%20by%20Plasmodium%20vivax%20gametocytes.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
7237a5fe8be7fbcd369273a667af57d6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324910246854656

Registros relacionados