Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial

Detalhes bibliográficos
Autor(a) principal: Yeganeh, Nava
Data de Publicação: 2018
Outros Autores: Watts, D. Heather, Xu, Jiahong, Kerin, Tara, Joao, Esau C., Pilotto, Jose Henrique, Theron, Gerhard, Gray, Glenda, Santos, Breno, Fonseca, Rosana, Kreitchmann, Regis, Pinto, Jorge, Mussi-Pinhata, Marisa M., Veloso, Valdiléa G., Camarca, Margaret, Mofenson, Lynne, Moye, Jack, Nielsen-Saines, Karin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33773
Resumo: 2020-07-02
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spelling Yeganeh, NavaWatts, D. HeatherXu, JiahongKerin, TaraJoao, Esau C.Pilotto, Jose HenriqueTheron, GerhardGray, GlendaSantos, BrenoFonseca, RosanaKreitchmann, RegisPinto, JorgeMussi-Pinhata, Marisa M.Veloso, Valdiléa G.Camarca, MargaretMofenson, LynneMoye, JackNielsen-Saines, Karin2019-07-02T14:11:35Z2019-07-02T14:11:35Z2018YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, v. 37, n. 12, p. 1271-1278, Dec. 2018.0891-3668https://www.arca.fiocruz.br/handle/icict/3377310.1097/INF.00000000000020821532-0987engLippincott, Williams & Wilkinshttps://www.arca.fiocruz.br/handle/icict/29114Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-02University of California, Los Angeles. David Geffen School of Medicine. Los Angeles, CA, USA.US Department of State. Office of the Global AIDS Coordinator and Health Diplomacy. Washington, DC, USA.Westat. Rockville, MD, USA.University of California, Los Angeles. David Geffen School of Medicine. Los Angeles, CA, USA.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Stellenbosch University. Perinatal HIV Research Unit. Cape Town, South Africa / Tygerberg Hospital. Cape Town, South Africa.University of Witwatersrand. Johannesburg, South Africa / Chris Hani Baragwanath Hospital, Johannesburg, South Africa.Hospital Conceição. Porto Alegre, RS, Brasil.Hospital Femina. Porto Alegre, RS, Brasil.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil.Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Universidade de São Paulo. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Westat. Rockville, MD, USA.Elisabeth Glaser Pediatric AIDS Foundation. Washington, DC, USA.National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA.University of California, Los Angeles. David Geffen School of Medicine. Los Angeles, CA, USA.Background: HIV-exposed uninfected (HEU) infants are a growing population with potentially poor health outcomes. We evaluated morbidity and mortality in HEU formula-fed infants enrolled in the NICHD HPTN 040/PACTG 1043 trial. Methods: Infectious morbidity, mortality and undernutrition were evaluated within a cohort of 1000 HEU infants enrolled between April 2004 and April 2010 in Brazil (n = 766) and South Africa (n = 234) as part of the NICHD/HPTN 040 trial of 3 different antiretroviral regimens to decrease intrapartum HIV vertical transmission. Results: Twenty-three percent of infants had at least 1 infectious serious adverse effect. Infants born to mothers with <12 years of education [adjusted odds ratio (AOR), 2.6; 95% confidence interval [CI], 1.2-5.9), with maternal viral load of >1,000,000 copies/mL at delivery (AOR, 9.9; 95% CI, 1.6-63.1) were more likely to have infectious serious adverse effects. At 6 months, the infant mortality rate per 1000 live births overall was 22 ± 2.6, 9.1 ± 1.8 in Brazil and 64.1 ± 3 in South Africa. Undernutrition and stunting peaked at 1 month of age with 18% having a weight-for-age Z score ≤-2, and 22% with height for Z score ≤-2. The likelihood of infant mortality was greater among infants born in South Africa compared with Brazil (AOR, 6.2; 95% CI, 2.5-15.8), high maternal viral load (AOR, 1.7; 95% CI, 1.01-2.9) and birth weight-for-age Z score ≤-2 (AOR, 5.2; 95% CI, 1.8-14.8). Conclusions: There were high rates of undernutrition, stunting and infectious serious adverse effect in this study's formula-fed HEU population. Suppressing maternal HIV viral load during the peripartum period may be a modifiable risk factor to decrease infant mortality.HIV exposedUninfected infantsFormula feedingUndernutritioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33773/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Yeganeh_Nava_etal_INI_2018.pdfve_Yeganeh_Nava_etal_INI_2018.pdfapplication/pdf337615https://www.arca.fiocruz.br/bitstream/icict/33773/2/ve_Yeganeh_Nava_etal_INI_2018.pdf24955656b80a4879abd09917c0ad8f41MD52TEXTve_Yeganeh_Nava_etal_INI_2018.pdf.txtve_Yeganeh_Nava_etal_INI_2018.pdf.txtExtracted texttext/plain49303https://www.arca.fiocruz.br/bitstream/icict/33773/3/ve_Yeganeh_Nava_etal_INI_2018.pdf.txt59f8b67d56d6d76a96d81d864fd90a86MD53icict/337732023-03-29 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dc.title.pt_BR.fl_str_mv Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
title Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
spellingShingle Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
Yeganeh, Nava
HIV exposed
Uninfected infants
Formula feeding
Undernutrition
title_short Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
title_full Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
title_fullStr Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
title_full_unstemmed Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
title_sort Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
author Yeganeh, Nava
author_facet Yeganeh, Nava
Watts, D. Heather
Xu, Jiahong
Kerin, Tara
Joao, Esau C.
Pilotto, Jose Henrique
Theron, Gerhard
Gray, Glenda
Santos, Breno
Fonseca, Rosana
Kreitchmann, Regis
Pinto, Jorge
Mussi-Pinhata, Marisa M.
Veloso, Valdiléa G.
Camarca, Margaret
Mofenson, Lynne
Moye, Jack
Nielsen-Saines, Karin
author_role author
author2 Watts, D. Heather
Xu, Jiahong
Kerin, Tara
Joao, Esau C.
Pilotto, Jose Henrique
Theron, Gerhard
Gray, Glenda
Santos, Breno
Fonseca, Rosana
Kreitchmann, Regis
Pinto, Jorge
Mussi-Pinhata, Marisa M.
Veloso, Valdiléa G.
Camarca, Margaret
Mofenson, Lynne
Moye, Jack
Nielsen-Saines, Karin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yeganeh, Nava
Watts, D. Heather
Xu, Jiahong
Kerin, Tara
Joao, Esau C.
Pilotto, Jose Henrique
Theron, Gerhard
Gray, Glenda
Santos, Breno
Fonseca, Rosana
Kreitchmann, Regis
Pinto, Jorge
Mussi-Pinhata, Marisa M.
Veloso, Valdiléa G.
Camarca, Margaret
Mofenson, Lynne
Moye, Jack
Nielsen-Saines, Karin
dc.subject.en.pt_BR.fl_str_mv HIV exposed
Uninfected infants
Formula feeding
Undernutrition
topic HIV exposed
Uninfected infants
Formula feeding
Undernutrition
description 2020-07-02
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-07-02T14:11:35Z
dc.date.available.fl_str_mv 2019-07-02T14:11:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, v. 37, n. 12, p. 1271-1278, Dec. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33773
dc.identifier.issn.pt_BR.fl_str_mv 0891-3668
dc.identifier.doi.none.fl_str_mv 10.1097/INF.0000000000002082
dc.identifier.eissn.none.fl_str_mv 1532-0987
identifier_str_mv YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, v. 37, n. 12, p. 1271-1278, Dec. 2018.
0891-3668
10.1097/INF.0000000000002082
1532-0987
url https://www.arca.fiocruz.br/handle/icict/33773
dc.language.iso.fl_str_mv eng
language eng
dc.relation.isversionof.none.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29114
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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