Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29114 |
Resumo: | 2020-05-31 |
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Yeganeh, NavaWatts, D HeatherXu, JiahongKerin, TaraJoao, Esau C.Pilotto, Jose HenriqueTheron, GerhardGray, GlendaSantos, BrenoFonseca, RosanaKreitchmann, RegisPinto, JorgeMussi-Pinhata, Marisa M.Veloso, Valdiléa G.Camarca, MargaretMofenson, LynneMoye, JackNielsen-Saines, Karin2018-09-27T16:29:52Z2018-09-27T16:29:52Z2018YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, p. 1-31, 2018.0891-3668https://www.arca.fiocruz.br/handle/icict/2911410.1097/INF.0000000000002082engWilliams & Wilkinshttps://www.arca.fiocruz.br/handle/icict/33773Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-05-31David Geffen UCLA School of Medicine. Los Angeles, USA.Office of the Global AIDS Coordinator and Health Diplomacy. U.S. Dept. of State, Washington, USA.Westat. Rockville, USA.David Geffen UCLA School of Medicine. Los Angeles, USA.Hospital Federal dos Servidores do Estado. Rio de Janeiro, Brasil.Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Perinatal HIV Research Unit. Rio de Janeiro, RJ, Brasil.Stellenbosch University. Tygerberg Hospital, Cape Town, South Africa.University of Witwatersrand. Chris Hani Baragwanath Hospital. Johannesburg, South Africa.Hospital Conceição. Porto Alegre, RS, Brasil.Hospital Femina. Porto Alegre, RS, Brasil.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Universidade de São Paulo, Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Elisabeth Glaser Pediatric AIDS Foundation. Washington DC.Eunice Kennedy Shriver National Institute of Child Health and Human Development. National Institutes of Health. Bethesda, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.Background: HIV-exposed uninfected (HEU) infants are a growing population with potentially poor health outcomes. We evaluated morbidity and mortality in HEU formula-fed infants enrolled in the NICHD HPTN 040/PACTG 1043 trial. Methods: Infectious morbidity, mortality and undernutrition were evaluated within a cohort of 1000 HEU infants enrolled between April 2004 and April 2010 in Brazil (n = 766) and South Africa (n = 234) as part of the NICHD/HPTN 040 trial of 3 different antiretroviral regimens to decrease intrapartum HIV vertical transmission. Results: Twenty-three percent of infants had at least 1 infectious serious adverse effect. Infants born to mothers with <12 years of education [adjusted odds ratio (AOR), 2.6; 95% confidence interval [CI], 1.2-5.9), with maternal viral load of >1,000,000 copies/mL at delivery (AOR, 9.9; 95% CI, 1.6-63.1) were more likely to have infectious serious adverse effects. At 6 months, the infant mortality rate per 1000 live births overall was 22 ± 2.6, 9.1 ± 1.8 in Brazil and 64.1 ± 3 in South Africa. Undernutrition and stunting peaked at 1 month of age with 18% having a weight-for-age Z score ≤-2, and 22% with height for Z score ≤-2. The likelihood of infant mortality was greater among infants born in South Africa compared with Brazil (AOR, 6.2; 95% CI, 2.5-15.8), high maternal viral load (AOR, 1.7; 95% CI, 1.01-2.9) and birth weight-for-age Z score ≤-2 (AOR, 5.2; 95% CI, 1.8-14.8). Conclusions: There were high rates of undernutrition, stunting and infectious serious adverse effect in this study's formula-fed HEU population. Suppressing maternal HIV viral load during the peripartum period may be a modifiable risk factor to decrease infant mortality.Uninfected infantsFormula feedingUndernutritionHIVHPTN 040HIV exposedNãoNão publicadoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/29114/1/license.txt73c2438d9038594f05d706f987b602c3MD51ORIGINALInfectious Morbidity, Mortality and Nutrition in HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdfInfectious Morbidity, Mortality and Nutrition in HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdfapplication/pdf2056143https://www.arca.fiocruz.br/bitstream/icict/29114/2/Infectious%20Morbidity%2c%20Mortality%20and%20Nutrition%20in%20HIV_Valdilea_Veloso_INI_Lapclin-AIDS_2018.pdf6fdeb93e752d7dd13ef285d00cd327d1MD52TEXTInfectious Morbidity, Mortality and Nutrition in 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dc.title.pt_BR.fl_str_mv |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
title |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
spellingShingle |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial Yeganeh, Nava Uninfected infants Formula feeding Undernutrition HIV HPTN 040 HIV exposed |
title_short |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
title_full |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
title_fullStr |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
title_full_unstemmed |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
title_sort |
Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial |
author |
Yeganeh, Nava |
author_facet |
Yeganeh, Nava Watts, D Heather Xu, Jiahong Kerin, Tara Joao, Esau C. Pilotto, Jose Henrique Theron, Gerhard Gray, Glenda Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa M. Veloso, Valdiléa G. Camarca, Margaret Mofenson, Lynne Moye, Jack Nielsen-Saines, Karin |
author_role |
author |
author2 |
Watts, D Heather Xu, Jiahong Kerin, Tara Joao, Esau C. Pilotto, Jose Henrique Theron, Gerhard Gray, Glenda Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa M. Veloso, Valdiléa G. Camarca, Margaret Mofenson, Lynne Moye, Jack Nielsen-Saines, Karin |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Yeganeh, Nava Watts, D Heather Xu, Jiahong Kerin, Tara Joao, Esau C. Pilotto, Jose Henrique Theron, Gerhard Gray, Glenda Santos, Breno Fonseca, Rosana Kreitchmann, Regis Pinto, Jorge Mussi-Pinhata, Marisa M. Veloso, Valdiléa G. Camarca, Margaret Mofenson, Lynne Moye, Jack Nielsen-Saines, Karin |
dc.subject.en.pt_BR.fl_str_mv |
Uninfected infants Formula feeding Undernutrition HIV HPTN 040 HIV exposed |
topic |
Uninfected infants Formula feeding Undernutrition HIV HPTN 040 HIV exposed |
description |
2020-05-31 |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-09-27T16:29:52Z |
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2018-09-27T16:29:52Z |
dc.date.issued.fl_str_mv |
2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, p. 1-31, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/29114 |
dc.identifier.issn.none.fl_str_mv |
0891-3668 |
dc.identifier.doi.none.fl_str_mv |
10.1097/INF.0000000000002082 |
identifier_str_mv |
YEGANEH, Nava et al. Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial. The Pediatric Infectious Disease Journal, p. 1-31, 2018. 0891-3668 10.1097/INF.0000000000002082 |
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https://www.arca.fiocruz.br/handle/icict/29114 |
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eng |
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eng |
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Williams & Wilkins |
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Williams & Wilkins |
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