Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide

Detalhes bibliográficos
Autor(a) principal: Braga, B.V.
Data de Publicação: 2021
Outros Autores: Garcia, J. S., Simões, R. O, Silva, J. S. P., Castro, L. S., Silva, C. H., Maldonado Jr., A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50098
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.
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spelling Braga, B.V.Garcia, J. S.Simões, R. OSilva, J. S. P.Castro, L. S.Silva, C. H.Maldonado Jr., A.2021-11-29T20:17:02Z2021-11-29T20:17:02Z2021BRAGA, B. V. et al. Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide. Annals of Agricultural & Crop Sciences, v. 6, n. 6, p. 1-6, 2021.2573-3583https://www.arca.fiocruz.br/handle/icict/50098Não encontradoengAustin Publishing GroupParâmetros hepáticos bioquímicosInfecção ExperimentalHelmintoRoundup®Biochemical hepatic parametersExperimental InfectionHelminthRoundup®Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicideinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Departamento de Parasitologia Animal. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Biológicas e da Saúde. Departamento de Ciências Fisiológicas. Laboratório de Fisiologia das Relações Parasitárias. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Biológicas e da Saúde. Departamento de Ciências Fisiológicas. Laboratório de Fisiologia das Relações Parasitárias. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.Helminth infection associated with exposure to pesticides has received little attention regarding its effect on the human population and on farm and wild animals. The aim of this study was to evaluate the effects a glyphosate-based herbicide on the hepatic and glycemic metabolism of Rattus norvegicus (Wistar) infected by Angiostrongylus cantonensis. Experimental groups were orally infected with 50 L3 larvae of A. cantonensis and exposed to the herbicide after and before the infection. Biochemical serum analyses were carried out to determine the levels of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total Bilirubin (TB), total protein, albumin, urea, creatinine, uric acid, glucose and hepatic glycogen. All exposed groups showed an increase in the concentration of glycogen, AST, ALT and TB, the last ones suggesting liver tissue damage. Exposure to the herbicide caused hyperalbuminemia as an antioxidant response to the herbicide. These findings contribute to a better understanding of how glyphosate-based herbicides can change the hepatic metabolism the vertebrate and to influence the parasite-host relationship.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50098/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBVBraga_AMaldonadoJr_etal_IOC_2021.pdfBVBraga_AMaldonadoJr_etal_IOC_2021.pdfapplication/pdf3010226https://www.arca.fiocruz.br/bitstream/icict/50098/2/BVBraga_AMaldonadoJr_etal_IOC_2021.pdf309e6601d5e40eabef7f0174b79a004aMD52icict/500982022-06-24 12:59:52.342oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:59:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
title Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
spellingShingle Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
Braga, B.V.
Parâmetros hepáticos bioquímicos
Infecção Experimental
Helminto
Roundup®
Biochemical hepatic parameters
Experimental Infection
Helminth
Roundup®
title_short Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
title_full Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
title_fullStr Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
title_full_unstemmed Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
title_sort Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide
author Braga, B.V.
author_facet Braga, B.V.
Garcia, J. S.
Simões, R. O
Silva, J. S. P.
Castro, L. S.
Silva, C. H.
Maldonado Jr., A.
author_role author
author2 Garcia, J. S.
Simões, R. O
Silva, J. S. P.
Castro, L. S.
Silva, C. H.
Maldonado Jr., A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Braga, B.V.
Garcia, J. S.
Simões, R. O
Silva, J. S. P.
Castro, L. S.
Silva, C. H.
Maldonado Jr., A.
dc.subject.other.pt_BR.fl_str_mv Parâmetros hepáticos bioquímicos
Infecção Experimental
Helminto
Roundup®
topic Parâmetros hepáticos bioquímicos
Infecção Experimental
Helminto
Roundup®
Biochemical hepatic parameters
Experimental Infection
Helminth
Roundup®
dc.subject.en.pt_BR.fl_str_mv Biochemical hepatic parameters
Experimental Infection
Helminth
Roundup®
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-29T20:17:02Z
dc.date.available.fl_str_mv 2021-11-29T20:17:02Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRAGA, B. V. et al. Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide. Annals of Agricultural & Crop Sciences, v. 6, n. 6, p. 1-6, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50098
dc.identifier.issn.pt_BR.fl_str_mv 2573-3583
dc.identifier.eissn.none.fl_str_mv Não encontrado
identifier_str_mv BRAGA, B. V. et al. Changes in Hepatic Metabolism of Rattus norvegicus Infected to Angiostrongylus cantonensis (Nematoda) and Exposed to Glyphosate-Based Herbicide. Annals of Agricultural & Crop Sciences, v. 6, n. 6, p. 1-6, 2021.
2573-3583
Não encontrado
url https://www.arca.fiocruz.br/handle/icict/50098
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Austin Publishing Group
publisher.none.fl_str_mv Austin Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50098/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50098/2/BVBraga_AMaldonadoJr_etal_IOC_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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