New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17846 |
Resumo: | 2020-06-30 |
id |
CRUZ_346bba0651fffddc9479487e1fb06732 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/17846 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Aslan, HamideOliveira, FabianoMeneses, ClaudioCastrovinci, PhilipGomes, RegisTeixeira, ClarissaDerenge, Candace A.Orandle, MarleneGradoni, LuigiOliva, GaetanoFischer, LaurentValenzuela, Jesus G.Kamhawi, Shaden2017-02-16T17:34:04Z2017-02-16T17:34:04Z2016ASLAN, Hamide et al. New insights into the transmissibility of Leishmania infantum from dogs to sand flies: experimental transmission reveals persistent parasite depots at bite sites. The Journal of Infectious Diseases, p.1752-1761, 1 June, 2016.1537-6613https://www.arca.fiocruz.br/handle/icict/17846porMartin S. HirschLeishmaniose caninaLeishmania infantumLutzomyia longipalpisReservatórioTransmissão vetorialInfectividadeCanine leishmaniasisLeishmania infantumLutzomyia longipalpisReservoirVector transmissionInfectivityNew insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-30Faculty of Health Science. Selahaddin Eyyubi University. Diyarbakir, Turkey/ Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA / Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA / Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Comparative Medicine Branch. National Institute of Allergy and Infectious Diseases. National Institutes of Health,Rockville, Maryland, USA.Unit of Vector-Borne Diseases and International Health. Istituto Superiore di Sanità. Rome. Italy.Department of Veterinary Medicine and Animal Productions. University Federico II. Naples, Italy.Merial S.A.S., R&D. Laboratoire de Lyon Gerland. Paris, France.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.Canine leishmaniasis (CanL) is a chronic fatal disease of dogs and a major source of human infection through propagation of parasites in vectors. Here, we infected 8 beagles through multiple experimental vector transmissions with Leishmania infantum–infected Lutzomyia longipalpis. CanL clinical signs varied, although live parasites were recovered from all dog spleens. Splenic parasite burdens correlated positively with Leishmania-specific interleukin 10 levels, negatively with Leishmania specific interferon γ and interleukin 2 levels, and negatively with Leishmania skin test reactivity. A key finding was parasite persistence for 6 months in lesions observed at the bite sites in all dogs. These recrudesced following a second transmission performed at a distal site. Notably, sand flies efficiently acquired parasites after feeding on lesions at the primary bite site. In this study, controlled vector transmissions identify a potentially unappreciated role for skin at infectious bite sites in dogs with CanL, providing a new perspective regarding the mechanism of Leishmania transmissibility to vector sand flies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Hamide_Aslan_et_al_2016.pdfve_Hamide_Aslan_et_al_2016.pdfapplication/pdf778106https://www.arca.fiocruz.br/bitstream/icict/17846/2/ve_Hamide_Aslan_et_al_2016.pdf405fd5193c596517e5444769093db363MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17846/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTve_Hamide_Aslan_et_al_2016.pdf.txtve_Hamide_Aslan_et_al_2016.pdf.txtExtracted texttext/plain44715https://www.arca.fiocruz.br/bitstream/icict/17846/4/ve_Hamide_Aslan_et_al_2016.pdf.txt7528f4ebbf9f0c720ade873a842f0aacMD54icict/178462021-03-24 16:32:33.811oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
title |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
spellingShingle |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites Aslan, Hamide Leishmaniose canina Leishmania infantum Lutzomyia longipalpis Reservatório Transmissão vetorial Infectividade Canine leishmaniasis Leishmania infantum Lutzomyia longipalpis Reservoir Vector transmission Infectivity |
title_short |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
title_full |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
title_fullStr |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
title_full_unstemmed |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
title_sort |
New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites |
author |
Aslan, Hamide |
author_facet |
Aslan, Hamide Oliveira, Fabiano Meneses, Claudio Castrovinci, Philip Gomes, Regis Teixeira, Clarissa Derenge, Candace A. Orandle, Marlene Gradoni, Luigi Oliva, Gaetano Fischer, Laurent Valenzuela, Jesus G. Kamhawi, Shaden |
author_role |
author |
author2 |
Oliveira, Fabiano Meneses, Claudio Castrovinci, Philip Gomes, Regis Teixeira, Clarissa Derenge, Candace A. Orandle, Marlene Gradoni, Luigi Oliva, Gaetano Fischer, Laurent Valenzuela, Jesus G. Kamhawi, Shaden |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Aslan, Hamide Oliveira, Fabiano Meneses, Claudio Castrovinci, Philip Gomes, Regis Teixeira, Clarissa Derenge, Candace A. Orandle, Marlene Gradoni, Luigi Oliva, Gaetano Fischer, Laurent Valenzuela, Jesus G. Kamhawi, Shaden |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose canina Leishmania infantum Lutzomyia longipalpis Reservatório Transmissão vetorial Infectividade |
topic |
Leishmaniose canina Leishmania infantum Lutzomyia longipalpis Reservatório Transmissão vetorial Infectividade Canine leishmaniasis Leishmania infantum Lutzomyia longipalpis Reservoir Vector transmission Infectivity |
dc.subject.en.pt_BR.fl_str_mv |
Canine leishmaniasis Leishmania infantum Lutzomyia longipalpis Reservoir Vector transmission Infectivity |
description |
2020-06-30 |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-16T17:34:04Z |
dc.date.available.fl_str_mv |
2017-02-16T17:34:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ASLAN, Hamide et al. New insights into the transmissibility of Leishmania infantum from dogs to sand flies: experimental transmission reveals persistent parasite depots at bite sites. The Journal of Infectious Diseases, p.1752-1761, 1 June, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17846 |
dc.identifier.issn.pt_BR.fl_str_mv |
1537-6613 |
identifier_str_mv |
ASLAN, Hamide et al. New insights into the transmissibility of Leishmania infantum from dogs to sand flies: experimental transmission reveals persistent parasite depots at bite sites. The Journal of Infectious Diseases, p.1752-1761, 1 June, 2016. 1537-6613 |
url |
https://www.arca.fiocruz.br/handle/icict/17846 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Martin S. Hirsch |
publisher.none.fl_str_mv |
Martin S. Hirsch |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/17846/2/ve_Hamide_Aslan_et_al_2016.pdf https://www.arca.fiocruz.br/bitstream/icict/17846/3/license.txt https://www.arca.fiocruz.br/bitstream/icict/17846/4/ve_Hamide_Aslan_et_al_2016.pdf.txt |
bitstream.checksum.fl_str_mv |
405fd5193c596517e5444769093db363 5a560609d32a3863062d77ff32785d58 7528f4ebbf9f0c720ade873a842f0aac |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1798324848557031424 |