In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Detalhes bibliográficos
Autor(a) principal: Caneschi, César Augusto
Data de Publicação: 2017
Outros Autores: Almeida, Angelina Maria de, Martins, Francislene Juliana, Le Hyaric, Mireille, Oliveira, Manoel Marques Evangelista, Macedo, Gilson Costa, Almeida, Mauro Vieira de, Raposo, Nádia Rezende Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31288
Resumo: Universidade Federal de Juiz de Fora. Faculdade de Farmácia. Núcleo de Pesquisa e Inovação em Ciências da Saúde. Juiz de Fora, MG, Brasil.
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spelling Caneschi, César AugustoAlmeida, Angelina Maria deMartins, Francislene JulianaLe Hyaric, MireilleOliveira, Manoel Marques EvangelistaMacedo, Gilson CostaAlmeida, Mauro Vieira deRaposo, Nádia Rezende Barbosa2019-01-24T13:25:34Z2019-01-24T13:25:34Z2017CANESCHI, César Augusto et al. In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis. Brazilian Journal of Microbiology, v. 48, p. 476-482, 2017.1517-8382https://www.arca.fiocruz.br/handle/icict/3128810.1016/j.bjm.2016.12.0081678-4405engSociedade Brasileira de MicrobiologiaIn vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Juiz de Fora. Faculdade de Farmácia. Núcleo de Pesquisa e Inovação em Ciências da Saúde. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Faculdade de Farmácia. Núcleo de Pesquisa e Inovação em Ciências da Saúde. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Faculdade de Farmácia. Núcleo de Pesquisa e Inovação em Ciências da Saúde. Juiz de Fora, MG, Brasil.Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a-4f) and p-hydroxybenzoic acid (9a-9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series 4b-4e, mainly 4c and 4e compounds, were effective against filamentous fungi and yeast (MIC from 7.8 to 312μg/mL). On the other hand, the amide series (9a-9f) did not present inhibitory effect against fungi, except amide 9c, which demonstrated activity only against C. albicans. This allowed us to infer that the presence of amine group and intermediate carbon number (8C-11C) in its aliphatic side chain seems to be important for antifungal activity. Although these compounds present cytotoxic activity on macrophages J774, our results suggest that these aromatic compounds might constitute potential as leader molecules in the development of more effective and less toxic analogs that could have considerable implications for future therapies of onychomycosis.Amino alcoholsAmidesLipophilicityAntifungal activityOnychomycosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31288/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Caneschi_César_etal_INI_2017.pdfve_Caneschi_César_etal_INI_2017.pdfapplication/pdf1157714https://www.arca.fiocruz.br/bitstream/icict/31288/2/ve_Caneschi_C%c3%a9sar_etal_INI_2017.pdf4362160fea4bf05c672a757316bc6876MD52TEXTve_Caneschi_César_etal_INI_2017.pdf.txtve_Caneschi_César_etal_INI_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
title In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
spellingShingle In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
Caneschi, César Augusto
Amino alcohols
Amides
Lipophilicity
Antifungal activity
Onychomycosis
title_short In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
title_full In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
title_fullStr In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
title_full_unstemmed In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
title_sort In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
author Caneschi, César Augusto
author_facet Caneschi, César Augusto
Almeida, Angelina Maria de
Martins, Francislene Juliana
Le Hyaric, Mireille
Oliveira, Manoel Marques Evangelista
Macedo, Gilson Costa
Almeida, Mauro Vieira de
Raposo, Nádia Rezende Barbosa
author_role author
author2 Almeida, Angelina Maria de
Martins, Francislene Juliana
Le Hyaric, Mireille
Oliveira, Manoel Marques Evangelista
Macedo, Gilson Costa
Almeida, Mauro Vieira de
Raposo, Nádia Rezende Barbosa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caneschi, César Augusto
Almeida, Angelina Maria de
Martins, Francislene Juliana
Le Hyaric, Mireille
Oliveira, Manoel Marques Evangelista
Macedo, Gilson Costa
Almeida, Mauro Vieira de
Raposo, Nádia Rezende Barbosa
dc.subject.en.pt_BR.fl_str_mv Amino alcohols
Amides
Lipophilicity
Antifungal activity
Onychomycosis
topic Amino alcohols
Amides
Lipophilicity
Antifungal activity
Onychomycosis
description Universidade Federal de Juiz de Fora. Faculdade de Farmácia. Núcleo de Pesquisa e Inovação em Ciências da Saúde. Juiz de Fora, MG, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-01-24T13:25:34Z
dc.date.available.fl_str_mv 2019-01-24T13:25:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CANESCHI, César Augusto et al. In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis. Brazilian Journal of Microbiology, v. 48, p. 476-482, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31288
dc.identifier.issn.pt_BR.fl_str_mv 1517-8382
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjm.2016.12.008
dc.identifier.eissn.none.fl_str_mv 1678-4405
identifier_str_mv CANESCHI, César Augusto et al. In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis. Brazilian Journal of Microbiology, v. 48, p. 476-482, 2017.
1517-8382
10.1016/j.bjm.2016.12.008
1678-4405
url https://www.arca.fiocruz.br/handle/icict/31288
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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