Preparation and antitubercular activity of lipophilic diamines and amino alcohols

Detalhes bibliográficos
Autor(a) principal: R. Júnior, Celso O.
Data de Publicação: 2009
Outros Autores: Le Hyaric, Mireille, Costa, Cristiane F. da, Corrêa, Taís A., Taveira, Aline F., Araújo, Débora P., Reis, Elaine F. C., Lourenço, Maria Cristina S., Vicente, Felipe R. C., Almeida, Mauro V. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39013
Resumo: A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
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spelling R. Júnior, Celso O.Le Hyaric, MireilleCosta, Cristiane F. daCorrêa, Taís A.Taveira, Aline F.Araújo, Débora P.Reis, Elaine F. C.Lourenço, Maria Cristina S.Vicente, Felipe R. C.Almeida, Mauro V. de2020-01-07T12:18:49Z2020-01-07T12:18:49Z2009R. JÚNIOR, Celso O. et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 5, p. 703-705, Aug. 2009.0074-0276https://www.arca.fiocruz.br/handle/icict/3901310.1590/S0074-027620090005000061678-8060A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.engInstituto Oswaldo Cruz, Ministério da SaúdePreparation and antitubercular activity of lipophilic diamines and amino alcoholsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTuberculosisAmino alcoholsDiaminesLipophilicityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/39013/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_R_Júnior_Celso_etal_INI_2009.pdfve_R_Júnior_Celso_etal_INI_2009.pdfapplication/pdf286895https://www.arca.fiocruz.br/bitstream/icict/39013/2/ve_R_J%c3%banior_Celso_etal_INI_2009.pdfdb1ef01da530ff4a04f2d4662deba55eMD52TEXTve_R_Júnior_Celso_etal_INI_2009.pdf.txtve_R_Júnior_Celso_etal_INI_2009.pdf.txtExtracted texttext/plain9821https://www.arca.fiocruz.br/bitstream/icict/39013/3/ve_R_J%c3%banior_Celso_etal_INI_2009.pdf.txte8b485656353d3af623e3b2a92d226dcMD53icict/390132021-04-27 15:03:31.667oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-04-27T18:03:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en.fl_str_mv Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title Preparation and antitubercular activity of lipophilic diamines and amino alcohols
spellingShingle Preparation and antitubercular activity of lipophilic diamines and amino alcohols
R. Júnior, Celso O.
Tuberculosis
Amino alcohols
Diamines
Lipophilicity
title_short Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_full Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_fullStr Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_full_unstemmed Preparation and antitubercular activity of lipophilic diamines and amino alcohols
title_sort Preparation and antitubercular activity of lipophilic diamines and amino alcohols
author R. Júnior, Celso O.
author_facet R. Júnior, Celso O.
Le Hyaric, Mireille
Costa, Cristiane F. da
Corrêa, Taís A.
Taveira, Aline F.
Araújo, Débora P.
Reis, Elaine F. C.
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Almeida, Mauro V. de
author_role author
author2 Le Hyaric, Mireille
Costa, Cristiane F. da
Corrêa, Taís A.
Taveira, Aline F.
Araújo, Débora P.
Reis, Elaine F. C.
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Almeida, Mauro V. de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv R. Júnior, Celso O.
Le Hyaric, Mireille
Costa, Cristiane F. da
Corrêa, Taís A.
Taveira, Aline F.
Araújo, Débora P.
Reis, Elaine F. C.
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Almeida, Mauro V. de
dc.subject.en.en.fl_str_mv Tuberculosis
Amino alcohols
Diamines
Lipophilicity
topic Tuberculosis
Amino alcohols
Diamines
Lipophilicity
description A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-07T12:18:49Z
dc.date.available.fl_str_mv 2020-01-07T12:18:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv R. JÚNIOR, Celso O. et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 5, p. 703-705, Aug. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39013
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762009000500006
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv R. JÚNIOR, Celso O. et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 5, p. 703-705, Aug. 2009.
0074-0276
10.1590/S0074-02762009000500006
1678-8060
url https://www.arca.fiocruz.br/handle/icict/39013
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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