Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37574 |
Resumo: | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. |
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Burth, PatriciaYounes-Ibrahim, MauricioSantos, Maria C. B.Faria Neto, Hugo Caire C.Faria, Mauro Velho de Castro2019-12-04T14:56:21Z2019-12-04T14:56:21Z2005BURTH, Patricia et al. Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection. The Journal of Infectious Diseases, v. 191, p. 51-57, 2005.1904-2013https://www.arca.fiocruz.br/handle/icict/3757410.1086/426455engInfectious Diseases Society of America.LeptospiroseÁcidos graxos não saturadosProcessos fisiopatológicosInfecção leptospiralNonesterified Unsaturated Fatty AcidsPathophysiological ProcessesLeptospiral InfectionLeptospirosisRole of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Organ malfunctions in patients with leptospirosis have been associated with the bacterial glycolipoprotein endotoxin and with its nonesterified unsaturated fatty acid (NEUFA) components. We examined the involvement of NEUFAs in the pathophysiological processes of leptospirosis. Patients showed a moderate increase in serum concentrations of oleic and linoleic acids but an important decrease in serum concentrations of albumin. A highly significant correlation between serum concentrations of creatinine or total bilirubin and the oleic-plus-linoleic acid : albumin ratio was revealed. We used the Na(+),K(+)-ATPase inhibitory property of NEUFAs to test the capacity of serum to prevent the cytotoxic effects of NEUFAs in vitro. Albumin solutions and serum samples from healthy volunteers, but not serum samples from severely affected patients, were able to revert the Na(+),K(+)-ATPase inhibition by oleic acid. On the basis of these data, we defined a "serum protection factor" that can be helpful in predicting NEUFA toxicity. Our data support the concept that the administration of human albumin to patients may be helpful in severe leptospirosis cases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37574/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHugoCastro_FariaNeto_etal_IOC_2005.pdfHugoCastro_FariaNeto_etal_IOC_2005.pdfapplication/pdf549151https://www.arca.fiocruz.br/bitstream/icict/37574/2/HugoCastro_FariaNeto_etal_IOC_2005.pdfcbe4c7fd435fe851abcc1651bd9ed8b1MD52TEXTHugoCastro_FariaNeto_etal_IOC_2005.pdf.txtHugoCastro_FariaNeto_etal_IOC_2005.pdf.txtExtracted texttext/plain34742https://www.arca.fiocruz.br/bitstream/icict/37574/3/HugoCastro_FariaNeto_etal_IOC_2005.pdf.txt46c27287cb53972feca96de065d14af2MD53icict/375742019-12-05 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| dc.title.pt_BR.fl_str_mv |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| title |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| spellingShingle |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection Burth, Patricia Leptospirose Ácidos graxos não saturados Processos fisiopatológicos Infecção leptospiral Nonesterified Unsaturated Fatty Acids Pathophysiological Processes Leptospiral Infection Leptospirosis |
| title_short |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| title_full |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| title_fullStr |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| title_full_unstemmed |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| title_sort |
Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection |
| author |
Burth, Patricia |
| author_facet |
Burth, Patricia Younes-Ibrahim, Mauricio Santos, Maria C. B. Faria Neto, Hugo Caire C. Faria, Mauro Velho de Castro |
| author_role |
author |
| author2 |
Younes-Ibrahim, Mauricio Santos, Maria C. B. Faria Neto, Hugo Caire C. Faria, Mauro Velho de Castro |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Burth, Patricia Younes-Ibrahim, Mauricio Santos, Maria C. B. Faria Neto, Hugo Caire C. Faria, Mauro Velho de Castro |
| dc.subject.other.pt_BR.fl_str_mv |
Leptospirose Ácidos graxos não saturados Processos fisiopatológicos Infecção leptospiral |
| topic |
Leptospirose Ácidos graxos não saturados Processos fisiopatológicos Infecção leptospiral Nonesterified Unsaturated Fatty Acids Pathophysiological Processes Leptospiral Infection Leptospirosis |
| dc.subject.en.pt_BR.fl_str_mv |
Nonesterified Unsaturated Fatty Acids Pathophysiological Processes Leptospiral Infection Leptospirosis |
| description |
Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. |
| publishDate |
2005 |
| dc.date.issued.fl_str_mv |
2005 |
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2019-12-04T14:56:21Z |
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2019-12-04T14:56:21Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BURTH, Patricia et al. Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection. The Journal of Infectious Diseases, v. 191, p. 51-57, 2005. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/37574 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1904-2013 |
| dc.identifier.doi.none.fl_str_mv |
10.1086/426455 |
| identifier_str_mv |
BURTH, Patricia et al. Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection. The Journal of Infectious Diseases, v. 191, p. 51-57, 2005. 1904-2013 10.1086/426455 |
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https://www.arca.fiocruz.br/handle/icict/37574 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Infectious Diseases Society of America. |
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Infectious Diseases Society of America. |
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