Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis

Detalhes bibliográficos
Autor(a) principal: Sabatke, Bruna
Data de Publicação: 2022
Outros Autores: Chaves, Pedro Felipe P., Cordeiro, Lucimara M. C., Ramirez, Marcel Ivan
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57002
Resumo: Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. EVAHPI – Extracellular Vesicles and Host-Parasite Interactions Research Group. Curitiba, PR, Brasil.
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spelling Sabatke, BrunaChaves, Pedro Felipe P.Cordeiro, Lucimara M. C.Ramirez, Marcel Ivan2023-02-10T14:45:20Z2023-02-10T14:45:20Z2022SABATKE, Bruna et al. Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis. Life., v. 12, n. 2091, p. 1–9, 2022.2075-1729https://www.arca.fiocruz.br/handle/icict/5700210.3390/life12122091porMDPISynergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. EVAHPI – Extracellular Vesicles and Host-Parasite Interactions Research Group. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. EVAHPI – Extracellular Vesicles and Host-Parasite Interactions Research Group. Curitiba, PR, Brasil.Giardia intestinalis (syn. G. lamblia, G. duodenalis) is a protozoa parasite that produces one of the most frequent waterborne causes of diarrhea worldwide. This protozoan infects most mammals, including humans, and colonizes the small intestine, adhering to intestinal cells. The mechanism by which G. intestinalis causes diarrhea is multifactorial, causing intestinal malabsorption. The treatment of giardiasis uses chemotherapeutic drugs such as nitroimidazoles, furazolidone, paromomycin, and benzimidazole compounds. However, they are toxic, refractory, and may generate resistance. To increase efficacy, a current treatment strategy is to combine these drugs with other compounds, suchas polysaccharides. Several studies have shown that polysaccharides have gastroprotective effects. Polysaccharides are high-molecular weight polymers, and they differ in structure and functions, being widely extracted from vegetables and fruits. In the present study, we show that polysaccharides found in chamomile tea (called MRW), in contact with antiparasitic agents, potentially inhibit the adhesion of parasites to intestinal cells. Moreover, at 500 µg/mL, they act synergistically with nitazoxanide (NTZ), increasing its effectiveness and decreasing the drug dose needed for giardiasis treatment.ChamomilePolysaccharidesGiardia intestinalisAntiparasitic AgentsComplementary TherapiesSynergismManzanillaPolisacáridosGiardiasisAntiparasitariosTerapias ComplementariasCamomillePolyosidesAntiparasitairesThérapies complémentairesSynergieCamomilaPolissacarídeosGiardíaseAntiparasitáriosTerapias ComplementaresSinergismo de Substâncias Bioativasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
title Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
spellingShingle Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
Sabatke, Bruna
Chamomile
Polysaccharides
Giardia intestinalis
Antiparasitic Agents
Complementary Therapies
Synergism
Manzanilla
Polisacáridos
Giardiasis
Antiparasitarios
Terapias Complementarias
Camomille
Polyosides
Antiparasitaires
Thérapies complémentaires
Synergie
Camomila
Polissacarídeos
Giardíase
Antiparasitários
Terapias Complementares
Sinergismo de Substâncias Bioativas
title_short Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
title_full Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
title_fullStr Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
title_full_unstemmed Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
title_sort Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis
author Sabatke, Bruna
author_facet Sabatke, Bruna
Chaves, Pedro Felipe P.
Cordeiro, Lucimara M. C.
Ramirez, Marcel Ivan
author_role author
author2 Chaves, Pedro Felipe P.
Cordeiro, Lucimara M. C.
Ramirez, Marcel Ivan
author2_role author
author
author
dc.contributor.author.fl_str_mv Sabatke, Bruna
Chaves, Pedro Felipe P.
Cordeiro, Lucimara M. C.
Ramirez, Marcel Ivan
dc.subject.en.en_US.fl_str_mv Chamomile
Polysaccharides
Giardia intestinalis
Antiparasitic Agents
Complementary Therapies
Synergism
topic Chamomile
Polysaccharides
Giardia intestinalis
Antiparasitic Agents
Complementary Therapies
Synergism
Manzanilla
Polisacáridos
Giardiasis
Antiparasitarios
Terapias Complementarias
Camomille
Polyosides
Antiparasitaires
Thérapies complémentaires
Synergie
Camomila
Polissacarídeos
Giardíase
Antiparasitários
Terapias Complementares
Sinergismo de Substâncias Bioativas
dc.subject.es.en_US.fl_str_mv Manzanilla
Polisacáridos
Giardiasis
Antiparasitarios
Terapias Complementarias
dc.subject.fr.en_US.fl_str_mv Camomille
Polyosides
Antiparasitaires
Thérapies complémentaires
Synergie
dc.subject.decs.en_US.fl_str_mv Camomila
Polissacarídeos
Giardíase
Antiparasitários
Terapias Complementares
Sinergismo de Substâncias Bioativas
description Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. EVAHPI – Extracellular Vesicles and Host-Parasite Interactions Research Group. Curitiba, PR, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-02-10T14:45:20Z
dc.date.available.fl_str_mv 2023-02-10T14:45:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SABATKE, Bruna et al. Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis. Life., v. 12, n. 2091, p. 1–9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57002
dc.identifier.issn.en_US.fl_str_mv 2075-1729
dc.identifier.doi.none.fl_str_mv 10.3390/life12122091
identifier_str_mv SABATKE, Bruna et al. Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis. Life., v. 12, n. 2091, p. 1–9, 2022.
2075-1729
10.3390/life12122091
url https://www.arca.fiocruz.br/handle/icict/57002
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57002/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57002/2/life-12-02091-v2ok.pdf
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