Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain
Autor(a) principal: | |
---|---|
Data de Publicação: | 1998 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43924 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. |
id |
CRUZ_35f7e8f54a901759ce00e40f4b979682 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/43924 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Pacheco, Raquel S.Ferreira, Marcelo S.Machado, Maria InêsBrito, Célia M. M.Pires, Marize Q.Cruz, Alda M. daCoutinho, Sergio G.2020-10-11T20:23:31Z2020-10-11T20:23:31Z1998PACHECO, Raquel S. et al. Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 2, p. 185-169, Mar./Apr. 1998.0074-0276https://www.arca.fiocruz.br/handle/icict/4392410.1590/S0074-027619980002000051678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Doença de ChagasTrypanosoma cruziInfecção oportunistaCo-infecção por AIDSReativaçãoChagas’ diseaseAIDS co-infectionOpportunistic infectionTrypanosoma cruziReactivationChagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Straininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Uberlândia. Departamento de Patologia. Uberlândia, MG, Brasil.Universidade Federal de Uberlândia. Departamento de Patologia. Uberlândia, MG, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sérgio Arouca. Departamento de Ciências Biológicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil.In the past few years, new aspects of the immunopathology of Chagas’ disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description of the genotypic characterization, at the strain level, of Trypanosoma cruzi isolated from a patient with Chagas‘ disease/AIDS co-infection. The presence of four hypodense lesions was observed in the cranial compute tomographic scan. The diagnosis of AIDS was assessed by the detection of anti-HIV antibodies using enzyme-linked immunosorbent assay (ELISA) and Western blot techniques. The CD4+ lymphocyte counts were maintained under 200 cells/mm3 during one year demonstrating the severity of the state of immunosuppression. Chagas’ disease was confirmed by serological and parasitological methods. Trypomastigote forms were visualized in a thick blood smear. The parasite isolated is genotypically similar to the CL strain. The paper reinforces that cerebral Chagas’ disease can be considered as another potential opportunistic infection in AIDS resulting from the reactivation of a dormant T. cruzi infection acquired years earlier.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43924/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRaquelPacheco_AldaMCruz_etal_IOC_1998.pdfRaquelPacheco_AldaMCruz_etal_IOC_1998.pdfapplication/pdf159600https://www.arca.fiocruz.br/bitstream/icict/43924/2/RaquelPacheco_AldaMCruz_etal_IOC_1998.pdfe0bf567f40cb01830bae49e74f361fe5MD52TEXTRaquelPacheco_AldaMCruz_etal_IOC_1998.pdf.txtRaquelPacheco_AldaMCruz_etal_IOC_1998.pdf.txtExtracted texttext/plain21800https://www.arca.fiocruz.br/bitstream/icict/43924/3/RaquelPacheco_AldaMCruz_etal_IOC_1998.pdf.txta221e1d66e4d8d7ba8660077cd87c63eMD53icict/439242020-10-12 02:07:57.775oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-10-12T05:07:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
spellingShingle |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain Pacheco, Raquel S. Doença de Chagas Trypanosoma cruzi Infecção oportunista Co-infecção por AIDS Reativação Chagas’ disease AIDS co-infection Opportunistic infection Trypanosoma cruzi Reactivation |
title_short |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_full |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_fullStr |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_full_unstemmed |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_sort |
Chagas Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
author |
Pacheco, Raquel S. |
author_facet |
Pacheco, Raquel S. Ferreira, Marcelo S. Machado, Maria Inês Brito, Célia M. M. Pires, Marize Q. Cruz, Alda M. da Coutinho, Sergio G. |
author_role |
author |
author2 |
Ferreira, Marcelo S. Machado, Maria Inês Brito, Célia M. M. Pires, Marize Q. Cruz, Alda M. da Coutinho, Sergio G. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pacheco, Raquel S. Ferreira, Marcelo S. Machado, Maria Inês Brito, Célia M. M. Pires, Marize Q. Cruz, Alda M. da Coutinho, Sergio G. |
dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Infecção oportunista Co-infecção por AIDS Reativação |
topic |
Doença de Chagas Trypanosoma cruzi Infecção oportunista Co-infecção por AIDS Reativação Chagas’ disease AIDS co-infection Opportunistic infection Trypanosoma cruzi Reactivation |
dc.subject.en.pt_BR.fl_str_mv |
Chagas’ disease AIDS co-infection Opportunistic infection Trypanosoma cruzi Reactivation |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. |
publishDate |
1998 |
dc.date.issued.fl_str_mv |
1998 |
dc.date.accessioned.fl_str_mv |
2020-10-11T20:23:31Z |
dc.date.available.fl_str_mv |
2020-10-11T20:23:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PACHECO, Raquel S. et al. Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 2, p. 185-169, Mar./Apr. 1998. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/43924 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02761998000200005 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
PACHECO, Raquel S. et al. Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, n. 2, p. 185-169, Mar./Apr. 1998. 0074-0276 10.1590/S0074-02761998000200005 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/43924 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/43924/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/43924/2/RaquelPacheco_AldaMCruz_etal_IOC_1998.pdf https://www.arca.fiocruz.br/bitstream/icict/43924/3/RaquelPacheco_AldaMCruz_etal_IOC_1998.pdf.txt |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 e0bf567f40cb01830bae49e74f361fe5 a221e1d66e4d8d7ba8660077cd87c63e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813009040634019840 |