Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47889 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil. |
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Assis, Gabriela Maira Pereira deAlvarenga, Denise Anete Madureira dePereira, Matheus de Oliveira CostaSánchez-Arcila, Juan CamiloCosta, Anielle de PinaSouza Junior, Júlio César de SouzaNunes, Ana Julia DutraPissinatti, AlcidesMoreira, Silvia BahadianTorres, Leticia de MenezesCosta, Helena LottTinoco, Herlandes da PenhaPereira, Valéria do SocorroSoares, Irene da SilvaSouza, Taís Nóbrega deNutmngia, Francis BabilaAdams, John H.Kano, Flora SatikoHirano, Zelinda Maria BragaDaniel-Ribeiro, Claudio TadeuFerreira, Joseli OliveiraCarvalho, Luzia HelenaBrito, Cristiana Ferreira Alves de2021-06-28T12:09:59Z2021-06-28T12:09:59Z2021ASSIS, Gabriela Maria Pereira de et al. Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest. Front. Cell. Infect. Microbiol., v. 11, Article 678996, 15 p, May 2021.2235-2988https://www.arca.fiocruz.br/handle/icict/4788910.3389/fcimb.2021.678996engFrontiers MediaMaláriaImunidade HumoralPrimatas neotropicaisMata AtlânticaAntígeno pré-eritróciticoAntígenos eritróciticosMalariaHumoral responseNeotropical primatesAtlantic ForestPre-erythrocytic antigenErythrocytic antigensImunidade HumoralProfiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forestinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Ambulatório de Doenças febris, Instituto Nacional de Infectologia (INI), Ambulatório de Doenças Febris Agudas, Rio de Janeiro, RJ, Brasil / Centro Universitário Serra dos Órgãos (UNIFESO), Teresópolis, RJ, Brasil.Centro de Pesquisas Biológicas de Indaial. Indaial, SC, Brasil / Fundação Universidade Regional de Blumenau (FURB), Blumenau, SC, Brasil.Centro de Pesquisas Biológicas de Indaial. Indaial, SC, Brasil / Programa de conservação do Bugio Ruivo. Joinville, SC, Brasil.Centro Universitário Serra dos Órgãos (UNIFESO), Teresópolis, RJ, Brasil / Instituto Estadual do Ambiente (INEA). Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil.Instituto Estadual do Ambiente (INEA). Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação de Parques Municipais e Zoobotânica (FPMZB). Belo Horizonte, MG, Brasil.Fundação de Parques Municipais e Zoobotânica (FPMZB). Belo Horizonte, MG, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, USA.Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, USA.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Centro de Pesquisas Biológicas de Indaial. Indaial, SC, Brasil / Fundação Universidade Regional de Blumenau (FURB), Blumenau, SC, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. InstitutoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Human malaria due to zoonotic transmission has been recorded in the Atlantic Forest, an extra-Amazonian area in Brazil, which are a challenge for malaria control. Naturally acquired humoral immune response against pre-erythrocytic and erythrocytic antigens of Neotropical primates (NP) was evaluated here to improve the knowledge about the exposure of those animals to the malaria transmission and support the identification of the potential reservoirs of the disease in the Atlantic Forest. Blood samples of 154 monkeys from three areas of the Atlantic Forest were used to identify IgG antibodies against peptides of the repeat region of the major pre-erythrocytic antigen, the circumsporozoite protein (CSP), of Plasmodium vivax (PvCSP), Plasmodium brasilianum/Plasmodium malariae (Pb/PmCSP), and Plasmodium falciparum (PfCSP) by ELISA. Antibodies against erythrocytic recombinant antigens of P. vivax, Apical membrane antigen 1 (PvAMA-1), Erythrocyte binding protein 2 (PvEBP-2) and domain II of Duffy binding protein (PvDBPII) were also evaluated. Parameters, such as age, sex, PCR positivity, Human malaria due to zoonotic transmission has been recorded in the Atlantic Forest, an extra-Amazonian area in Brazil, which are a challenge for malaria control. Naturally acquired humoral immune response against pre-erythrocytic and erythrocytic antigens of Neotropical primates (NP) was evaluated here to improve the knowledge about the exposure of those animals to the malaria transmission and support the identification of the potential reservoirs of the disease in the Atlantic Forest. Blood samples of 154 monkeys from three areas of the Atlantic Forest were used to identify IgG antibodies against peptides of the repeat region of the major pre-erythrocytic antigen, the circumsporozoite protein (CSP), of Plasmodium vivax (PvCSP), Plasmodium brasilianum/Plasmodium malariae (Pb/PmCSP), and Plasmodium falciparum (PfCSP) by ELISA. Antibodies against erythrocytic recombinant antigens of P. vivax, Apical membrane antigen 1 (PvAMA-1), Erythrocyte binding protein 2 (PvEBP-2) and domain II of Duffy binding protein (PvDBPII) were also evaluated. Parameters, such as age, sex, PCR positivity,Human malaria due to zoonotic transmission has been recorded in the Atlantic Forest, an extra-Amazonian area in Brazil, which are a challenge for malaria control. Naturally acquired humoral immune response against pre-erythrocytic and erythrocytic antigens of Neotropical primates (NP) was evaluated here to improve the knowledge about the exposure of those animals to the malaria transmission and support the identification of the potential reservoirs of the disease in the Atlantic Forest. Blood samples of 154 monkeys from three areas of the Atlantic Forest were used to identify IgG antibodies against peptides of the repeat region of the major pre-erythrocytic antigen, the circumsporozoite protein (CSP), of Plasmodium vivax (PvCSP), Plasmodium brasilianum/Plasmodium malariae (Pb/PmCSP), and Plasmodium falciparum (PfCSP) by ELISA. Antibodies against erythrocytic recombinant antigens of P. vivax, Apical membrane antigen 1 (PvAMA-1), Erythrocyte binding protein 2 (PvEBP-2) and domain II of Duffy binding protein (PvDBPII) were also evaluated. Parameters, such as age, sex, PCR positivity and captivity, potentially associated with humoral immune response were analyzed. Eighty-five percent of NP had antibodies against at least one CSP peptide, and 76% against at least one P. vivax erythrocytic antigen. A high percentage of adults compared to non-adults were seropositive and showed increased antibody levels. Neotropical primates with PCR positive for P. simium had a significantly higher frequency of positivity rate for immune response against PvEBP-2, PvDBPII and also higher antibody levels against PvDBPII, compared to PCR negative NPs for this species. Monkeys with PCR positive for P. brasilianum/P. malariae showed higher frequency of seropositivity and antibody levels against Pb/PmCSP. Levels of antibodies against Pb/PmCSP, PvEBP-2 and PvDBPII were higher in free-living than in captive monkeys from the same area. All Platyrrhine families showed antibodies against CSP peptides, however not all showed IgG against erythrocytic antigens. These findings showed a high prevalence of naturally acquired antibodies against CSP repeats in all studied areas, suggesting an intense exposure to infected-mosquitoes bites of NP from all families. However, mainly monkeys of Atelidae family showed antibodies against P. vivax erythrocytic antigens, suggesting blood infection, which might serve as potential reservoirs of malaria in the Atlantic Forest.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47889/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGabrielaAssis_ClaudioTDRibeiro_etal_IOC_2021.pdfGabrielaAssis_ClaudioTDRibeiro_etal_IOC_2021.pdfapplication/pdf7085630https://www.arca.fiocruz.br/bitstream/icict/47889/2/GabrielaAssis_ClaudioTDRibeiro_etal_IOC_2021.pdf5c64e94852860f7013b02a62f70de6e1MD52TEXTGabrielaAssis_ClaudioTDRibeiro_etal_IOC_2021.pdf.txtGabrielaAssis_ClaudioTDRibeiro_etal_IOC_2021.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| title |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| spellingShingle |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest Assis, Gabriela Maira Pereira de Malária Imunidade Humoral Primatas neotropicais Mata Atlântica Antígeno pré-eritrócitico Antígenos eritróciticos Malaria Humoral response Neotropical primates Atlantic Forest Pre-erythrocytic antigen Erythrocytic antigens Imunidade Humoral |
| title_short |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| title_full |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| title_fullStr |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| title_full_unstemmed |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| title_sort |
Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest |
| author |
Assis, Gabriela Maira Pereira de |
| author_facet |
Assis, Gabriela Maira Pereira de Alvarenga, Denise Anete Madureira de Pereira, Matheus de Oliveira Costa Sánchez-Arcila, Juan Camilo Costa, Anielle de Pina Souza Junior, Júlio César de Souza Nunes, Ana Julia Dutra Pissinatti, Alcides Moreira, Silvia Bahadian Torres, Leticia de Menezes Costa, Helena Lott Tinoco, Herlandes da Penha Pereira, Valéria do Socorro Soares, Irene da Silva Souza, Taís Nóbrega de Nutmngia, Francis Babila Adams, John H. Kano, Flora Satiko Hirano, Zelinda Maria Braga Daniel-Ribeiro, Claudio Tadeu Ferreira, Joseli Oliveira Carvalho, Luzia Helena Brito, Cristiana Ferreira Alves de |
| author_role |
author |
| author2 |
Alvarenga, Denise Anete Madureira de Pereira, Matheus de Oliveira Costa Sánchez-Arcila, Juan Camilo Costa, Anielle de Pina Souza Junior, Júlio César de Souza Nunes, Ana Julia Dutra Pissinatti, Alcides Moreira, Silvia Bahadian Torres, Leticia de Menezes Costa, Helena Lott Tinoco, Herlandes da Penha Pereira, Valéria do Socorro Soares, Irene da Silva Souza, Taís Nóbrega de Nutmngia, Francis Babila Adams, John H. Kano, Flora Satiko Hirano, Zelinda Maria Braga Daniel-Ribeiro, Claudio Tadeu Ferreira, Joseli Oliveira Carvalho, Luzia Helena Brito, Cristiana Ferreira Alves de |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Assis, Gabriela Maira Pereira de Alvarenga, Denise Anete Madureira de Pereira, Matheus de Oliveira Costa Sánchez-Arcila, Juan Camilo Costa, Anielle de Pina Souza Junior, Júlio César de Souza Nunes, Ana Julia Dutra Pissinatti, Alcides Moreira, Silvia Bahadian Torres, Leticia de Menezes Costa, Helena Lott Tinoco, Herlandes da Penha Pereira, Valéria do Socorro Soares, Irene da Silva Souza, Taís Nóbrega de Nutmngia, Francis Babila Adams, John H. Kano, Flora Satiko Hirano, Zelinda Maria Braga Daniel-Ribeiro, Claudio Tadeu Ferreira, Joseli Oliveira Carvalho, Luzia Helena Brito, Cristiana Ferreira Alves de |
| dc.subject.other.pt_BR.fl_str_mv |
Malária Imunidade Humoral Primatas neotropicais Mata Atlântica Antígeno pré-eritrócitico Antígenos eritróciticos |
| topic |
Malária Imunidade Humoral Primatas neotropicais Mata Atlântica Antígeno pré-eritrócitico Antígenos eritróciticos Malaria Humoral response Neotropical primates Atlantic Forest Pre-erythrocytic antigen Erythrocytic antigens Imunidade Humoral |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Humoral response Neotropical primates Atlantic Forest Pre-erythrocytic antigen Erythrocytic antigens |
| dc.subject.decs.pt_BR.fl_str_mv |
Imunidade Humoral |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil. |
| publishDate |
2021 |
| dc.date.accessioned.fl_str_mv |
2021-06-28T12:09:59Z |
| dc.date.available.fl_str_mv |
2021-06-28T12:09:59Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ASSIS, Gabriela Maria Pereira de et al. Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest. Front. Cell. Infect. Microbiol., v. 11, Article 678996, 15 p, May 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/47889 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2021.678996 |
| identifier_str_mv |
ASSIS, Gabriela Maria Pereira de et al. Profiling Humoral Immune Response Against Pre-Erythrocytic and Erythrocytic Antigens of Malaria Parasites Among Neotropical Primates in the Brazilian Atlantic Forest. Front. Cell. Infect. Microbiol., v. 11, Article 678996, 15 p, May 2021. 2235-2988 10.3389/fcimb.2021.678996 |
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https://www.arca.fiocruz.br/handle/icict/47889 |
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eng |
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Frontiers Media |
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Frontiers Media |
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Repositório Institucional da FIOCRUZ (ARCA) |
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repositorio.arca@fiocruz.br |
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