IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/61076 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil. |
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Assis, Gabriela Maíra Pereira deAlvarenga, Denise Anete Madureira deSouza, Luisa Braga eSánchez-Arcila, Juan CamiloSilva, Eduardo Fernandes ePina-Costa, Anielle deGonçalves, Gustavo Henrique PereiraJunior Souza, Júlio César deNunes, Ana Julia DutraPissinatti, AlcidesMoreira, Silvia BahadianTorres, Leticia de MenezesCosta, Helena LottTinoco, Herlandes da PenhaPereira, Valéria do SocorroSoares, Irene da SilvaSousa, Taís Nóbrega deNtumngia, Francis BabilaAdams, John H.Kano, Flora SatikoHirano, Zelinda Maria BragaPratt-Riccio, Lilian RoseDaniel-Ribeiro, Cláudio TadeuFerreira, Joseli OliveiraCarvalho, Luzia HelenaBrito, Cristiana Ferreira Alves de2023-11-07T18:19:48Z2023-11-07T18:19:48Z2023ASSIS, Gabriela Maíra Pereira de et al. IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest. Frontiers in Cellular and Infection Microbiology, v. 13, p. 1-16, 2023.2235-2988https://www.arca.fiocruz.br/handle/icict/6107610.3389/fcimb.2023.1169552engFrontiers MediaIgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forestinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.School of Natural Sciences. Molecular and Cell Biology Department. University of California. Merced, Merced, CA, USA.Fundação Oswaldo Cruz. Instituto René Rachou. Vice-diretoria de Ensino. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brazil / Universidade Federal Fluminense. Escola de Enfermagem Aurora de Afonso Costa. Departamento de Doenças infecciosas e Parasitárias. Niterói, RJ, Brazil.Fundação Universidade Regional de Blumenau. Blumenau, SC, Brazil / Centro de Pesquisas Biológicas de Indaial. Indaial, SP, Brazil.Fundação Universidade Regional de Blumenau. Blumenau, SC, Brazil.Fundação Universidade Regional de Blumenau. Blumenau, SC, Brazil / Centro de Pesquisas Biológicas de Indaial. Indaial, SP, Brazil / Programa de conservação do Bugio Ruivo. Perini Business Park. Joinville, SC, Brazil.Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brazil / Centro Universitário Serra dos Órgãos. Teresópolis, RJ, Brazil.Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Prefeitura de Belo Horizonte. Fundação de Parques Municipais e Zoobotânica. Belo Horizonte, MG, Brazil.Prefeitura de Belo Horizonte. Fundação de Parques Municipais e Zoobotânica. Belo Horizonte, MG, Brazil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Center for Global Health and Infectious Diseases Research. College of Public Health. University of South Florida. Tampa, FL, USA.Center for Global Health and Infectious Diseases Research. College of Public Health. University of South Florida. Tampa, FL, USA.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Fundação Universidade Regional de Blumenau. Blumenau, SC, Brazil/Centro de Pesquisas Biológicas de Indaial. Indaial, SP, Brazil / Programa de conservação do Bugio Ruivo. Perini Business Park. Joinville, SC, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil.Introduction: Zoonotic transmission is a challenge for the control and elimination of malaria. It has been recorded in the Atlantic Forest, outside the Amazon which is the endemic region in Brazil. However, only very few studies have assessed the antibody response, especially of IgM antibodies, in Neotropical primates (NP). Therefore, in order to contribute to a better understanding of the immune response in different hosts and facilitate the identification of potential reservoirs, in this study, naturally acquired IgM antibody responses against Plasmodium antigens were evaluated, for the first time, in NP from the Atlantic Forest. Methods: The study was carried out using 154 NP samples from three different areas of the Atlantic Forest. IgM antibodies against peptides of the circumsporozoite protein (CSP) from different Plasmodium species and different erythrocytic stage antigens were detected by ELISA. Results: Fifty-nine percent of NP had IgM antibodies against at least one CSP peptide and 87% against at least one Plasmodium vivax erythrocytic stage antigen. Levels of antibodies against PvAMA-1 were the highest compared to the other antigens. All families of NP showed IgM antibodies against CSP peptides, and, most strikingly, against erythrocytic stage antigens. Generalized linear models demonstrated that IgM positivity against PvCSP and PvAMA-1 was associated with PCR-detectable blood-stage malaria infection and the host being free-living. Interestingly, animals with IgM against both PvCSP and PvAMA-1 were 4.7 times more likely to be PCR positive than animals that did not have IgM for these two antigens simultaneously. Discussion: IgM antibodies against different Plasmodium spp. antigens are present in NP from the Atlantic Forest. High seroprevalence and antibody levels against blood-stage antigens were observed, which had a significant association with molecular evidence of infection. IgM antibodies against CSP and AMA-1 may be used as a potential marker for the identification of NP infected with Plasmodium, which are reservoirs of malaria in the Brazilian Atlantic Forest.MalariaPlasmodiumIgM antibodiesNeotropical primatesAtlantic forestPreerythrocytic stage antigenErythrocytic stage antigensinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/61076/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALImG Antibody.pdfImG Antibody.pdfapplication/pdf3857118https://www.arca.fiocruz.br/bitstream/icict/61076/2/ImG%20Antibody.pdfcdd9873a2fc488921f3c2496843bedf1MD52icict/610762023-11-08 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| dc.title.en_US.fl_str_mv |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| title |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| spellingShingle |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest Assis, Gabriela Maíra Pereira de Malaria Plasmodium IgM antibodies Neotropical primates Atlantic forest Preerythrocytic stage antigen Erythrocytic stage antigens |
| title_short |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| title_full |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| title_fullStr |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| title_full_unstemmed |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| title_sort |
IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest |
| author |
Assis, Gabriela Maíra Pereira de |
| author_facet |
Assis, Gabriela Maíra Pereira de Alvarenga, Denise Anete Madureira de Souza, Luisa Braga e Sánchez-Arcila, Juan Camilo Silva, Eduardo Fernandes e Pina-Costa, Anielle de Gonçalves, Gustavo Henrique Pereira Junior Souza, Júlio César de Nunes, Ana Julia Dutra Pissinatti, Alcides Moreira, Silvia Bahadian Torres, Leticia de Menezes Costa, Helena Lott Tinoco, Herlandes da Penha Pereira, Valéria do Socorro Soares, Irene da Silva Sousa, Taís Nóbrega de Ntumngia, Francis Babila Adams, John H. Kano, Flora Satiko Hirano, Zelinda Maria Braga Pratt-Riccio, Lilian Rose Daniel-Ribeiro, Cláudio Tadeu Ferreira, Joseli Oliveira Carvalho, Luzia Helena Brito, Cristiana Ferreira Alves de |
| author_role |
author |
| author2 |
Alvarenga, Denise Anete Madureira de Souza, Luisa Braga e Sánchez-Arcila, Juan Camilo Silva, Eduardo Fernandes e Pina-Costa, Anielle de Gonçalves, Gustavo Henrique Pereira Junior Souza, Júlio César de Nunes, Ana Julia Dutra Pissinatti, Alcides Moreira, Silvia Bahadian Torres, Leticia de Menezes Costa, Helena Lott Tinoco, Herlandes da Penha Pereira, Valéria do Socorro Soares, Irene da Silva Sousa, Taís Nóbrega de Ntumngia, Francis Babila Adams, John H. Kano, Flora Satiko Hirano, Zelinda Maria Braga Pratt-Riccio, Lilian Rose Daniel-Ribeiro, Cláudio Tadeu Ferreira, Joseli Oliveira Carvalho, Luzia Helena Brito, Cristiana Ferreira Alves de |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Assis, Gabriela Maíra Pereira de Alvarenga, Denise Anete Madureira de Souza, Luisa Braga e Sánchez-Arcila, Juan Camilo Silva, Eduardo Fernandes e Pina-Costa, Anielle de Gonçalves, Gustavo Henrique Pereira Junior Souza, Júlio César de Nunes, Ana Julia Dutra Pissinatti, Alcides Moreira, Silvia Bahadian Torres, Leticia de Menezes Costa, Helena Lott Tinoco, Herlandes da Penha Pereira, Valéria do Socorro Soares, Irene da Silva Sousa, Taís Nóbrega de Ntumngia, Francis Babila Adams, John H. Kano, Flora Satiko Hirano, Zelinda Maria Braga Pratt-Riccio, Lilian Rose Daniel-Ribeiro, Cláudio Tadeu Ferreira, Joseli Oliveira Carvalho, Luzia Helena Brito, Cristiana Ferreira Alves de |
| dc.subject.en.none.fl_str_mv |
Malaria Plasmodium IgM antibodies Neotropical primates Atlantic forest Preerythrocytic stage antigen Erythrocytic stage antigens |
| topic |
Malaria Plasmodium IgM antibodies Neotropical primates Atlantic forest Preerythrocytic stage antigen Erythrocytic stage antigens |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da malária. Belo Horizonte, MG, Brazil. |
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2023 |
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2023-11-07T18:19:48Z |
| dc.date.available.fl_str_mv |
2023-11-07T18:19:48Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ASSIS, Gabriela Maíra Pereira de et al. IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest. Frontiers in Cellular and Infection Microbiology, v. 13, p. 1-16, 2023. |
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https://www.arca.fiocruz.br/handle/icict/61076 |
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2235-2988 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2023.1169552 |
| identifier_str_mv |
ASSIS, Gabriela Maíra Pereira de et al. IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest. Frontiers in Cellular and Infection Microbiology, v. 13, p. 1-16, 2023. 2235-2988 10.3389/fcimb.2023.1169552 |
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