Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis

Detalhes bibliográficos
Autor(a) principal: Batista, Leandro
Data de Publicação: 2020
Outros Autores: Jouvion, Gregory, Simon-Chazottes, Dominique, Houzelstein, Denis, Burlen-Defranoux, Odile, Boissière, Magali, Tokuda, Satoko, Valle, Tania Zaverucha do, Cumano, Ana, Flamand, Marie, Montagutelli, Xavier, Panthier, Jean-Jacques
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42513
Resumo: Institut Pasteur. Mouse Functional Genetics. Paris, France / Sorbonne Université, IFD. Paris, France.
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spelling Batista, LeandroJouvion, GregorySimon-Chazottes, DominiqueHouzelstein, DenisBurlen-Defranoux, OdileBoissière, MagaliTokuda, SatokoValle, Tania Zaverucha doCumano, AnaFlamand, MarieMontagutelli, XavierPanthier, Jean-Jacques2020-08-03T19:13:16Z2020-08-03T19:13:16Z2020BATISTA, Leandro et al. Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis. Scientific Reports, v. 10, p. 1-12, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4251310.1038/s41598-020-65683-wengNature ResearchDissecação genéticaRift Valley patogêneseFebreHepatite de início precoceCromossomo 11Genetic dissectionRift Valley fever pathogenesisMouse chromosomeEarly-onset hepatitisSurviveGenetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitut Pasteur. Mouse Functional Genetics. Paris, France / Sorbonne Université, IFD. Paris, France.Institut Pasteur. Experimental Neuropathology. Paris, France / Sorbonne Université, INSERM, Physiopathologie des Maladies Génétiques d’Expression Pédiatrique, APHP, Hôpital Armand Trousseau. UF de Génétique Moléculaire, Paris, France.Institut Pasteur. Mouse Functional Genetics. Paris, France / Institut Pasteur. Mouse Genetics. Paris, France.Institut Pasteur. Mouse Functional Genetics. Paris, France.Institut Pasteur. Lymphopoiesis. Paris, France.Institut Pasteur. Structural Virology. Paris, France.Institut Pasteur. Mouse Functional Genetics. Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Institut Pasteur. Lymphopoiesis. Paris, France.Institut Pasteur. Structural Virology. Paris, France.Institut Pasteur. Mouse Functional Genetics. Paris, France / Institut Pasteur. Mouse Genetics. Paris, France.Institut Pasteur. Mouse Functional Genetics. Paris, France.Infection of mice with Rift Valley fever virus (RVFV) reproduces major pathological features of severe human disease, notably the early-onset hepatitis and delayed-onset encephalitis. We previously reported that the Rvfs2 locus from the susceptible MBT/Pas strain reduces survival time after RVFV infection. Here, we used BALB/cByJ (BALB) mice congenic for Rvfs2 (C.MBT-Rvfs2) to investigate the pathophysiological mechanisms impacted by Rvfs2. Clinical, biochemical and histopathological features indicated similar liver damage in BALB and C.MBT-Rvfs2 mice until day 5 after infection. However, while C.MBT-Rvfs2 mice succumbed from acute liver injury, most BALB mice recovered and died later of encephalitis. Hepatocytes of BALB infected liver proliferated actively on day 6, promoting organ regeneration and recovery from liver damage. By comparison with C.MBT-Rvfs2, BALB mice had up to 100-fold lower production of infectious virions in the peripheral blood and liver, strongly decreased RVFV protein in liver and reduced viral replication in primary cultured hepatocytes, suggesting that the BALB Rvfs2 haplotype limits RVFV pathogenicity through decreased virus replication. Moreover, bone marrow chimera experiments showed that both hematopoietic and non-hematopoietic cells are required for the protective effect of the BALB Rvfs2 haplotype. Altogether, these results indicate that Rvfs2 controls critical events which allow survival to RVFV-induced hepatitis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42513/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTaniaZaverucha_Valle_etal_IOC_2020.pdfTaniaZaverucha_Valle_etal_IOC_2020.pdfapplication/pdf3567371https://www.arca.fiocruz.br/bitstream/icict/42513/2/TaniaZaverucha_Valle_etal_IOC_2020.pdfc82552edee9e09b40ff1b49e28f186dfMD52TEXTTaniaZaverucha_Valle_etal_IOC_2020.pdf.txtTaniaZaverucha_Valle_etal_IOC_2020.pdf.txtExtracted texttext/plain55242https://www.arca.fiocruz.br/bitstream/icict/42513/3/TaniaZaverucha_Valle_etal_IOC_2020.pdf.txtd00e7433121caba2fced3f18db824acbMD53icict/425132020-09-29 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dc.title.pt_BR.fl_str_mv Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
title Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
spellingShingle Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
Batista, Leandro
Dissecação genética
Rift Valley patogênese
Febre
Hepatite de início precoce
Cromossomo 11
Genetic dissection
Rift Valley fever pathogenesis
Mouse chromosome
Early-onset hepatitis
Survive
title_short Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
title_full Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
title_fullStr Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
title_full_unstemmed Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
title_sort Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis
author Batista, Leandro
author_facet Batista, Leandro
Jouvion, Gregory
Simon-Chazottes, Dominique
Houzelstein, Denis
Burlen-Defranoux, Odile
Boissière, Magali
Tokuda, Satoko
Valle, Tania Zaverucha do
Cumano, Ana
Flamand, Marie
Montagutelli, Xavier
Panthier, Jean-Jacques
author_role author
author2 Jouvion, Gregory
Simon-Chazottes, Dominique
Houzelstein, Denis
Burlen-Defranoux, Odile
Boissière, Magali
Tokuda, Satoko
Valle, Tania Zaverucha do
Cumano, Ana
Flamand, Marie
Montagutelli, Xavier
Panthier, Jean-Jacques
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Leandro
Jouvion, Gregory
Simon-Chazottes, Dominique
Houzelstein, Denis
Burlen-Defranoux, Odile
Boissière, Magali
Tokuda, Satoko
Valle, Tania Zaverucha do
Cumano, Ana
Flamand, Marie
Montagutelli, Xavier
Panthier, Jean-Jacques
dc.subject.other.pt_BR.fl_str_mv Dissecação genética
Rift Valley patogênese
Febre
Hepatite de início precoce
Cromossomo 11
topic Dissecação genética
Rift Valley patogênese
Febre
Hepatite de início precoce
Cromossomo 11
Genetic dissection
Rift Valley fever pathogenesis
Mouse chromosome
Early-onset hepatitis
Survive
dc.subject.en.pt_BR.fl_str_mv Genetic dissection
Rift Valley fever pathogenesis
Mouse chromosome
Early-onset hepatitis
Survive
description Institut Pasteur. Mouse Functional Genetics. Paris, France / Sorbonne Université, IFD. Paris, France.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-03T19:13:16Z
dc.date.available.fl_str_mv 2020-08-03T19:13:16Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BATISTA, Leandro et al. Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis. Scientific Reports, v. 10, p. 1-12, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42513
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-020-65683-w
identifier_str_mv BATISTA, Leandro et al. Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis. Scientific Reports, v. 10, p. 1-12, 2020.
2045-2322
10.1038/s41598-020-65683-w
url https://www.arca.fiocruz.br/handle/icict/42513
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/42513/2/TaniaZaverucha_Valle_etal_IOC_2020.pdf
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