The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice

Detalhes bibliográficos
Autor(a) principal: Tokuda, S.
Data de Publicação: 2016
Outros Autores: Valle, T. Z. do, Batista, L., Simon-Chazottes, D., Guillemot, L., Bouloy, M., Flamand, M., Montagutelli, X., Panthier, J. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19520
Resumo: Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.
id CRUZ_6b587f8ee14146e8af8437f25ae2b0c0
oai_identifier_str oai:www.arca.fiocruz.br:icict/19520
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Tokuda, S.Valle, T. Z. doBatista, L.Simon-Chazottes, D.Guillemot, L.Bouloy, M.Flamand, M.Montagutelli, X.Panthier, J. J.2017-06-27T12:55:30Z2017-06-27T12:55:30Z2016TOKUDA, S. et al. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice. Open Access Hybrid Model Option B. v.16, n.3, p.206-12, 2016.1466-4879https://www.arca.fiocruz.br/handle/icict/195201476-5470engNature Publishing GroupFebre do Vale de RiftBase genéticaRatosRiRift Valley feverMicegenetic basisThe genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Prtozoologia. Rio de Janeiro, RJ, Brasil.Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France / Sorbonne Universités. UPMC Univ Paris 06, IFD, F-75006. Paris, France.Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.Institut Pasteur. Bunyaviruses Molecular Genetics. F-75015 Paris, France.Institut Pasteur. Structural Virology. F-75015 Paris, France.Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.The large variation in individual response to infection with Rift Valley fever virus 3 (RVFV) suggests that host genetic determinants play a role in determining virus4 induced disease outcomes. These genetic factors are still unknown. The systemic 5 inoculation of mice with RVFV reproduces major pathological features of severe 6 human disease, notably the hepatitis and encephalitis. A genome scan performed 7 on 546 (BALB/c  MBT) F2 progeny identified three quantitative trait loci (QTLs), 8 denoted Rvfs-1 to Rvfs-3, that were associated with disease susceptibility in 9 MBT/Pas mice. Non parametric interval-mapping revealed one significant and two 10 suggestive linkages with survival time on chromosomes 2 (Rvfs-1), 5 (Rvfs-3), and 11 11 (Rvfs-2) with respective LOD scores of 4.58, 2.95 and 2.99. The two-part model, 12 combining survival time and survival/death, identified one significant linkage to 13 Rvfs-2 and one suggestive linkage to Rvfs-1 with respective LOD scores of 5.12 and 14 4.55. Under a multiple model, with additive effects and sex as a covariate, the three 15 QTLs explained 8.3 % of the phenotypic variance. Sex had the strongest influence 16 on susceptibility. The contribution of Rvfs-1, Rvfs-2, and Rvfs-3 to survival time of 17 RVFV-infected mice was further confirmed in congenic mice.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19520/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTzaverucha_valley_etal_IOC_2016.pdfTzaverucha_valley_etal_IOC_2016.pdfapplication/pdf4952724https://www.arca.fiocruz.br/bitstream/icict/19520/2/Tzaverucha_valley_etal_IOC_2016.pdf28a6d76946488a897f8fa4c08e4289b4MD52TEXTTzaverucha_valley_etal_IOC_2016.pdf.txtTzaverucha_valley_etal_IOC_2016.pdf.txtExtracted texttext/plain44744https://www.arca.fiocruz.br/bitstream/icict/19520/3/Tzaverucha_valley_etal_IOC_2016.pdf.txt85e96725f904d0b27058ddc5b321ee0aMD53icict/195202018-08-15 03:16:03.908oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T06:16:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
title The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
spellingShingle The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
Tokuda, S.
Febre do Vale de Rift
Base genética
Ratos
RiRift Valley fever
Mice
genetic basis
title_short The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
title_full The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
title_fullStr The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
title_full_unstemmed The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
title_sort The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice
author Tokuda, S.
author_facet Tokuda, S.
Valle, T. Z. do
Batista, L.
Simon-Chazottes, D.
Guillemot, L.
Bouloy, M.
Flamand, M.
Montagutelli, X.
Panthier, J. J.
author_role author
author2 Valle, T. Z. do
Batista, L.
Simon-Chazottes, D.
Guillemot, L.
Bouloy, M.
Flamand, M.
Montagutelli, X.
Panthier, J. J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tokuda, S.
Valle, T. Z. do
Batista, L.
Simon-Chazottes, D.
Guillemot, L.
Bouloy, M.
Flamand, M.
Montagutelli, X.
Panthier, J. J.
dc.subject.other.pt_BR.fl_str_mv Febre do Vale de Rift
Base genética
Ratos
topic Febre do Vale de Rift
Base genética
Ratos
RiRift Valley fever
Mice
genetic basis
dc.subject.en.pt_BR.fl_str_mv RiRift Valley fever
Mice
genetic basis
description Institut Pasteur. Developmental & Stem Cell Biology Department. Mouse functional Genetics. F-75015, Paris, France / Centre National de la Recherche Scientifique. URA 2578, F-75015 Paris, France.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-06-27T12:55:30Z
dc.date.available.fl_str_mv 2017-06-27T12:55:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TOKUDA, S. et al. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice. Open Access Hybrid Model Option B. v.16, n.3, p.206-12, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19520
dc.identifier.issn.pt_BR.fl_str_mv 1466-4879
dc.identifier.eissn.none.fl_str_mv 1476-5470
identifier_str_mv TOKUDA, S. et al. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice. Open Access Hybrid Model Option B. v.16, n.3, p.206-12, 2016.
1466-4879
1476-5470
url https://www.arca.fiocruz.br/handle/icict/19520
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/19520/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/19520/2/Tzaverucha_valley_etal_IOC_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/19520/3/Tzaverucha_valley_etal_IOC_2016.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
28a6d76946488a897f8fa4c08e4289b4
85e96725f904d0b27058ddc5b321ee0a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008966967361536

Registros relacionados