Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1986
Outros Autores: Grimaud, Jean Alexis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14613
Resumo: Fundação Gonçalo Moniz, Instituto de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Sonia GumesGrimaud, Jean Alexis2016-06-27T13:33:03Z2016-07-07T11:39:51Z2016-06-27T13:33:03Z2016-07-07T11:39:51Z1986ANDRADE, S. G.; GRIMAUD, J. A. Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix. Memórias do Instituto Oswaldo Crux, v. 81, n. 1, p. 29-41, 1986.0074-0276https://www.arca.fiocruz.br/handle/icict/14613engInstituto Oswaldo CruzChronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrixinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Instituto de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstitut Pasteur de Lyon. Lyon, FranceIn na attempt to define the mouse-model for chronic Chagas' disease, a serological, histopathological and ultrastructural study as well as immunotyping of myocardium collagenic matrix were performed on Swiss mice, chronically infected with Trypanosoma cruzi strains: 21 SF and Mambaí (Type II); PMN and Bolívia (Type III), spontaneously surviving after 154 to 468days of infection. Haemagglutination and indirect immunofluorescence tests showed high titres of specific antibodies. The ultrastructural study disclosed the cellular constitution of the inflammatory infiltrate showing the predominance of monocytes, macrophages with intense phagocytic activity, fibroblasts, myofibroblasts and abundant collagen matrix suggesting the association of the inflammatory process with fibrogenesis in chronic chagasic cardiomyopathy. Arteriolar and blood capillary alterations together with dissociation of cardiac cells from the capillaty wall by edema and inflammation were related to ultrastructural lesions of myocardial cells. Rupture of parasitized cardiac myocells contribute to intensify the inflammatory process in focal areas. Collagen immunotyping showed the predominance of Types III and IV collagen. Collagen degradation and phagocytosis were presente suggesting a reversibility of the fibrous process. The mouse model seems to be valuble in the study of the pathogenetic mechanisms in Chagas cardiomyopathy, providing that T. cruzi strains of low virulence and high pathogenecity are used.Trypanosoma cruziChronic experimental T. cruzi infectionMouse model of chronic T. cruziChronic myocarditisCollagen immunolabellingUltrastructural myocardialinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAndrade SG Chronic murine....pdf.txtAndrade SG Chronic murine....pdf.txtExtracted texttext/plain13https://www.arca.fiocruz.br/bitstream/icict/14613/4/Andrade%20SG%20Chronic%20murine....pdf.txt67e866c735744ec6037b77b623ee022dMD54ORIGINALAndrade SG Chronic 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dc.title.pt_BR.fl_str_mv Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
title Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
spellingShingle Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
Andrade, Sonia Gumes
Trypanosoma cruzi
Chronic experimental T. cruzi infection
Mouse model of chronic T. cruzi
Chronic myocarditis
Collagen immunolabelling
Ultrastructural myocardial
title_short Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
title_full Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
title_fullStr Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
title_full_unstemmed Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
title_sort Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
Grimaud, Jean Alexis
author_role author
author2 Grimaud, Jean Alexis
author2_role author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
Grimaud, Jean Alexis
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chronic experimental T. cruzi infection
Mouse model of chronic T. cruzi
Chronic myocarditis
Collagen immunolabelling
Ultrastructural myocardial
topic Trypanosoma cruzi
Chronic experimental T. cruzi infection
Mouse model of chronic T. cruzi
Chronic myocarditis
Collagen immunolabelling
Ultrastructural myocardial
description Fundação Gonçalo Moniz, Instituto de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1986
dc.date.issued.fl_str_mv 1986
dc.date.accessioned.fl_str_mv 2016-06-27T13:33:03Z
2016-07-07T11:39:51Z
dc.date.available.fl_str_mv 2016-06-27T13:33:03Z
2016-07-07T11:39:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, S. G.; GRIMAUD, J. A. Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix. Memórias do Instituto Oswaldo Crux, v. 81, n. 1, p. 29-41, 1986.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14613
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, S. G.; GRIMAUD, J. A. Chronic murine myocarditis due to Trypanosoma Cruzi - an ultrasctructural study an immunochemical characterization of cardiac interstitial matrix. Memórias do Instituto Oswaldo Crux, v. 81, n. 1, p. 29-41, 1986.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/14613
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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