Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice

Detalhes bibliográficos
Autor(a) principal: Coutinho, Elsimar M
Data de Publicação: 1997
Outros Autores: Souza, Márcia Maria de, Silva, Luciana M, Cavalcanti, C. L, Araújo, Roni Evencio de, Barbosa Junior, Aryon de Almeida, Cheever, Allen W., Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12805
Resumo: Fundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Recide, Pe, Brasil
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spelling Coutinho, Elsimar MSouza, Márcia Maria deSilva, Luciana MCavalcanti, C. LAraújo, Roni Evencio deBarbosa Junior, Aryon de AlmeidaCheever, Allen W.Andrade, Zilton de Araújo2016-02-25T14:00:51Z2016-02-25T14:00:51Z1997COUTINHO, E. M. et al. Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice. International Journal of Experimental PAthology, v. 78, p. 337-342, 1997.0959-9673https://www.arca.fiocruz.br/handle/icict/12805engBlackwell PublishingPathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Recide, Pe, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Recide, Pe, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Recide, Pe, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMice maintained on a low protein diet for 30 days and then infected with Schistosoma mansoni for 16 weeks-completely failed to develop 'pipestem fibrosis' of the liver, whereas 50% of well nourished controls did. Usually mice with relatively mild and prolonged S. mansoni infection develop two diferente pathological pictures: one consisting of disseminated portal fibrosis caused by periovular granulomas concentrated at the portal spaces (pipestem fibrosis), the other represented by scattered hepatic granulomas. The reason for this dual response is poorley understood. Combined results from parasitological, histopathological, biochemical and morphometric data revealed that peri-ovular granulomas of undermourished mice were smaller, inflammation was less intense and there was minimal fibrosisi in comparison with those of controls, which suggest that a vigorou host response is necessary for the pathogenesis of schistosomal portal fibrosisPipestem fibrosisSchistosomiasisPeriovular granulomaUndernutritioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12805/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCoutinho E Pathogenesis....pdfCoutinho E Pathogenesis....pdfapplication/pdf218245https://www.arca.fiocruz.br/bitstream/icict/12805/2/Coutinho%20E%20Pathogenesis....pdf6c20ad21b6a34e86e7af82b8734a3cbaMD52TEXTCoutinho E Pathogenesis....pdf.txtCoutinho E 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dc.title.pt_BR.fl_str_mv Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
title Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
spellingShingle Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
Coutinho, Elsimar M
Pipestem fibrosis
Schistosomiasis
Periovular granuloma
Undernutrition
title_short Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
title_full Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
title_fullStr Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
title_full_unstemmed Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
title_sort Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice
author Coutinho, Elsimar M
author_facet Coutinho, Elsimar M
Souza, Márcia Maria de
Silva, Luciana M
Cavalcanti, C. L
Araújo, Roni Evencio de
Barbosa Junior, Aryon de Almeida
Cheever, Allen W.
Andrade, Zilton de Araújo
author_role author
author2 Souza, Márcia Maria de
Silva, Luciana M
Cavalcanti, C. L
Araújo, Roni Evencio de
Barbosa Junior, Aryon de Almeida
Cheever, Allen W.
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Coutinho, Elsimar M
Souza, Márcia Maria de
Silva, Luciana M
Cavalcanti, C. L
Araújo, Roni Evencio de
Barbosa Junior, Aryon de Almeida
Cheever, Allen W.
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Pipestem fibrosis
Schistosomiasis
Periovular granuloma
Undernutrition
topic Pipestem fibrosis
Schistosomiasis
Periovular granuloma
Undernutrition
description Fundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Recide, Pe, Brasil
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2016-02-25T14:00:51Z
dc.date.available.fl_str_mv 2016-02-25T14:00:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COUTINHO, E. M. et al. Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice. International Journal of Experimental PAthology, v. 78, p. 337-342, 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12805
dc.identifier.issn.none.fl_str_mv 0959-9673
identifier_str_mv COUTINHO, E. M. et al. Pathogenesis of schistosomal 'pipestem' fibrosis: a low-protein diet inhibits the development of 'pipesten' fibrosis in mice. International Journal of Experimental PAthology, v. 78, p. 337-342, 1997.
0959-9673
url https://www.arca.fiocruz.br/handle/icict/12805
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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