Autophagy in protists and their hosts: When, how and why?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1080/27694127.2022.2149211 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58193 |
Resumo: | Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina. |
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Romano, Patricia SilviaAkematsu, TakahikoBesteiro, SébastienBindschedler, AnninaCarruthers, Vern B.Chahine, ZeinabCoppens, IsabelleDescoteaux, AlbertDuque, Thabata Lopes AlbertoHe, Cynthia Y.Heussler, VolkerLe Roch, Karine G.Li, Feng-JunMenezes, Juliana Perrone Bezerra deMenna- Barreto, Rubem Figueiredo SadokMottram, Jeremy C.Schmuckli-Maurer, JacquelineTurk, BorisVeras, Patricia Sampaio TavaresSalassa, Betiana NebaiVanrell, María Cristina2023-05-07T15:59:03Z2023-05-07T15:59:03Z2023ROMANO, Patricia Silva et al. Autophagy in protists and their hosts: When, how and why? Autophagy Reports, v. 2, n. 1, 2149211, p. 1-109, Mar. 2023.1554-8627https://www.arca.fiocruz.br/handle/icict/5819310.1080/27694127.2022.2149211engTaylor & FrancisAutofagiaProtistasVida útilLeishmania sp.Plasmodium sp.Toxoplasma gondiiTrypanosoma bruceiTrypanosoma cruziAutophagyProtistsLife-cycleLeishmania sp.Plasmodium sp.Tripanosoma bruceiTripanosoma cruziToxoplasma gondiiAutophagy in protists and their hosts: When, how and why?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLaboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina.Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo, Japan.LPHI, Univ Montpellier, CNRS, Montpellier, France.Institute of Cell Biology.University of Bern. Baltzerstr, Bern, Switzerland.Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI, USA.Department of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA.Department of Molecular Microbiology and Immunology. Johns Hopkins Malaria Research Institute. Johns Hopkins University Bloomberg School of Public Health. Baltimore, MD, USA.Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada.Autophagy Inflammation and Metabolism Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA / Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.Autophagy Inflammation and Metabolism Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA / Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.Department of Biological Sciences, National University of Singapore, Singapore.Institute of Cell Biology.University of Bern. Baltzerstr, Bern, Switzerland.Department of Biological Sciences, National University of Singapore, Singapore.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Laboratory of Host-Parasite Interaction and Epidemiology. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.York Biomedical Research Institute, Department of Biology, University of York, York, UK.Department of Biochemistry and Molecular and Structural Biology. Jožef Stefan Institute. Ljubljana, Slovenian.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Laboratory of Host-Parasite Interaction and Epidemiology. Salvador, BA, Brazil / National Institute of Science and Technology of Tropical Diseases. National Council for Scientific Research and Development, Brasil.Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina.Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina.Pathogenic protists are a group of organisms responsible for causing a variety of human diseases including malaria, sleeping sickness, Chagas disease, leishmaniasis, and toxoplasmosis, among others. These diseases, which affect more than one billion people globally, mainly the poorest populations, are character ized by severe chronic stages and the lack of effective antiparasitic treatment. Parasitic protists display complex life-cycles and go through different cellular transformations in order to adapt to the different hosts they live in. Autophagy, a highly conserved cellular degradation process, has emerged as a key ism required for these differentiation processes, as well as other functions that are crucial to parasite fitness. In contrast to yeasts and mammals, protist autophagy is characterized by a modest number of conserved autophagy- related proteins (ATGs) that, even though, can drive the autophagosome mation and degradation. In addition, during their intracellular cycle, the action of these pathogens with the host autophagy system plays a crucial role resulting in a beneficial or harmful effect that is important for the outcome of the infection. In this review, we summarize the current state of knowledge on autophagy and other related mechanisms in pathogenic protists and their hosts. We sought to emphasize when, how, and why this process takes place, and the effects it may have on the parasitic cycle. A better understanding of the significance of autophagy for the protist life-cycle will potentially be helpful to design novel anti-parasitic strategies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58193/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRubemFigueiredoMennaBarreto_etal_IOC_2023.pdfRubemFigueiredoMennaBarreto_etal_IOC_2023.pdfapplication/pdf10784098https://www.arca.fiocruz.br/bitstream/icict/58193/2/RubemFigueiredoMennaBarreto_etal_IOC_2023.pdffbdcda738e53f527681f9668b98d6ee8MD52icict/581932023-09-14 15:53:36.407oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:53:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Autophagy in protists and their hosts: When, how and why? |
| title |
Autophagy in protists and their hosts: When, how and why? |
| spellingShingle |
Autophagy in protists and their hosts: When, how and why? Romano, Patricia Silvia Autofagia Protistas Vida útil Leishmania sp. Plasmodium sp. Toxoplasma gondii Trypanosoma brucei Trypanosoma cruzi Autophagy Protists Life-cycle Leishmania sp. Plasmodium sp. Tripanosoma brucei Tripanosoma cruzi Toxoplasma gondii |
| title_short |
Autophagy in protists and their hosts: When, how and why? |
| title_full |
Autophagy in protists and their hosts: When, how and why? |
| title_fullStr |
Autophagy in protists and their hosts: When, how and why? |
| title_full_unstemmed |
Autophagy in protists and their hosts: When, how and why? |
| title_sort |
Autophagy in protists and their hosts: When, how and why? |
| author |
Romano, Patricia Silvia |
| author_facet |
Romano, Patricia Silvia Akematsu, Takahiko Besteiro, Sébastien Bindschedler, Annina Carruthers, Vern B. Chahine, Zeinab Coppens, Isabelle Descoteaux, Albert Duque, Thabata Lopes Alberto He, Cynthia Y. Heussler, Volker Le Roch, Karine G. Li, Feng-Jun Menezes, Juliana Perrone Bezerra de Menna- Barreto, Rubem Figueiredo Sadok Mottram, Jeremy C. Schmuckli-Maurer, Jacqueline Turk, Boris Veras, Patricia Sampaio Tavares Salassa, Betiana Nebai Vanrell, María Cristina |
| author_role |
author |
| author2 |
Akematsu, Takahiko Besteiro, Sébastien Bindschedler, Annina Carruthers, Vern B. Chahine, Zeinab Coppens, Isabelle Descoteaux, Albert Duque, Thabata Lopes Alberto He, Cynthia Y. Heussler, Volker Le Roch, Karine G. Li, Feng-Jun Menezes, Juliana Perrone Bezerra de Menna- Barreto, Rubem Figueiredo Sadok Mottram, Jeremy C. Schmuckli-Maurer, Jacqueline Turk, Boris Veras, Patricia Sampaio Tavares Salassa, Betiana Nebai Vanrell, María Cristina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Romano, Patricia Silvia Akematsu, Takahiko Besteiro, Sébastien Bindschedler, Annina Carruthers, Vern B. Chahine, Zeinab Coppens, Isabelle Descoteaux, Albert Duque, Thabata Lopes Alberto He, Cynthia Y. Heussler, Volker Le Roch, Karine G. Li, Feng-Jun Menezes, Juliana Perrone Bezerra de Menna- Barreto, Rubem Figueiredo Sadok Mottram, Jeremy C. Schmuckli-Maurer, Jacqueline Turk, Boris Veras, Patricia Sampaio Tavares Salassa, Betiana Nebai Vanrell, María Cristina |
| dc.subject.other.en_US.fl_str_mv |
Autofagia Protistas Vida útil Leishmania sp. Plasmodium sp. Toxoplasma gondii Trypanosoma brucei Trypanosoma cruzi |
| topic |
Autofagia Protistas Vida útil Leishmania sp. Plasmodium sp. Toxoplasma gondii Trypanosoma brucei Trypanosoma cruzi Autophagy Protists Life-cycle Leishmania sp. Plasmodium sp. Tripanosoma brucei Tripanosoma cruzi Toxoplasma gondii |
| dc.subject.en.en_US.fl_str_mv |
Autophagy Protists Life-cycle Leishmania sp. Plasmodium sp. Tripanosoma brucei Tripanosoma cruzi Toxoplasma gondii |
| description |
Laboratorio de Biología de Trypanosoma cruzi y de la célula hospedadora. Instituto de Histología y Embriología de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza, Argentina. |
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2023 |
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2023-05-07T15:59:03Z |
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2023-05-07T15:59:03Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ROMANO, Patricia Silva et al. Autophagy in protists and their hosts: When, how and why? Autophagy Reports, v. 2, n. 1, 2149211, p. 1-109, Mar. 2023. |
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https://www.arca.fiocruz.br/handle/icict/58193 |
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1554-8627 |
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10.1080/27694127.2022.2149211 |
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ROMANO, Patricia Silva et al. Autophagy in protists and their hosts: When, how and why? Autophagy Reports, v. 2, n. 1, 2149211, p. 1-109, Mar. 2023. 1554-8627 10.1080/27694127.2022.2149211 |
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Taylor & Francis |
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Taylor & Francis |
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