Human Kinetoplastid Protozoan Infections: Where Are We Going Next?

Detalhes bibliográficos
Autor(a) principal: Filardy, Alessandra Almeida
Data de Publicação: 2018
Outros Autores: Pinto, Kamila Guimarães, Nunes, Marise Pinheiro, Zukeram, Ketiuce, Fliess, Lara, Pereira, Ludimila, Nascimento, Danielle Oliveira, Conde, Luciana, Morrot, Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31474
Resumo: Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Filardy, Alessandra AlmeidaPinto, Kamila GuimarãesNunes, Marise PinheiroZukeram, KetiuceFliess, LaraPereira, LudimilaNascimento, Danielle OliveiraConde, LucianaMorrot, Alexandre2019-02-07T12:59:38Z2019-02-07T12:59:38Z2018FILARDY, Alessandra Almeida et al. Human Kinetoplastid Protozoan Infections: Where are we going next?. Frontiers in Immunology, v. 9, p. 1-7, July 2018.1664-3224https://www.arca.fiocruz.br/handle/icict/3147410.3389/fimmu.2018.01493engFrontiers MediaTrypanosoma cruziLeishmaniaTrypanosoma bruceiProtozoários kinetoplastidInfecção parasitáriaParasitic infectionKinetoplastid protozoansTrypanosoma cruziLeishmaniaTrypanosoma bruceiHuman Kinetoplastid Protozoan Infections: Where Are We Going Next?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Centro de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil.Kinetoplastida trypanosomatidae microorganisms are protozoan parasites exhibiting a developmental stage in the gut of insect vectors and tissues of vertebrate hosts. During the vertebrate infective stages, these parasites alter the differential expression of virulence genes, modifying their biological and antigenic properties in order to subvert the host protective immune responses and establish a persistent infection. One of the hallmarks of kinetoplastid parasites is their evasion mechanisms from host immunity, leading to disease chronification. The diseases caused by kinetoplastid parasites are neglected by the global expenditures in research and development, affecting millions of individuals in the low and middle-income countries located mainly in the tropical and subtropical regions. However, investments made by public and private initiatives have over the past decade leveraged important lines of intervention that if well-integrated to health care programs will likely accelerate disease control initiatives. This review summarizes recent advances in public health care principles, including new drug discoveries and their rational use with chemotherapeutic vaccines, and the implementation of control efforts to spatially mapping the kinetoplastid infections through monitoring of infected individuals in epidemic areas. These approaches should bring us the means to track genetic variation of parasites and drug resistance, integrating this knowledge into effective stewardship programs to prevent vector-borne kinetoplastid infections in areas at risk of disease spreading.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31474/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarisenunes_alexandremorrto_etal_IOC_2018.pdfmarisenunes_alexandremorrto_etal_IOC_2018.pdfapplication/pdf920561https://www.arca.fiocruz.br/bitstream/icict/31474/2/marisenunes_alexandremorrto_etal_IOC_2018.pdf9ed75f91a5b649a7c8fe637233782bf2MD52TEXTmarisenunes_alexandremorrto_etal_IOC_2018.pdf.txtmarisenunes_alexandremorrto_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
title Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
spellingShingle Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
Filardy, Alessandra Almeida
Trypanosoma cruzi
Leishmania
Trypanosoma brucei
Protozoários kinetoplastid
Infecção parasitária
Parasitic infection
Kinetoplastid protozoans
Trypanosoma cruzi
Leishmania
Trypanosoma brucei
title_short Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
title_full Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
title_fullStr Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
title_full_unstemmed Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
title_sort Human Kinetoplastid Protozoan Infections: Where Are We Going Next?
author Filardy, Alessandra Almeida
author_facet Filardy, Alessandra Almeida
Pinto, Kamila Guimarães
Nunes, Marise Pinheiro
Zukeram, Ketiuce
Fliess, Lara
Pereira, Ludimila
Nascimento, Danielle Oliveira
Conde, Luciana
Morrot, Alexandre
author_role author
author2 Pinto, Kamila Guimarães
Nunes, Marise Pinheiro
Zukeram, Ketiuce
Fliess, Lara
Pereira, Ludimila
Nascimento, Danielle Oliveira
Conde, Luciana
Morrot, Alexandre
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Filardy, Alessandra Almeida
Pinto, Kamila Guimarães
Nunes, Marise Pinheiro
Zukeram, Ketiuce
Fliess, Lara
Pereira, Ludimila
Nascimento, Danielle Oliveira
Conde, Luciana
Morrot, Alexandre
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Leishmania
Trypanosoma brucei
Protozoários kinetoplastid
Infecção parasitária
topic Trypanosoma cruzi
Leishmania
Trypanosoma brucei
Protozoários kinetoplastid
Infecção parasitária
Parasitic infection
Kinetoplastid protozoans
Trypanosoma cruzi
Leishmania
Trypanosoma brucei
dc.subject.en.pt_BR.fl_str_mv Parasitic infection
Kinetoplastid protozoans
Trypanosoma cruzi
Leishmania
Trypanosoma brucei
description Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-07T12:59:38Z
dc.date.available.fl_str_mv 2019-02-07T12:59:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FILARDY, Alessandra Almeida et al. Human Kinetoplastid Protozoan Infections: Where are we going next?. Frontiers in Immunology, v. 9, p. 1-7, July 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31474
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2018.01493
identifier_str_mv FILARDY, Alessandra Almeida et al. Human Kinetoplastid Protozoan Infections: Where are we going next?. Frontiers in Immunology, v. 9, p. 1-7, July 2018.
1664-3224
10.3389/fimmu.2018.01493
url https://www.arca.fiocruz.br/handle/icict/31474
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31474/1/license.txt
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