Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42241 |
Resumo: | Research Program of the Institute Gonçalo Moniz, Fundação Oswaldo Cruz, Brazil. Valéria M. Borges and Bruno B. Andrade are senior scientist fellows from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Ney Boa-Sorte received a fellowship from Fundação Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). Caian L. Vinhaes and Hayna Malta-Santos received a fellowship from the CNPq. Jéssica Rebouças-Silva received a fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (finance code 001). |
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Barretto, Junaura RBoa-Sorte, NeyVinhaes, Caian LSantos, Hayna MaltaRamos, Camila FNascimento, Monica A. S. TorresBorges, Valeria de MatodAndrade, Bruno de Bezerril2020-07-14T12:18:04Z2020-07-14T12:18:04Z2020BARRETTO, Junaura R. et al. Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study. Nutrients, v. 12, p. 1650, 2020.2072-6643https://www.arca.fiocruz.br/handle/icict/4224110.3390/nu12061650Research Program of the Institute Gonçalo Moniz, Fundação Oswaldo Cruz, Brazil. Valéria M. Borges and Bruno B. Andrade are senior scientist fellows from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Ney Boa-Sorte received a fellowship from Fundação Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). Caian L. Vinhaes and Hayna Malta-Santos received a fellowship from the CNPq. Jéssica Rebouças-Silva received a fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (finance code 001).Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Fima Lifshitz Metabolic Unit. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Fima Lifshitz Metabolic Unit. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.Nonalcoholic Fatty Liver Disease (NAFLD) is a common cause of chronic liver disease in childhood and strongly associated with obesity. Routine biochemical non-invasive tests remain with low accuracy for diagnosis of NAFLD. We performed a cross-sectional study to examine potential associations between anthropometric and biochemical parameters, specially TGF-β, a prognosis marker for hepatic steatosis (HS). Between May and October 2019, seventy-two overweight adolescents were enrolled, of which 36 had hepatic steatosis. Hepatic, lipidic and glycemic profiles, and levels of vitamin D, ferritin and TGF-β were analyzed. Hierarchical cluster and a discriminant model using canonical correlations were employed to depict the overall expression profile of biochemical markers and the biochemical degree of perturbation. Median values of alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), and TGF-β were higher in the adolescents with HS. Values of body mass index (BMI)/age and ALT, but not of TGF-β, were gradually increased proportionally to augmentation of steatosis severity. In a multivariate analysis, TGF-β plasma concentrations were associated with occurrence of hepatic steatosis independent of other covariates. Discriminant analysis confirmed that TGF-β concentrations can identify HS cases. Our data reveal that HS patients exhibit a distinct biosignature of biochemical parameters and imply TGF-β as an important biomarker to evaluate risk of steatosis development.engMDPIDoença hepática gordurosa não alcoólicaObesidade pediátricaFator de crescimento transformador betaTransaminasesEstudos transversaisNon-alcoholic fatty liver diseasePediatric obesityTransforming growth factor betaSystemic biochemical perturbationTransaminasesCross-sectional studiesHeightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42241/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarreto. 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| dc.title.pt_BR.fl_str_mv |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| title |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| spellingShingle |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study Barretto, Junaura R Doença hepática gordurosa não alcoólica Obesidade pediátrica Fator de crescimento transformador beta Transaminases Estudos transversais Non-alcoholic fatty liver disease Pediatric obesity Transforming growth factor beta Systemic biochemical perturbation Transaminases Cross-sectional studies |
| title_short |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| title_full |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| title_fullStr |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| title_full_unstemmed |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| title_sort |
Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study |
| author |
Barretto, Junaura R |
| author_facet |
Barretto, Junaura R Boa-Sorte, Ney Vinhaes, Caian L Santos, Hayna Malta Ramos, Camila F Nascimento, Monica A. S. Torres Borges, Valeria de Matod Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Boa-Sorte, Ney Vinhaes, Caian L Santos, Hayna Malta Ramos, Camila F Nascimento, Monica A. S. Torres Borges, Valeria de Matod Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barretto, Junaura R Boa-Sorte, Ney Vinhaes, Caian L Santos, Hayna Malta Ramos, Camila F Nascimento, Monica A. S. Torres Borges, Valeria de Matod Andrade, Bruno de Bezerril |
| dc.subject.other.pt_BR.fl_str_mv |
Doença hepática gordurosa não alcoólica Obesidade pediátrica Fator de crescimento transformador beta Transaminases Estudos transversais |
| topic |
Doença hepática gordurosa não alcoólica Obesidade pediátrica Fator de crescimento transformador beta Transaminases Estudos transversais Non-alcoholic fatty liver disease Pediatric obesity Transforming growth factor beta Systemic biochemical perturbation Transaminases Cross-sectional studies |
| dc.subject.en.pt_BR.fl_str_mv |
Non-alcoholic fatty liver disease Pediatric obesity Transforming growth factor beta Systemic biochemical perturbation Transaminases Cross-sectional studies |
| description |
Research Program of the Institute Gonçalo Moniz, Fundação Oswaldo Cruz, Brazil. Valéria M. Borges and Bruno B. Andrade are senior scientist fellows from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Ney Boa-Sorte received a fellowship from Fundação Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). Caian L. Vinhaes and Hayna Malta-Santos received a fellowship from the CNPq. Jéssica Rebouças-Silva received a fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (finance code 001). |
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2020 |
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2020-07-14T12:18:04Z |
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2020-07-14T12:18:04Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BARRETTO, Junaura R. et al. Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study. Nutrients, v. 12, p. 1650, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42241 |
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2072-6643 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/nu12061650 |
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BARRETTO, Junaura R. et al. Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study. Nutrients, v. 12, p. 1650, 2020. 2072-6643 10.3390/nu12061650 |
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