Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42601 |
Resumo: | Novos diidroisoxazóis (5a-d) derivado de eugenol foram sintetizados em bons rendimentos, e suas atividades antibacteriana, antifúngica e antioxidante foram avaliadas. Todos os diidroisoxazóis foram caracterizados usando análises elementar e espectral. Todos os compostos foram avaliados contra seis bactérias ATCC padrão: Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris and Proteus mirabilis. O composto mais ativo exibiu atividade antibacteriana contra E. coli (73 μg.mL-1) and S. aureus (54 μg.mL-1). Entretanto, nenhum dos compostos apresentou atividade contra as cepas de fungos (Candida albicans, Candida krusei, Candida parapsilosis and Aspergillus fumigatus) avaliadas. Todos os diidroisoxazóis sintetizados apresentaram melhores resultados como antioxidante comparado a referência (Trolox). |
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Putarov, Nathalia BortolatoCruz, Jacqueline SantosCarvalho, Erika Martins deMendonça, Danielle Silva deSampaio, André Luiz FrancoNogueira, Joseli Maria da RochaCosta, Gisela Lara daAguiar, Alcino Palermo de2020-08-08T19:54:08Z2020-08-08T19:54:08Z2020PUTAROV, Nathalia Bortolato et al. Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol. Revista Virtual de Química, v. 12, n. 2, p. 345-355, 2020.1984-6835https://www.arca.fiocruz.br/handle/icict/4260110.21577/1984-6835.20200027Novos diidroisoxazóis (5a-d) derivado de eugenol foram sintetizados em bons rendimentos, e suas atividades antibacteriana, antifúngica e antioxidante foram avaliadas. Todos os diidroisoxazóis foram caracterizados usando análises elementar e espectral. Todos os compostos foram avaliados contra seis bactérias ATCC padrão: Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris and Proteus mirabilis. O composto mais ativo exibiu atividade antibacteriana contra E. coli (73 μg.mL-1) and S. aureus (54 μg.mL-1). Entretanto, nenhum dos compostos apresentou atividade contra as cepas de fungos (Candida albicans, Candida krusei, Candida parapsilosis and Aspergillus fumigatus) avaliadas. Todos os diidroisoxazóis sintetizados apresentaram melhores resultados como antioxidante comparado a referência (Trolox).The four novel dihydroisoxazoles (5a-d) derived from eugenol were synthesized with good yields, and their antibacterial, antifungal and antioxidant activities were evaluated. All synthesized dihydroisoxazoles were characterized using spectral and elemental analyses. All compounds were tested against six standard ATCC bacteria: Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris and Proteus mirabilis. The most active compound exhibited antibacterial activity against E. coli (73 μg.mL-1) and S. aureus (54 μg.mL-1). However, none of the compounds showed activity against the fungus strains (Candida albicans, Candida krusei, Candida parapsilosis and Aspergillus fumigatus) assayed. All the synthesized dihydroisoxazoles presented better results as antioxidants than the reference (trolox).Instituto Militar de Engenharia. Seção de Engenharia Química. Laboratório de Síntese Orgânica. Rio de Janeiro, RJ, Brasil.Instituto Militar de Engenharia. Seção de Engenharia Química. Laboratório de Síntese Orgânica. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Instituto Militar de Engenharia. Seção de Engenharia Química. Laboratório de Síntese Orgânica. Rio de Janeiro, RJ, Brasil.engSociedade Brasileira de QuímicaDiidroisoxazolEugenol antibacterianoAntioxidanteAntifúngicoDihydroisoxazoleEugenolAntibacterialAntioxidantAntifungalSynthesis and Bioactivity Screening of Dihydroisoxazoles Derived from EugenolSíntese e Avaliação da Bioatividade de Diidroisoxazóis Derivados do Eugenolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| dc.title.alternative.pt_BR.fl_str_mv |
Síntese e Avaliação da Bioatividade de Diidroisoxazóis Derivados do Eugenol |
| title |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| spellingShingle |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol Putarov, Nathalia Bortolato Diidroisoxazol Eugenol antibacteriano Antioxidante Antifúngico Dihydroisoxazole Eugenol Antibacterial Antioxidant Antifungal |
| title_short |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| title_full |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| title_fullStr |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| title_full_unstemmed |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| title_sort |
Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol |
| author |
Putarov, Nathalia Bortolato |
| author_facet |
Putarov, Nathalia Bortolato Cruz, Jacqueline Santos Carvalho, Erika Martins de Mendonça, Danielle Silva de Sampaio, André Luiz Franco Nogueira, Joseli Maria da Rocha Costa, Gisela Lara da Aguiar, Alcino Palermo de |
| author_role |
author |
| author2 |
Cruz, Jacqueline Santos Carvalho, Erika Martins de Mendonça, Danielle Silva de Sampaio, André Luiz Franco Nogueira, Joseli Maria da Rocha Costa, Gisela Lara da Aguiar, Alcino Palermo de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Putarov, Nathalia Bortolato Cruz, Jacqueline Santos Carvalho, Erika Martins de Mendonça, Danielle Silva de Sampaio, André Luiz Franco Nogueira, Joseli Maria da Rocha Costa, Gisela Lara da Aguiar, Alcino Palermo de |
| dc.subject.other.pt_BR.fl_str_mv |
Diidroisoxazol Eugenol antibacteriano Antioxidante Antifúngico |
| topic |
Diidroisoxazol Eugenol antibacteriano Antioxidante Antifúngico Dihydroisoxazole Eugenol Antibacterial Antioxidant Antifungal |
| dc.subject.en.pt_BR.fl_str_mv |
Dihydroisoxazole Eugenol Antibacterial Antioxidant Antifungal |
| description |
Novos diidroisoxazóis (5a-d) derivado de eugenol foram sintetizados em bons rendimentos, e suas atividades antibacteriana, antifúngica e antioxidante foram avaliadas. Todos os diidroisoxazóis foram caracterizados usando análises elementar e espectral. Todos os compostos foram avaliados contra seis bactérias ATCC padrão: Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris and Proteus mirabilis. O composto mais ativo exibiu atividade antibacteriana contra E. coli (73 μg.mL-1) and S. aureus (54 μg.mL-1). Entretanto, nenhum dos compostos apresentou atividade contra as cepas de fungos (Candida albicans, Candida krusei, Candida parapsilosis and Aspergillus fumigatus) avaliadas. Todos os diidroisoxazóis sintetizados apresentaram melhores resultados como antioxidante comparado a referência (Trolox). |
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2020 |
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2020-08-08T19:54:08Z |
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2020-08-08T19:54:08Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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PUTAROV, Nathalia Bortolato et al. Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol. Revista Virtual de Química, v. 12, n. 2, p. 345-355, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42601 |
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1984-6835 |
| dc.identifier.doi.none.fl_str_mv |
10.21577/1984-6835.20200027 |
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PUTAROV, Nathalia Bortolato et al. Synthesis and Bioactivity Screening of Dihydroisoxazoles Derived from Eugenol. Revista Virtual de Química, v. 12, n. 2, p. 345-355, 2020. 1984-6835 10.21577/1984-6835.20200027 |
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Sociedade Brasileira de Química |
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Sociedade Brasileira de Química |
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