Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment

Detalhes bibliográficos
Autor(a) principal: Morais, Stephanie Bath de
Data de Publicação: 2019
Outros Autores: Souza, Tatiana de Arruda Campos Brasil de
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32692
Resumo: Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
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spelling Morais, Stephanie Bath deSouza, Tatiana de Arruda Campos Brasil de2019-04-24T11:51:10Z2019-04-24T11:51:10Z2019MORAIS, S. B. de; SOUZA, T. de A. C. B. de. Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 93.https://www.arca.fiocruz.br/handle/icict/3269210.35259/isi.sact.2019_32692Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.engFiocruz/Instituto de Tecnologia em ImunobiológicosL-asparaginaseLeucemia linfoblástica agudaEngenharia de proteínasL-asparaginaseAcute lymphoblastic leukemiaProtein engineeringLeucemia Aguda BifenotípicaEngenharia de ProteínasImproving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32692/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALBIO_08.pdfapplication/pdf54273https://www.arca.fiocruz.br/bitstream/icict/32692/2/BIO_08.pdf3a4b72d096ef441e5a61bbc2f7ab38abMD52TEXTBIO_08.pdf.txtBIO_08.pdf.txtExtracted texttext/plain3878https://www.arca.fiocruz.br/bitstream/icict/32692/3/BIO_08.pdf.txtc93d5f47e5e48eec9b43e5a963e6a703MD53icict/326922023-04-26 17:00:59.139oai:www.arca.fiocruz.br:icict/32692Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T20:00:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
title Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
spellingShingle Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
Morais, Stephanie Bath de
L-asparaginase
Leucemia linfoblástica aguda
Engenharia de proteínas
L-asparaginase
Acute lymphoblastic leukemia
Protein engineering
Leucemia Aguda Bifenotípica
Engenharia de Proteínas
title_short Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
title_full Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
title_fullStr Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
title_full_unstemmed Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
title_sort Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment
author Morais, Stephanie Bath de
author_facet Morais, Stephanie Bath de
Souza, Tatiana de Arruda Campos Brasil de
author_role author
author2 Souza, Tatiana de Arruda Campos Brasil de
author2_role author
dc.contributor.author.fl_str_mv Morais, Stephanie Bath de
Souza, Tatiana de Arruda Campos Brasil de
dc.subject.other.pt_BR.fl_str_mv L-asparaginase
Leucemia linfoblástica aguda
Engenharia de proteínas
topic L-asparaginase
Leucemia linfoblástica aguda
Engenharia de proteínas
L-asparaginase
Acute lymphoblastic leukemia
Protein engineering
Leucemia Aguda Bifenotípica
Engenharia de Proteínas
dc.subject.en.pt_BR.fl_str_mv L-asparaginase
Acute lymphoblastic leukemia
Protein engineering
dc.subject.decs.pt_BR.fl_str_mv Leucemia Aguda Bifenotípica
Engenharia de Proteínas
description Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-04-24T11:51:10Z
dc.date.available.fl_str_mv 2019-04-24T11:51:10Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORAIS, S. B. de; SOUZA, T. de A. C. B. de. Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 93.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32692
dc.identifier.doi.none.fl_str_mv 10.35259/isi.sact.2019_32692
identifier_str_mv MORAIS, S. B. de; SOUZA, T. de A. C. B. de. Improving the autocleavage performance of human L-asparaginase: a novel solution to overcome the challenges of leukemia treatment. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 93.
10.35259/isi.sact.2019_32692
url https://www.arca.fiocruz.br/handle/icict/32692
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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