Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | spa |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28953 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
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Portugal, Michelle I.Todeschini, Adriane R.Lima, Cristiana S. deSilva, Carlos A. M.Borges, Ronaldo MohanaOttenhoff, Tom H. M.Previato, Lucia MendonçaPreviato, Jose O.Pessolani, Maria Cristina V.2018-09-20T17:39:19Z2018-09-20T17:39:19Z2008PORTUGAL, Michelle I. et al. Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp. BMC Microbiology, v.8:75, 10p, May 2008.1471-2180https://www.arca.fiocruz.br/handle/icict/2895310.1186/1471-2180-8-75spaBioMed CentralAdesina micobacteriana Hlpsulfato de heparanoespécie patogênicaespécie saprofistaHlpheparan sulfatepathogenic speciessaprophic speciesCharacterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlpinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Leiden University Medical Center. Department of Immunohematology and Blood Transfusion. Leiden, The Netherlands.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.The histone-like Hlp protein is emerging as a key component in mycobacterial pathogenesis, being involved in the initial events of host colonization by interacting with laminin and glycosaminoglycans (GAGs). In the present study, nuclear magnetic resonance (NMR) was used to map the binding site(s) of Hlp to heparan sulfate and identify the nature of the amino acid residues directly involved in this interaction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28953/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmichelle_portugal_etal_IOC_2008.pdfmichelle_portugal_etal_IOC_2008.pdfapplication/pdf512581https://www.arca.fiocruz.br/bitstream/icict/28953/2/michelle_portugal_etal_IOC_2008.pdff25788c4de03fb3ed23d80d51dec2fd9MD52TEXTmichelle_portugal_etal_IOC_2008.pdf.txtmichelle_portugal_etal_IOC_2008.pdf.txtExtracted texttext/plain36716https://www.arca.fiocruz.br/bitstream/icict/28953/3/michelle_portugal_etal_IOC_2008.pdf.txt67e02ea1a9ce25df199d7ccd5ca3a27bMD53icict/289532018-09-21 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| dc.title.pt_BR.fl_str_mv |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| title |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| spellingShingle |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp Portugal, Michelle I. Adesina micobacteriana Hlp sulfato de heparano espécie patogênica espécie saprofista Hlp heparan sulfate pathogenic species saprophic species |
| title_short |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| title_full |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| title_fullStr |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| title_full_unstemmed |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| title_sort |
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp |
| author |
Portugal, Michelle I. |
| author_facet |
Portugal, Michelle I. Todeschini, Adriane R. Lima, Cristiana S. de Silva, Carlos A. M. Borges, Ronaldo Mohana Ottenhoff, Tom H. M. Previato, Lucia Mendonça Previato, Jose O. Pessolani, Maria Cristina V. |
| author_role |
author |
| author2 |
Todeschini, Adriane R. Lima, Cristiana S. de Silva, Carlos A. M. Borges, Ronaldo Mohana Ottenhoff, Tom H. M. Previato, Lucia Mendonça Previato, Jose O. Pessolani, Maria Cristina V. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Portugal, Michelle I. Todeschini, Adriane R. Lima, Cristiana S. de Silva, Carlos A. M. Borges, Ronaldo Mohana Ottenhoff, Tom H. M. Previato, Lucia Mendonça Previato, Jose O. Pessolani, Maria Cristina V. |
| dc.subject.other.pt_BR.fl_str_mv |
Adesina micobacteriana Hlp sulfato de heparano espécie patogênica espécie saprofista |
| topic |
Adesina micobacteriana Hlp sulfato de heparano espécie patogênica espécie saprofista Hlp heparan sulfate pathogenic species saprophic species |
| dc.subject.en.pt_BR.fl_str_mv |
Hlp heparan sulfate pathogenic species saprophic species |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2008 |
| dc.date.issued.fl_str_mv |
2008 |
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2018-09-20T17:39:19Z |
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2018-09-20T17:39:19Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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PORTUGAL, Michelle I. et al. Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp. BMC Microbiology, v.8:75, 10p, May 2008. |
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https://www.arca.fiocruz.br/handle/icict/28953 |
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1471-2180 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/1471-2180-8-75 |
| identifier_str_mv |
PORTUGAL, Michelle I. et al. Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp. BMC Microbiology, v.8:75, 10p, May 2008. 1471-2180 10.1186/1471-2180-8-75 |
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BioMed Central |
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BioMed Central |
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