Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?

Detalhes bibliográficos
Autor(a) principal: Nader, Helena Bonciani [UNIFESP]
Data de Publicação: 1999
Outros Autores: Chavante, Suely Ferreira [UNIFESP], Santos, Elizeu Antunes dos, Oliveira, Fernanda Wanderley, Paiva, José Fernandes de [UNIFESP], Jerônimo, Selma Maria Bezerra, Medeiros, Guilherme Fulgencio de [UNIFESP], Abreu, Luiz Roberto Diz de [UNIFESP], Leite, Edda Lisboa, Sousa-Filho, João Felipe de, Castro, Rodrigo de Aquino [UNIFESP], Toma, Leny [UNIFESP], Tersariol, Ivarne Luis dos Santos [UNIFESP], Porcionatto, Marimélia Aparecida [UNIFESP], Dietrich, Carl Peter [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000006wm5
DOI: 10.1590/S0100-879X1999000500005
Texto Completo: http://dx.doi.org/10.1590/S0100-879X1999000500005
http://repositorio.unifesp.br/handle/11600/775
Resumo: The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.
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spelling Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?heparin - occurrence and functionheparan sulfate - occurrence and functionheparin - invertebratesheparan sulfate - invertebratesheparin and heparan sulfate - structureThe distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.Universidade Federal de São Paulo (UNIFESP)A02Universidade Federal do Rio Grande do NorteUniversidade de Mogi das CruzesUNIFESP, EPMSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)A02Universidade Federal do Rio Grande do NorteUniversidade de Mogi das CruzesNader, Helena Bonciani [UNIFESP]Chavante, Suely Ferreira [UNIFESP]Santos, Elizeu Antunes dosOliveira, Fernanda WanderleyPaiva, José Fernandes de [UNIFESP]Jerônimo, Selma Maria BezerraMedeiros, Guilherme Fulgencio de [UNIFESP]Abreu, Luiz Roberto Diz de [UNIFESP]Leite, Edda LisboaSousa-Filho, João Felipe deCastro, Rodrigo de Aquino [UNIFESP]Toma, Leny [UNIFESP]Tersariol, Ivarne Luis dos Santos [UNIFESP]Porcionatto, Marimélia Aparecida [UNIFESP]Dietrich, Carl Peter [UNIFESP]2015-06-14T13:24:52Z2015-06-14T13:24:52Z1999-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion529-538application/pdfhttp://dx.doi.org/10.1590/S0100-879X1999000500005Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.10.1590/S0100-879X1999000500005S0100-879X1999000500005.pdf0100-879XS0100-879X1999000500005http://repositorio.unifesp.br/handle/11600/775WOS:000080489600005ark:/48912/0013000006wm5engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T22:28:51Zoai:repositorio.unifesp.br/:11600/775Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:01:43.003959Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
title Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
spellingShingle Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Nader, Helena Bonciani [UNIFESP]
heparin - occurrence and function
heparan sulfate - occurrence and function
heparin - invertebrates
heparan sulfate - invertebrates
heparin and heparan sulfate - structure
Nader, Helena Bonciani [UNIFESP]
heparin - occurrence and function
heparan sulfate - occurrence and function
heparin - invertebrates
heparan sulfate - invertebrates
heparin and heparan sulfate - structure
title_short Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
title_full Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
title_fullStr Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
title_full_unstemmed Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
title_sort Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
author Nader, Helena Bonciani [UNIFESP]
author_facet Nader, Helena Bonciani [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Chavante, Suely Ferreira [UNIFESP]
Santos, Elizeu Antunes dos
Oliveira, Fernanda Wanderley
Paiva, José Fernandes de [UNIFESP]
Jerônimo, Selma Maria Bezerra
Medeiros, Guilherme Fulgencio de [UNIFESP]
Abreu, Luiz Roberto Diz de [UNIFESP]
Leite, Edda Lisboa
Sousa-Filho, João Felipe de
Castro, Rodrigo de Aquino [UNIFESP]
Toma, Leny [UNIFESP]
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
Chavante, Suely Ferreira [UNIFESP]
Santos, Elizeu Antunes dos
Oliveira, Fernanda Wanderley
Paiva, José Fernandes de [UNIFESP]
Jerônimo, Selma Maria Bezerra
Medeiros, Guilherme Fulgencio de [UNIFESP]
Abreu, Luiz Roberto Diz de [UNIFESP]
Leite, Edda Lisboa
Sousa-Filho, João Felipe de
Castro, Rodrigo de Aquino [UNIFESP]
Toma, Leny [UNIFESP]
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
author_role author
author2 Chavante, Suely Ferreira [UNIFESP]
Santos, Elizeu Antunes dos
Oliveira, Fernanda Wanderley
Paiva, José Fernandes de [UNIFESP]
Jerônimo, Selma Maria Bezerra
Medeiros, Guilherme Fulgencio de [UNIFESP]
Abreu, Luiz Roberto Diz de [UNIFESP]
Leite, Edda Lisboa
Sousa-Filho, João Felipe de
Castro, Rodrigo de Aquino [UNIFESP]
Toma, Leny [UNIFESP]
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
A02
Universidade Federal do Rio Grande do Norte
Universidade de Mogi das Cruzes
dc.contributor.author.fl_str_mv Nader, Helena Bonciani [UNIFESP]
Chavante, Suely Ferreira [UNIFESP]
Santos, Elizeu Antunes dos
Oliveira, Fernanda Wanderley
Paiva, José Fernandes de [UNIFESP]
Jerônimo, Selma Maria Bezerra
Medeiros, Guilherme Fulgencio de [UNIFESP]
Abreu, Luiz Roberto Diz de [UNIFESP]
Leite, Edda Lisboa
Sousa-Filho, João Felipe de
Castro, Rodrigo de Aquino [UNIFESP]
Toma, Leny [UNIFESP]
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
dc.subject.por.fl_str_mv heparin - occurrence and function
heparan sulfate - occurrence and function
heparin - invertebrates
heparan sulfate - invertebrates
heparin and heparan sulfate - structure
topic heparin - occurrence and function
heparan sulfate - occurrence and function
heparin - invertebrates
heparan sulfate - invertebrates
heparin and heparan sulfate - structure
description The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.
publishDate 1999
dc.date.none.fl_str_mv 1999-05-01
2015-06-14T13:24:52Z
2015-06-14T13:24:52Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X1999000500005
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.
10.1590/S0100-879X1999000500005
S0100-879X1999000500005.pdf
0100-879X
S0100-879X1999000500005
http://repositorio.unifesp.br/handle/11600/775
WOS:000080489600005
dc.identifier.dark.fl_str_mv ark:/48912/0013000006wm5
url http://dx.doi.org/10.1590/S0100-879X1999000500005
http://repositorio.unifesp.br/handle/11600/775
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.
10.1590/S0100-879X1999000500005
S0100-879X1999000500005.pdf
0100-879X
S0100-879X1999000500005
WOS:000080489600005
ark:/48912/0013000006wm5
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 529-538
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822219230776393728
dc.identifier.doi.none.fl_str_mv 10.1590/S0100-879X1999000500005