Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000006wm5 |
DOI: | 10.1590/S0100-879X1999000500005 |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X1999000500005 http://repositorio.unifesp.br/handle/11600/775 |
Resumo: | The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates. |
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Repositório Institucional da UNIFESP |
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Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?heparin - occurrence and functionheparan sulfate - occurrence and functionheparin - invertebratesheparan sulfate - invertebratesheparin and heparan sulfate - structureThe distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.Universidade Federal de São Paulo (UNIFESP)A02Universidade Federal do Rio Grande do NorteUniversidade de Mogi das CruzesUNIFESP, EPMSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)A02Universidade Federal do Rio Grande do NorteUniversidade de Mogi das CruzesNader, Helena Bonciani [UNIFESP]Chavante, Suely Ferreira [UNIFESP]Santos, Elizeu Antunes dosOliveira, Fernanda WanderleyPaiva, José Fernandes de [UNIFESP]Jerônimo, Selma Maria BezerraMedeiros, Guilherme Fulgencio de [UNIFESP]Abreu, Luiz Roberto Diz de [UNIFESP]Leite, Edda LisboaSousa-Filho, João Felipe deCastro, Rodrigo de Aquino [UNIFESP]Toma, Leny [UNIFESP]Tersariol, Ivarne Luis dos Santos [UNIFESP]Porcionatto, Marimélia Aparecida [UNIFESP]Dietrich, Carl Peter [UNIFESP]2015-06-14T13:24:52Z2015-06-14T13:24:52Z1999-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion529-538application/pdfhttp://dx.doi.org/10.1590/S0100-879X1999000500005Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.10.1590/S0100-879X1999000500005S0100-879X1999000500005.pdf0100-879XS0100-879X1999000500005http://repositorio.unifesp.br/handle/11600/775WOS:000080489600005ark:/48912/0013000006wm5engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T22:28:51Zoai:repositorio.unifesp.br/:11600/775Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:01:43.003959Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
spellingShingle |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? Nader, Helena Bonciani [UNIFESP] heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure Nader, Helena Bonciani [UNIFESP] heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure |
title_short |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_full |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_fullStr |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_full_unstemmed |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_sort |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
author |
Nader, Helena Bonciani [UNIFESP] |
author_facet |
Nader, Helena Bonciani [UNIFESP] Nader, Helena Bonciani [UNIFESP] Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] |
author_role |
author |
author2 |
Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) A02 Universidade Federal do Rio Grande do Norte Universidade de Mogi das Cruzes |
dc.contributor.author.fl_str_mv |
Nader, Helena Bonciani [UNIFESP] Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] |
dc.subject.por.fl_str_mv |
heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure |
topic |
heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure |
description |
The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-05-01 2015-06-14T13:24:52Z 2015-06-14T13:24:52Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X1999000500005 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999. 10.1590/S0100-879X1999000500005 S0100-879X1999000500005.pdf 0100-879X S0100-879X1999000500005 http://repositorio.unifesp.br/handle/11600/775 WOS:000080489600005 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000006wm5 |
url |
http://dx.doi.org/10.1590/S0100-879X1999000500005 http://repositorio.unifesp.br/handle/11600/775 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999. 10.1590/S0100-879X1999000500005 S0100-879X1999000500005.pdf 0100-879X S0100-879X1999000500005 WOS:000080489600005 ark:/48912/0013000006wm5 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
529-538 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1822219230776393728 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X1999000500005 |