Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pntd.0009412 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48274 |
Resumo: | Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil. |
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Castelo Branco, Rebeca CostaBrasil, PatríciaAraújo, Josélio Maria GalvãoCardoso, Flávia OliveiraBatista, Zulmira SilvaLeitão, Valéria Maria SouzaSilva, Marcos Antonio Custódio Neto daCastro, Lailson Oliveira deValverde, Joanna GardelJeronimo, Selma Maria BezerraLima, Josélia AlencarSilva, Raimunda Ribeiro daBarbosa, Maria do Carmo LacerdaBrito, Luciane Maria OliveiraXavier, Marcelo Antônio PascoalNascimento, Maria do Desterro Soares Brandão2021-07-18T13:58:09Z2021-07-18T13:58:09Z2021CASTELO BRANCO, Rebeca Costa et al. Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil. PLOS Neglected Tropical Diseases, v. 15, n. 6, e0009412, p. 1-14, Jun. 2021.1935-2727https://www.arca.fiocruz.br/handle/icict/4827410.1371/journal.pntd.0009412engPublic Library of ScienceVírus da ZikaCirculaçãoMulheres grávidas assintomáticasEvidênciasRegião NordesteBrasilZika virusCirculationAsymptomatic pregnant womenNortheastBrazilEvidenceEvidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Universidade Federal do Maranhão. Departamento de Medicina III. São Luis, MA, Brasil.Universidade Estadual de Campinas. Departamento de Pós-Graduação em Medicina Interna. Campinas, SP, Brasil.Universidade Federal do Maranhão. Faculdade de Medicina. São Luis, MA, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Bioquímica. Natal RN, Brasil / Instituto de Medicina Tropical do Rio Grande do Norte. Natal. RN, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Bioquímica. Natal RN, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Universidade Federal do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.Universidade Federal do Maranhão. Faculdade de Medicina. Departamento I. São Luis, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Background: Zika virus (ZIKV) is a flavivirus associated with microcephaly and other fetal anormalities. However, evidence of asymptomatic ZIKV infection in pregnant women is still scarce. This study investigated the prevalence of Zika infection in asymptomatic pregnant women attending two public maternities in Maranhão state, Northeast Brazil. Methods: A total of 196 women were recruited at the time of delivery by convenience sampling from two maternity clinics in São Luís, Maranhão, Brazil, between April 2017 and June 2018. Venous blood, umbilical cord blood and placental fragments from maternal and fetal sides were collected from each subject. ZIKV infection was determined by reverse transcription polymerase chain reaction (RT-qPCR) for ZIKV and by serology (IgM and IgG). Nonspecific laboratory profiles (TORCH screen) were obtained from medical records. Results: The participants were mostly from São Luı´s and were of 19–35 years of age. They had 10–15 years of schooling and they were of mixed race, married, and Catholic. ZIKV was identified in three umbilical cord samples and in nine placental fragments. Mothers with positive ZIKV RT-qPCR were in the age group older than 19 years. Of the 196 women tested by ZIKV rapid test, 6 and 117 women were positive for anti-ZIKV IgM and anti-ZIKV IgG antibodies, respectively. Placental Immunohistochemistry study detected ZIKV in all samples positive by RT-PCR. The newborns did not show any morphological and/or psychomotor abnormalities at birth. Conclusions: Asymptomatic ZIKV infection is frequent, but it was not associated to morphological and/or psychomotor abnormalities in the newborns up to 6 months post-birth. Although pathological abnormalities were not observed at birth, we cannot rule out the long term impact of apparent asymptomatic congenital ZIKV infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48274/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatrica_Brasil_etal_IOC_2021.pdfPatrica_Brasil_etal_IOC_2021.pdfapplication/pdf1617972https://www.arca.fiocruz.br/bitstream/icict/48274/2/Patrica_Brasil_etal_IOC_2021.pdfb011c538b0f86c6f01f5a91a231c7e56MD52TEXTPatrica_Brasil_etal_IOC_2021.pdf.txtPatrica_Brasil_etal_IOC_2021.pdf.txtExtracted texttext/plain43506https://www.arca.fiocruz.br/bitstream/icict/48274/3/Patrica_Brasil_etal_IOC_2021.pdf.txtdaad70be7a046e3e27da59c6f15beec5MD53icict/482742021-08-25 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| dc.title.pt_BR.fl_str_mv |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| title |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| spellingShingle |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil Castelo Branco, Rebeca Costa Vírus da Zika Circulação Mulheres grávidas assintomáticas Evidências Região Nordeste Brasil Zika virus Circulation Asymptomatic pregnant women Northeast Brazil Evidence |
| title_short |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| title_full |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| title_fullStr |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| title_full_unstemmed |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| title_sort |
Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil |
| author |
Castelo Branco, Rebeca Costa |
| author_facet |
Castelo Branco, Rebeca Costa Brasil, Patrícia Araújo, Josélio Maria Galvão Cardoso, Flávia Oliveira Batista, Zulmira Silva Leitão, Valéria Maria Souza Silva, Marcos Antonio Custódio Neto da Castro, Lailson Oliveira de Valverde, Joanna Gardel Jeronimo, Selma Maria Bezerra Lima, Josélia Alencar Silva, Raimunda Ribeiro da Barbosa, Maria do Carmo Lacerda Brito, Luciane Maria Oliveira Xavier, Marcelo Antônio Pascoal Nascimento, Maria do Desterro Soares Brandão |
| author_role |
author |
| author2 |
Brasil, Patrícia Araújo, Josélio Maria Galvão Cardoso, Flávia Oliveira Batista, Zulmira Silva Leitão, Valéria Maria Souza Silva, Marcos Antonio Custódio Neto da Castro, Lailson Oliveira de Valverde, Joanna Gardel Jeronimo, Selma Maria Bezerra Lima, Josélia Alencar Silva, Raimunda Ribeiro da Barbosa, Maria do Carmo Lacerda Brito, Luciane Maria Oliveira Xavier, Marcelo Antônio Pascoal Nascimento, Maria do Desterro Soares Brandão |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castelo Branco, Rebeca Costa Brasil, Patrícia Araújo, Josélio Maria Galvão Cardoso, Flávia Oliveira Batista, Zulmira Silva Leitão, Valéria Maria Souza Silva, Marcos Antonio Custódio Neto da Castro, Lailson Oliveira de Valverde, Joanna Gardel Jeronimo, Selma Maria Bezerra Lima, Josélia Alencar Silva, Raimunda Ribeiro da Barbosa, Maria do Carmo Lacerda Brito, Luciane Maria Oliveira Xavier, Marcelo Antônio Pascoal Nascimento, Maria do Desterro Soares Brandão |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Zika Circulação Mulheres grávidas assintomáticas Evidências Região Nordeste Brasil |
| topic |
Vírus da Zika Circulação Mulheres grávidas assintomáticas Evidências Região Nordeste Brasil Zika virus Circulation Asymptomatic pregnant women Northeast Brazil Evidence |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Circulation Asymptomatic pregnant women Northeast Brazil Evidence |
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Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil. |
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2021 |
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2021-07-18T13:58:09Z |
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2021-07-18T13:58:09Z |
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2021 |
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info:eu-repo/semantics/article |
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CASTELO BRANCO, Rebeca Costa et al. Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil. PLOS Neglected Tropical Diseases, v. 15, n. 6, e0009412, p. 1-14, Jun. 2021. |
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1935-2727 |
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10.1371/journal.pntd.0009412 |
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CASTELO BRANCO, Rebeca Costa et al. Evidence of Zika virus circulation in asymptomatic pregnant women in Northeast, Brazil. PLOS Neglected Tropical Diseases, v. 15, n. 6, e0009412, p. 1-14, Jun. 2021. 1935-2727 10.1371/journal.pntd.0009412 |
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