Animal Hosts and Experimental Models of SARS-CoV-2 Infection

Detalhes bibliográficos
Autor(a) principal: Parolin, Cristina
Data de Publicação: 2021
Outros Autores: Virtuoso, Sara, Giovanetti, Marta, Angeletti, Silvia, Ciccozzi, Massimo, Borsetti, Alessandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1159/000515341
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51423
Resumo: Department of Molecular Medicine, University of Padova. Padova, Italy.
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spelling Parolin, CristinaVirtuoso, SaraGiovanetti, MartaAngeletti, SilviaCiccozzi, MassimoBorsetti, Alessandra2022-02-23T11:15:14Z2022-02-23T11:15:14Z2021PAROLIN, Cristina et al. Animal Hosts and Experimental Models of SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9. 2021.0009-3157https://www.arca.fiocruz.br/handle/icict/5142310.1159/000515341engKargerSíndrome respiratória aguda grave coronavírus 2Hospedeiros de animaisModelos animaisModelos de célulasSevere acute respiratory syndrome coronavirus 2Animal hostsAnimal modelsCell modelsAnimal Hosts and Experimental Models of SARS-CoV-2 Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Molecular Medicine, University of Padova. Padova, Italy.National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de referência de Flavivírus. Rio de Janeiro, RJ, Brasil.Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome. Rome, Italy.Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. Rome, Italy.National HIV/AIDS Research Center, Istituto Superiore di Sanità. Rome, Italy.Viruses arise through cross-species transmission and can cause potentially fatal diseases in humans. This is the case of the severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) which recently appeared in Wuhan, China, and rapidly spread worldwide, causing the outbreak of coronavirus disease 2019 (COVID-19) and posing a global health emergency. Sequence analysis and epidemiological investigations suggest that the most likely original source of SARSCoV- 2 is a spillover from an animal reservoir, probably bats, that infected humans either directly or through intermediate animal hosts. The role of animals as reservoirs and natural hosts in SARS-CoV-2 has to be explored, and animal models for COVID-19 are needed as well to be evaluated for countermeasures against SARS-CoV-2 infection. Experimental cells, tissues, and animal models that are currently being used and developed in COVID-19 research will be presented.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51423/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCristinaParolin_MartaGiovanetti_etal_IOC_2021.pdfCristinaParolin_MartaGiovanetti_etal_IOC_2021.pdfapplication/pdf394231https://www.arca.fiocruz.br/bitstream/icict/51423/2/CristinaParolin_MartaGiovanetti_etal_IOC_2021.pdf51b32fa0c8347ba51371dbee7a1ae569MD52icict/514232023-09-05 10:15:31.667oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:15:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Animal Hosts and Experimental Models of SARS-CoV-2 Infection
title Animal Hosts and Experimental Models of SARS-CoV-2 Infection
spellingShingle Animal Hosts and Experimental Models of SARS-CoV-2 Infection
Parolin, Cristina
Síndrome respiratória aguda grave coronavírus 2
Hospedeiros de animais
Modelos animais
Modelos de células
Severe acute respiratory syndrome coronavirus 2
Animal hosts
Animal models
Cell models
title_short Animal Hosts and Experimental Models of SARS-CoV-2 Infection
title_full Animal Hosts and Experimental Models of SARS-CoV-2 Infection
title_fullStr Animal Hosts and Experimental Models of SARS-CoV-2 Infection
title_full_unstemmed Animal Hosts and Experimental Models of SARS-CoV-2 Infection
title_sort Animal Hosts and Experimental Models of SARS-CoV-2 Infection
author Parolin, Cristina
author_facet Parolin, Cristina
Virtuoso, Sara
Giovanetti, Marta
Angeletti, Silvia
Ciccozzi, Massimo
Borsetti, Alessandra
author_role author
author2 Virtuoso, Sara
Giovanetti, Marta
Angeletti, Silvia
Ciccozzi, Massimo
Borsetti, Alessandra
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Parolin, Cristina
Virtuoso, Sara
Giovanetti, Marta
Angeletti, Silvia
Ciccozzi, Massimo
Borsetti, Alessandra
dc.subject.other.pt_BR.fl_str_mv Síndrome respiratória aguda grave coronavírus 2
Hospedeiros de animais
Modelos animais
Modelos de células
topic Síndrome respiratória aguda grave coronavírus 2
Hospedeiros de animais
Modelos animais
Modelos de células
Severe acute respiratory syndrome coronavirus 2
Animal hosts
Animal models
Cell models
dc.subject.en.pt_BR.fl_str_mv Severe acute respiratory syndrome coronavirus 2
Animal hosts
Animal models
Cell models
description Department of Molecular Medicine, University of Padova. Padova, Italy.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-23T11:15:14Z
dc.date.available.fl_str_mv 2022-02-23T11:15:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAROLIN, Cristina et al. Animal Hosts and Experimental Models of SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51423
dc.identifier.issn.pt_BR.fl_str_mv 0009-3157
dc.identifier.doi.none.fl_str_mv 10.1159/000515341
identifier_str_mv PAROLIN, Cristina et al. Animal Hosts and Experimental Models of SARS-CoV-2 Infection. Chemotherapy, p. 1 - 9. 2021.
0009-3157
10.1159/000515341
url https://www.arca.fiocruz.br/handle/icict/51423
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51423/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51423/2/CristinaParolin_MartaGiovanetti_etal_IOC_2021.pdf
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