Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48513 |
Resumo: | Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil. |
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Ronchi, Daiane Cristine MartinsMalaquias, Mineia Alessandra ScaranelloRebutini, Patrícia ZadorosneiCarmo, Letícia Arianne Panini doCézar Neto, PlínioMarin, Emily ScaranelloProkopenko, AmandaNagashima, SeigoZanluca, CamilaSantos, Claudia Nunes Duarte dosNoronha, Lúcia de2021-08-09T14:13:14Z2021-08-09T14:13:14Z2021RONCHI, Daiane Cristine Martins et al. Placental morphologic similarities between ZIKV-positive and HIV- positive pregnant women. Frontiers in Immunology, v. 12, n. 684194, p. 1–7, 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/4851310.3389/fimmu.2021.684194porFrontiers MediaVírus da Imunodeficiência HumanaZika VirusInfectious Disease Transmission, VerticalAnatomic VariationTransmisión Vertical de Enfermedad InfecciosaVariación AnatómicaVirus ZikaVIHTransmission verticale de maladie infectieusePlacentaVariation anatomiqueZika virusHIVTransmissão Vertical de Doenças InfecciosasPlacentaVariação AnatômicaPlacental morphologic similarities between ZIKV-positive and HIV-positive pregnant womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil.Zika virus (ZIKV) caused global concern due to Brazil's unexpected epidemic, and it was associated with congenital microcephaly and other gestational intercurrences. The study aimed to analyze the placenta morphometric changes of ZIKV-infected pregnant women (ZIKV group; n = 23) compared to placentas of HIV-infected (HIV group; n = 24) and healthy pregnant women (N-control group; n = 22). It also analyzed the relationship between the morphometric results and pathological alterations on conventional microscopy, gestational trimester of infection, and presence of the congenital Zika syndrome (CZS). There was a significant increase in area (p = 0.0172), as well as a higher number of knots (p = 0.0027), sprouts (p < 0.0001), and CD163 +Hofbauer cells (HCs) (p < 0.0001) in the ZIKV group compared to the N-control group, suggesting that villous dysmaturity and HCs hyperplasia could be associated with ZIKV infections. The HIV group had a higher area (p < 0.0001), perimeter (p = 0.0001), sprouts (p < 0.0001), and CD163 + HCs (p < 0.0001) compared to the N-control group, demonstrating that the morphometric abnormalities found in the ZIKV and HIV group are probably similar. However, when ZIKV and HIV groups are compared, it was observed a higher number of sprouts (p = 0.0066) and CD163+ HCs (p < 0.0001) in the first one, suggesting that placental ZIKV congenital changes could be more pronounced.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/48513/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfimmu-12-684194ok.pdffimmu-12-684194ok.pdfapplication/pdf4095957https://www.arca.fiocruz.br/bitstream/icict/48513/2/fimmu-12-684194ok.pdf06f9a4fca91ba146ee903b34f8a6dd1bMD52TEXTfimmu-12-684194ok.pdf.txtfimmu-12-684194ok.pdf.txtExtracted texttext/plain36997https://www.arca.fiocruz.br/bitstream/icict/48513/3/fimmu-12-684194ok.pdf.txt28041ad9055f4e94ca077ef2f49d104aMD53icict/485132021-08-10 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| dc.title.pt_BR.fl_str_mv |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| title |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| spellingShingle |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women Ronchi, Daiane Cristine Martins Vírus da Imunodeficiência Humana Zika Virus Infectious Disease Transmission, Vertical Anatomic Variation Transmisión Vertical de Enfermedad Infecciosa Variación Anatómica Virus Zika VIH Transmission verticale de maladie infectieuse Placenta Variation anatomique Zika virus HIV Transmissão Vertical de Doenças Infecciosas Placenta Variação Anatômica |
| title_short |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| title_full |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| title_fullStr |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| title_full_unstemmed |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| title_sort |
Placental morphologic similarities between ZIKV-positive and HIV-positive pregnant women |
| author |
Ronchi, Daiane Cristine Martins |
| author_facet |
Ronchi, Daiane Cristine Martins Malaquias, Mineia Alessandra Scaranello Rebutini, Patrícia Zadorosnei Carmo, Letícia Arianne Panini do Cézar Neto, Plínio Marin, Emily Scaranello Prokopenko, Amanda Nagashima, Seigo Zanluca, Camila Santos, Claudia Nunes Duarte dos Noronha, Lúcia de |
| author_role |
author |
| author2 |
Malaquias, Mineia Alessandra Scaranello Rebutini, Patrícia Zadorosnei Carmo, Letícia Arianne Panini do Cézar Neto, Plínio Marin, Emily Scaranello Prokopenko, Amanda Nagashima, Seigo Zanluca, Camila Santos, Claudia Nunes Duarte dos Noronha, Lúcia de |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ronchi, Daiane Cristine Martins Malaquias, Mineia Alessandra Scaranello Rebutini, Patrícia Zadorosnei Carmo, Letícia Arianne Panini do Cézar Neto, Plínio Marin, Emily Scaranello Prokopenko, Amanda Nagashima, Seigo Zanluca, Camila Santos, Claudia Nunes Duarte dos Noronha, Lúcia de |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Imunodeficiência Humana |
| topic |
Vírus da Imunodeficiência Humana Zika Virus Infectious Disease Transmission, Vertical Anatomic Variation Transmisión Vertical de Enfermedad Infecciosa Variación Anatómica Virus Zika VIH Transmission verticale de maladie infectieuse Placenta Variation anatomique Zika virus HIV Transmissão Vertical de Doenças Infecciosas Placenta Variação Anatômica |
| dc.subject.en.pt_BR.fl_str_mv |
Zika Virus Infectious Disease Transmission, Vertical Anatomic Variation |
| dc.subject.es.pt_BR.fl_str_mv |
Transmisión Vertical de Enfermedad Infecciosa Variación Anatómica |
| dc.subject.fr.pt_BR.fl_str_mv |
Virus Zika VIH Transmission verticale de maladie infectieuse Placenta Variation anatomique |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika virus HIV Transmissão Vertical de Doenças Infecciosas Placenta Variação Anatômica |
| description |
Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Curitiba, PR, Brasil. |
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2021 |
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2021-08-09T14:13:14Z |
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2021-08-09T14:13:14Z |
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2021 |
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RONCHI, Daiane Cristine Martins et al. Placental morphologic similarities between ZIKV-positive and HIV- positive pregnant women. Frontiers in Immunology, v. 12, n. 684194, p. 1–7, 2021. |
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1664-3224 |
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10.3389/fimmu.2021.684194 |
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RONCHI, Daiane Cristine Martins et al. Placental morphologic similarities between ZIKV-positive and HIV- positive pregnant women. Frontiers in Immunology, v. 12, n. 684194, p. 1–7, 2021. 1664-3224 10.3389/fimmu.2021.684194 |
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