Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?

Detalhes bibliográficos
Autor(a) principal: Melgaço, Juliana Gil
Data de Publicação: 2020
Outros Autores: Azamor, Tamiris, Bom, Ana Paula Dinis Ano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41132
Resumo: Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
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spelling Melgaço, Juliana GilAzamor, TamirisBom, Ana Paula Dinis Ano2020-05-06T00:00:34Z2020-05-06T00:00:34Z2020MELGAÇO, Juliana Gil; AZAMOR, Tamiris; BOM, Ana Paula Dinis Ano. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, p. 1-7, Apr. 28 2020.0008-8749https://www.arca.fiocruz.br/handle/icict/4113210.1016/j.cellimm.2020.104114engElsevierCoronavírusCOVID-19SARS-CoV-2-IgGCoronavirusCOVID-19SARS-CoV-2-IgGProtective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/41132/1/license.txt0ab46789d568c4ba27c7b5d29a9fe9c4MD51ORIGINALMelgaço_Juliana_etal_BIO_COVID19_2020.pdfMelgaço_Juliana_etal_BIO_COVID19_2020.pdfapplication/pdf253082https://www.arca.fiocruz.br/bitstream/icict/41132/2/Melga%c3%a7o_Juliana_etal_BIO_COVID19_2020.pdf4ee9700ead14a36a261959dfd4af4184MD52TEXTMelgaço_Juliana_etal_BIO_COVID19_2020.pdf.txtMelgaço_Juliana_etal_BIO_COVID19_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
title Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
spellingShingle Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
Melgaço, Juliana Gil
Coronavírus
COVID-19
SARS-CoV-2-IgG
Coronavirus
COVID-19
SARS-CoV-2-IgG
title_short Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
title_full Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
title_fullStr Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
title_full_unstemmed Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
title_sort Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection?
author Melgaço, Juliana Gil
author_facet Melgaço, Juliana Gil
Azamor, Tamiris
Bom, Ana Paula Dinis Ano
author_role author
author2 Azamor, Tamiris
Bom, Ana Paula Dinis Ano
author2_role author
author
dc.contributor.author.fl_str_mv Melgaço, Juliana Gil
Azamor, Tamiris
Bom, Ana Paula Dinis Ano
dc.subject.other.pt_BR.fl_str_mv Coronavírus
COVID-19
SARS-CoV-2-IgG
topic Coronavírus
COVID-19
SARS-CoV-2-IgG
Coronavirus
COVID-19
SARS-CoV-2-IgG
dc.subject.en.pt_BR.fl_str_mv Coronavirus
COVID-19
SARS-CoV-2-IgG
description Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-05-06T00:00:34Z
dc.date.available.fl_str_mv 2020-05-06T00:00:34Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELGAÇO, Juliana Gil; AZAMOR, Tamiris; BOM, Ana Paula Dinis Ano. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, p. 1-7, Apr. 28 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41132
dc.identifier.issn.pt_BR.fl_str_mv 0008-8749
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.cellimm.2020.104114
identifier_str_mv MELGAÇO, Juliana Gil; AZAMOR, Tamiris; BOM, Ana Paula Dinis Ano. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, p. 1-7, Apr. 28 2020.
0008-8749
10.1016/j.cellimm.2020.104114
url https://www.arca.fiocruz.br/handle/icict/41132
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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