Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?

Detalhes bibliográficos
Autor(a) principal: Melgaço, Juliana Gil
Data de Publicação: 2020
Outros Autores: Azamor, Tamiris, Ano Bom, Ana Paula Dinis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51490
Resumo: Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
id CRUZ_d35648f7605b3fb3ab8ddccc9637d0f6
oai_identifier_str oai:www.arca.fiocruz.br:icict/51490
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Melgaço, Juliana GilAzamor, TamirisAno Bom, Ana Paula Dinis2022-02-25T14:16:20Z2022-02-25T14:16:20Z2020MELGAÇO, Juliana Gil; AZAMOR, TTamiris; ANO BOM, Ana Paula Dinis. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, n. 353, p. 1-3, Jul. 2020.0008-8749https://www.arca.fiocruz.br/handle/icict/5149010.1016/j.cellimm.2020.104114Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.O coronavírus 2 da síndrome respiratória aguda grave (SARS-CoV-2) induz uma síndrome respiratória aguda grave chamada COVID-19. As manifestações clínicas do COVID-19 incluem diarreia, pneumonia, linfopenia, linfócitos esgotados e produção de citocinas pró-inflamatórias. A imunologia faz parte do processo de evolução clínica, mas existem algumas questões em torno da proteção baseada na imunidade: (1) por que algumas pessoas infectadas apresentam apenas sintomas leves da doença ou são assintomáticas; (2) por que as respostas tardias e fracas de anticorpos estão associadas a desfechos graves; e (3) por que a positividade em testes moleculares não representa anticorpo protetor IgG. Talvez as respostas das células T possam ser a chave para resolver essas questões. As células T de memória específicas para SARS-CoV-2 persistem no sangue periférico e podem ser capazes de fornecer informações eficazes sobre imunidade protetora. Os estudos com células T podem ser úteis na elucidação dos caminhos para o desenvolvimento de vacinas, terapias e diagnósticos para COVID-19 e para preencher essas lacunas de conhecimento em imunologia.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps.Oswaldo Cruz Foundation. Immunobiological Technology Institute. Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Immunobiological Technology Institute. Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Immunobiological Technology Institute. Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.engCoronavírusCOVID-19SARS-CoV-2-IgGCoronavirusCOVID-19SARS-CoV-2-IgGCoronavírusProtective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83108https://www.arca.fiocruz.br/bitstream/icict/51490/1/license.txt155f7d692661a91111cc666068bcb611MD51ORIGINALMelgaçoa_Juliana_etal_BIOMANGUINHOS_COVID-19_2020_Artigo_Final.pdfMelgaçoa_Juliana_etal_BIOMANGUINHOS_COVID-19_2020_Artigo_Final.pdfapplication/pdf512727https://www.arca.fiocruz.br/bitstream/icict/51490/2/Melga%c3%a7oa_Juliana_etal_BIOMANGUINHOS_COVID-19_2020_Artigo_Final.pdf96c86c02d8eedf8a4be0e3e4fd8d8f6eMD52icict/514902022-03-02 19:51:00.425oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-03-02T22:51Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
title Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
spellingShingle Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
Melgaço, Juliana Gil
Coronavírus
COVID-19
SARS-CoV-2-IgG
Coronavirus
COVID-19
SARS-CoV-2-IgG
Coronavírus
title_short Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
title_full Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
title_fullStr Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
title_full_unstemmed Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
title_sort Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?
author Melgaço, Juliana Gil
author_facet Melgaço, Juliana Gil
Azamor, Tamiris
Ano Bom, Ana Paula Dinis
author_role author
author2 Azamor, Tamiris
Ano Bom, Ana Paula Dinis
author2_role author
author
dc.contributor.author.fl_str_mv Melgaço, Juliana Gil
Azamor, Tamiris
Ano Bom, Ana Paula Dinis
dc.subject.other.pt_BR.fl_str_mv Coronavírus
COVID-19
SARS-CoV-2-IgG
topic Coronavírus
COVID-19
SARS-CoV-2-IgG
Coronavirus
COVID-19
SARS-CoV-2-IgG
Coronavírus
dc.subject.en.pt_BR.fl_str_mv Coronavirus
COVID-19
SARS-CoV-2-IgG
dc.subject.decs.pt_BR.fl_str_mv Coronavírus
description Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2022-02-25T14:16:20Z
dc.date.available.fl_str_mv 2022-02-25T14:16:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELGAÇO, Juliana Gil; AZAMOR, TTamiris; ANO BOM, Ana Paula Dinis. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, n. 353, p. 1-3, Jul. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51490
dc.identifier.issn.pt_BR.fl_str_mv 0008-8749
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.cellimm.2020.104114
identifier_str_mv MELGAÇO, Juliana Gil; AZAMOR, TTamiris; ANO BOM, Ana Paula Dinis. Protective immunity after COVID-19 has been questioned: what can we do without SARS-CoV-2-IgG detection? Cellular Immunology, n. 353, p. 1-3, Jul. 2020.
0008-8749
10.1016/j.cellimm.2020.104114
url https://www.arca.fiocruz.br/handle/icict/51490
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51490/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51490/2/Melga%c3%a7oa_Juliana_etal_BIOMANGUINHOS_COVID-19_2020_Artigo_Final.pdf
bitstream.checksum.fl_str_mv 155f7d692661a91111cc666068bcb611
96c86c02d8eedf8a4be0e3e4fd8d8f6e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008889747079168

Registros relacionados