Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability

Detalhes bibliográficos
Autor(a) principal: Bravo, Bruna Souza Felix
Data de Publicação: 2015
Outros Autores: Azulay, David Rubem, Luiz, Ronir Raggio, Mandarim-De-Lacerda, Carlos Alberto, Cuzzi, Tullia, Manela-Azulay, Mônica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34726
Resumo: Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Bravo, Bruna Souza FelixAzulay, David RubemLuiz, Ronir RaggioMandarim-De-Lacerda, Carlos AlbertoCuzzi, TulliaManela-Azulay, Mônica2019-08-12T13:41:53Z2019-08-12T13:41:53Z2015BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015.0365-0596https://www.arca.fiocruz.br/handle/icict/3472610.1590/abd1806-4841.20153703Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Santa Casa de Misericórdia do Rio de Janeiro. Instituto de Dermatologia Professor Rubem David Azulay. Rio de Janeiro, RJ, Brasil / Hospital Federal da Lagoa. Rio de Janeiro, RJ, Brasil.Santa Casa de Misericórdia do Rio de Janeiro. Instituto de Dermatologia Professor Rubem David Azulay. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.BACKGROUND: The off-label use of oral isotretinoin in photoaging is a therapeutic tool that has been used by dermatologists. There are few studies to corroborate its effectiveness and durability. OBJECTIVES: To assess, both clinically and histologically, the changes caused by the use of oral isotretinoin in skin photoaging as well as the duration of the effects. METHODS: 20 female patients, aged 45-50 years, with phototypes II-VI, none of whom had experienced menopause, were treated with 20mg oral isotretinoin, 3 days a week, for 12 weeks. They underwent clinical analysis and skin biopsies in the pre-auricular region, while histologic cuts enabled assessment of the solar elastosis level and morphologic analysis. RESULTS: Clinically, patients, as well as the researching and the assessor physicians, noticed improvement in skin quality. One patient presented severe solar elastosis, 11 manifested the moderate form, while 8 presented the discreet type. According to histological analysis, 65% of the patients revealed alteration in the distribution and thickness of the elastic fi bers, which can be interpreted as a histological improvement, while 60% showed an increase in collagen density. We observed an increase in collagen density, from 51.2% to 57.4%, (p=0.004). At the end of the 12-week follow-up period, this density decreased to 54.7% (p=0.050). There was an increase in the density of elastic fibers, from 26.5% to 31.3%, (p=0.02), which had dropped to 27.5% at the end of the 12- week follow-up period. CONCLUSIONS: The study confirmed the role of oral isotretinoin in remodeling the extracellular matrix against photoaging, as well as its durability after 12 weeks, especially when we consider collagen fibers.engSociedade Brasileira de DermatologiaOral isotretinoin in photoaging: objective histological evidence of efficacy and durabilityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIsotretinoinRetinoidsSkin aginginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34726/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Bravo_Bruna_etal_INI_2015.pdfve_Bravo_Bruna_etal_INI_2015.pdfapplication/pdf217387https://www.arca.fiocruz.br/bitstream/icict/34726/2/ve_Bravo_Bruna_etal_INI_2015.pdf359a52985b36e09323523fb1a567449cMD52TEXTve_Bravo_Bruna_etal_INI_2015.pdf.txtve_Bravo_Bruna_etal_INI_2015.pdf.txtExtracted texttext/plain29375https://www.arca.fiocruz.br/bitstream/icict/34726/3/ve_Bravo_Bruna_etal_INI_2015.pdf.txt7e5a0b6911181b948186d9773b0e6b58MD53icict/347262019-08-13 02:02:31.966oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-08-13T05:02:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
title Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
spellingShingle Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
Bravo, Bruna Souza Felix
Isotretinoin
Retinoids
Skin aging
title_short Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
title_full Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
title_fullStr Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
title_full_unstemmed Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
title_sort Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
author Bravo, Bruna Souza Felix
author_facet Bravo, Bruna Souza Felix
Azulay, David Rubem
Luiz, Ronir Raggio
Mandarim-De-Lacerda, Carlos Alberto
Cuzzi, Tullia
Manela-Azulay, Mônica
author_role author
author2 Azulay, David Rubem
Luiz, Ronir Raggio
Mandarim-De-Lacerda, Carlos Alberto
Cuzzi, Tullia
Manela-Azulay, Mônica
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bravo, Bruna Souza Felix
Azulay, David Rubem
Luiz, Ronir Raggio
Mandarim-De-Lacerda, Carlos Alberto
Cuzzi, Tullia
Manela-Azulay, Mônica
dc.subject.en.pt_BR.fl_str_mv Isotretinoin
Retinoids
Skin aging
topic Isotretinoin
Retinoids
Skin aging
description Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-12T13:41:53Z
dc.date.available.fl_str_mv 2019-08-12T13:41:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34726
dc.identifier.issn.pt_BR.fl_str_mv 0365-0596
dc.identifier.doi.none.fl_str_mv 10.1590/abd1806-4841.20153703
identifier_str_mv BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015.
0365-0596
10.1590/abd1806-4841.20153703
url https://www.arca.fiocruz.br/handle/icict/34726
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
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