Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34726 |
Resumo: | Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Bravo, Bruna Souza FelixAzulay, David RubemLuiz, Ronir RaggioMandarim-De-Lacerda, Carlos AlbertoCuzzi, TulliaManela-Azulay, Mônica2019-08-12T13:41:53Z2019-08-12T13:41:53Z2015BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015.0365-0596https://www.arca.fiocruz.br/handle/icict/3472610.1590/abd1806-4841.20153703Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Santa Casa de Misericórdia do Rio de Janeiro. Instituto de Dermatologia Professor Rubem David Azulay. Rio de Janeiro, RJ, Brasil / Hospital Federal da Lagoa. Rio de Janeiro, RJ, Brasil.Santa Casa de Misericórdia do Rio de Janeiro. Instituto de Dermatologia Professor Rubem David Azulay. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.BACKGROUND: The off-label use of oral isotretinoin in photoaging is a therapeutic tool that has been used by dermatologists. There are few studies to corroborate its effectiveness and durability. OBJECTIVES: To assess, both clinically and histologically, the changes caused by the use of oral isotretinoin in skin photoaging as well as the duration of the effects. METHODS: 20 female patients, aged 45-50 years, with phototypes II-VI, none of whom had experienced menopause, were treated with 20mg oral isotretinoin, 3 days a week, for 12 weeks. They underwent clinical analysis and skin biopsies in the pre-auricular region, while histologic cuts enabled assessment of the solar elastosis level and morphologic analysis. RESULTS: Clinically, patients, as well as the researching and the assessor physicians, noticed improvement in skin quality. One patient presented severe solar elastosis, 11 manifested the moderate form, while 8 presented the discreet type. According to histological analysis, 65% of the patients revealed alteration in the distribution and thickness of the elastic fi bers, which can be interpreted as a histological improvement, while 60% showed an increase in collagen density. We observed an increase in collagen density, from 51.2% to 57.4%, (p=0.004). At the end of the 12-week follow-up period, this density decreased to 54.7% (p=0.050). There was an increase in the density of elastic fibers, from 26.5% to 31.3%, (p=0.02), which had dropped to 27.5% at the end of the 12- week follow-up period. CONCLUSIONS: The study confirmed the role of oral isotretinoin in remodeling the extracellular matrix against photoaging, as well as its durability after 12 weeks, especially when we consider collagen fibers.engSociedade Brasileira de DermatologiaOral isotretinoin in photoaging: objective histological evidence of efficacy and durabilityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIsotretinoinRetinoidsSkin aginginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34726/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Bravo_Bruna_etal_INI_2015.pdfve_Bravo_Bruna_etal_INI_2015.pdfapplication/pdf217387https://www.arca.fiocruz.br/bitstream/icict/34726/2/ve_Bravo_Bruna_etal_INI_2015.pdf359a52985b36e09323523fb1a567449cMD52TEXTve_Bravo_Bruna_etal_INI_2015.pdf.txtve_Bravo_Bruna_etal_INI_2015.pdf.txtExtracted texttext/plain29375https://www.arca.fiocruz.br/bitstream/icict/34726/3/ve_Bravo_Bruna_etal_INI_2015.pdf.txt7e5a0b6911181b948186d9773b0e6b58MD53icict/347262019-08-13 02:02:31.966oai:www.arca.fiocruz.br:icict/34726Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-08-13T05:02:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
title |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
spellingShingle |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability Bravo, Bruna Souza Felix Isotretinoin Retinoids Skin aging |
title_short |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
title_full |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
title_fullStr |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
title_full_unstemmed |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
title_sort |
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability |
author |
Bravo, Bruna Souza Felix |
author_facet |
Bravo, Bruna Souza Felix Azulay, David Rubem Luiz, Ronir Raggio Mandarim-De-Lacerda, Carlos Alberto Cuzzi, Tullia Manela-Azulay, Mônica |
author_role |
author |
author2 |
Azulay, David Rubem Luiz, Ronir Raggio Mandarim-De-Lacerda, Carlos Alberto Cuzzi, Tullia Manela-Azulay, Mônica |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Bravo, Bruna Souza Felix Azulay, David Rubem Luiz, Ronir Raggio Mandarim-De-Lacerda, Carlos Alberto Cuzzi, Tullia Manela-Azulay, Mônica |
dc.subject.en.pt_BR.fl_str_mv |
Isotretinoin Retinoids Skin aging |
topic |
Isotretinoin Retinoids Skin aging |
description |
Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2019-08-12T13:41:53Z |
dc.date.available.fl_str_mv |
2019-08-12T13:41:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/34726 |
dc.identifier.issn.pt_BR.fl_str_mv |
0365-0596 |
dc.identifier.doi.none.fl_str_mv |
10.1590/abd1806-4841.20153703 |
identifier_str_mv |
BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015. 0365-0596 10.1590/abd1806-4841.20153703 |
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https://www.arca.fiocruz.br/handle/icict/34726 |
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eng |
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Sociedade Brasileira de Dermatologia |
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Sociedade Brasileira de Dermatologia |
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