MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25947 |
Resumo: | National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil). |
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Valverde, Ludmila de FaroFreitas, Raíza Dias dePereira, Thiago de A.Resende, Marina F. deAgra, Ivan Marcelo GonçalvesSantos, Jean Nunes dosReis, Mitermayer Galvão dosSales, Caroline Brandi SchlaepferRocha, Clarissa Araújo Gurgel2018-04-19T13:34:05Z2018-04-19T13:34:05Z2018VALVERDE, L. F. et al. MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 26, n. 2, p. 120-125, 2018.1541-2016https://www.arca.fiocruz.br/handle/icict/2594710.1097/PAI.0000000000000397National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFederal University of Minas Gerais. School of Medicine of the Minas Gerais. Belo Horizonte, MG, BrasilAC Camargo Cancer Center. São Paulo, SP, BrasilAristides Maltez Hospital. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilThe present study sought to evaluate and compare the immunoexpression of proteins minichromosome maintenance (MCM) 3 and Ki-67 in oral squamous cell carcinoma (OSCC) to assess the potential of these proteins as markers of cellular proliferation. Twenty-eight cases of OSCC, 9 of tumor-free resection margins (TM), and 4 of non-neoplastic oral mucosa (NNM) were subjected to immunohistochemistry to detect the expression of proteins MCM3 and Ki-67. All OSCCs demonstrated positivity for both proteins. In these tumors, greater MCM3 immunoreactivity was observed in comparison with Ki-67, whereas TMs and NNMs exhibited greater Ki-67 expression compared with MCM3. The immunoexpression of Ki-67 seemed to be influenced by the inflammatory process, particularly in TM and NNM. Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors.engLippincott, Williams & WilkinsCarcinoma de células escamosasProliferação celularImunohistoquímicaSquamous cell carcinomaCellular proliferationImmunohistochemistryMCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25947/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALValverde LF MCM3; a nov4el.pdfValverde LF MCM3; a nov4el.pdfapplication/pdf354265https://www.arca.fiocruz.br/bitstream/icict/25947/2/Valverde%20LF%20MCM3%3b%20a%20nov4el.pdfd069ffa35d6fa2c65139d0a14da68320MD52TEXTValverde LF MCM3; a nov4el.pdf.txtValverde LF MCM3; a nov4el.pdf.txtExtracted texttext/plain31132https://www.arca.fiocruz.br/bitstream/icict/25947/3/Valverde%20LF%20MCM3%3b%20a%20nov4el.pdf.txt39f2cfdf6d071f8450d4bd1ecffbd11dMD53icict/259472023-03-15 14:33:54.228oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| title |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| spellingShingle |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma Valverde, Ludmila de Faro Carcinoma de células escamosas Proliferação celular Imunohistoquímica Squamous cell carcinoma Cellular proliferation Immunohistochemistry |
| title_short |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| title_full |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| title_fullStr |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| title_full_unstemmed |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| title_sort |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma |
| author |
Valverde, Ludmila de Faro |
| author_facet |
Valverde, Ludmila de Faro Freitas, Raíza Dias de Pereira, Thiago de A. Resende, Marina F. de Agra, Ivan Marcelo Gonçalves Santos, Jean Nunes dos Reis, Mitermayer Galvão dos Sales, Caroline Brandi Schlaepfer Rocha, Clarissa Araújo Gurgel |
| author_role |
author |
| author2 |
Freitas, Raíza Dias de Pereira, Thiago de A. Resende, Marina F. de Agra, Ivan Marcelo Gonçalves Santos, Jean Nunes dos Reis, Mitermayer Galvão dos Sales, Caroline Brandi Schlaepfer Rocha, Clarissa Araújo Gurgel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Valverde, Ludmila de Faro Freitas, Raíza Dias de Pereira, Thiago de A. Resende, Marina F. de Agra, Ivan Marcelo Gonçalves Santos, Jean Nunes dos Reis, Mitermayer Galvão dos Sales, Caroline Brandi Schlaepfer Rocha, Clarissa Araújo Gurgel |
| dc.subject.other.pt_BR.fl_str_mv |
Carcinoma de células escamosas Proliferação celular Imunohistoquímica |
| topic |
Carcinoma de células escamosas Proliferação celular Imunohistoquímica Squamous cell carcinoma Cellular proliferation Immunohistochemistry |
| dc.subject.en.pt_BR.fl_str_mv |
Squamous cell carcinoma Cellular proliferation Immunohistochemistry |
| description |
National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil). |
| publishDate |
2018 |
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2018-04-19T13:34:05Z |
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2018-04-19T13:34:05Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
VALVERDE, L. F. et al. MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 26, n. 2, p. 120-125, 2018. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/25947 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1541-2016 |
| dc.identifier.doi.none.fl_str_mv |
10.1097/PAI.0000000000000397 |
| identifier_str_mv |
VALVERDE, L. F. et al. MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 26, n. 2, p. 120-125, 2018. 1541-2016 10.1097/PAI.0000000000000397 |
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eng |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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