Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18805 |
Resumo: | Wellcome Trust, the HCPC Latin America Excellence Centre Programme (072405/Z/03/Z), and the Brazilian agency Conselho Nacional de Desenvolvimento Científico e TecnológicoeCNPq |
| id |
CRUZ_3bb62c91bf8149f0fbd5997bcfcbe509 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/18805 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Costa, Ryan Dos SantosFigueiredo, Camila AlexandrinaBarreto, Maurício LimaNeves, Neuza Maria AlcântaraRodrigues, Laura CunhaCruz, Alvaro AVergara, CandelariaRafaels, NicholasFoster, CassandraPotee, JosephCampbell, MonicaMathias, Rasika ABarnes, Kathleen C2017-05-10T18:42:15Z2017-05-10T18:42:15Z2017COSTA, R. dos S. et al. Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population. Annals of Allergy, Asthma and Immunology, p.1-6, 2017.1081-1206https://www.arca.fiocruz.br/handle/icict/1880510.1016/j.anai.2017.01.028Wellcome Trust, the HCPC Latin America Excellence Centre Programme (072405/Z/03/Z), and the Brazilian agency Conselho Nacional de Desenvolvimento Científico e TecnológicoeCNPqJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland / Federal University of Bahia. Health Science Institute. Salvador, BA, BrazilFederal University of Bahia. Health Science Institute. Salvador, BA, BrazilFederal University of Bahia. Public Health Institute. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, BrazilFederal University of Bahia. Health Science Institute. Salvador, BA, BrazilLondon School of Hygiene and Tropical Medicine. London, EnglandFederal University of Bahia. Center of Excellence in Asthma. Salvador, BA, BrazilJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, MarylandJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, MarylandJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, MarylandJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, MarylandJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, MarylandJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, MarylandJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, Maryland / University of Colorado Denver. Department of Medicine. Aurora, ColoradoAllergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. The role of TGF- β 1 single-nucleotide polymorphisms (SNPs) in allergic disease remains inconclusive. Objective: To evaluate the effects of genetic variations in the TGF-b1 on allergy and helminths infections in children. Methods: We tested for association among 4 TGF-b1 SNPs and allergic asthma, specific IgE, skin prick test result, and IL-10 production in 1,335 Brazilians. In addition, we analyzed the association with markers of helminth infection (parasite burden, anti-Ascaris IgE, and worm specific IgG4). The polymorphisms were genotyped using Taq Man probes. Results: We found an association between rs1800470 (C allele) and atopic wheezing (odds ratio [OR], 0.60; 95% confidence interval [CI], 0.37e0.95) and markers of allergy (OR, 0.41; 95% CI, 0.22e0.79). In contrast, a positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85; P ¼ .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001). This haplotype was also associated with increased IL-10 production (b ¼ 50.7; P < .001). Conclusion: Individuals with TGF-b1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. These studies suggest that immune modulation of allergic disease results not only from environmental factors but also from genetic susceptibility and IL-10 productionengElsevierAsmaPolimorfismoPopulaçãoHelmintosInfecções por HelmintosVariação genéticaAlergiaAsthmaPolymorphismsPopulationhelminthHelminth InfectionGenetic variationsAllergicAsmaPolimorfismoPopulaçãoHelmintosInfecções por HelmintosVariação genéticaAlergiaEffect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18805/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta RS Effect of polymorphisms....pdfCosta RS Effect of polymorphisms....pdfapplication/pdf397845https://www.arca.fiocruz.br/bitstream/icict/18805/2/Costa%20RS%20Effect%20of%20polymorphisms....pdf0d9be39ccd3aab2517c962ca6a35d75dMD52TEXTCosta RS Effect of polymorphisms....pdf.txtCosta RS Effect of polymorphisms....pdf.txtExtracted texttext/plain42030https://www.arca.fiocruz.br/bitstream/icict/18805/3/Costa%20RS%20Effect%20of%20polymorphisms....pdf.txt262eda31e15c3eaf172f9c3cd2af3870MD53icict/188052023-03-15 14:33:28.172oai:www.arca.fiocruz.br:icict/18805Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:28Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| title |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| spellingShingle |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population Costa, Ryan Dos Santos Asma Polimorfismo População Helmintos Infecções por Helmintos Variação genética Alergia Asthma Polymorphisms Population helminth Helminth Infection Genetic variations Allergic Asma Polimorfismo População Helmintos Infecções por Helmintos Variação genética Alergia |
| title_short |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| title_full |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| title_fullStr |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| title_full_unstemmed |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| title_sort |
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population |
| author |
Costa, Ryan Dos Santos |
| author_facet |
Costa, Ryan Dos Santos Figueiredo, Camila Alexandrina Barreto, Maurício Lima Neves, Neuza Maria Alcântara Rodrigues, Laura Cunha Cruz, Alvaro A Vergara, Candelaria Rafaels, Nicholas Foster, Cassandra Potee, Joseph Campbell, Monica Mathias, Rasika A Barnes, Kathleen C |
| author_role |
author |
| author2 |
Figueiredo, Camila Alexandrina Barreto, Maurício Lima Neves, Neuza Maria Alcântara Rodrigues, Laura Cunha Cruz, Alvaro A Vergara, Candelaria Rafaels, Nicholas Foster, Cassandra Potee, Joseph Campbell, Monica Mathias, Rasika A Barnes, Kathleen C |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Ryan Dos Santos Figueiredo, Camila Alexandrina Barreto, Maurício Lima Neves, Neuza Maria Alcântara Rodrigues, Laura Cunha Cruz, Alvaro A Vergara, Candelaria Rafaels, Nicholas Foster, Cassandra Potee, Joseph Campbell, Monica Mathias, Rasika A Barnes, Kathleen C |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Polimorfismo População Helmintos Infecções por Helmintos Variação genética Alergia |
| topic |
Asma Polimorfismo População Helmintos Infecções por Helmintos Variação genética Alergia Asthma Polymorphisms Population helminth Helminth Infection Genetic variations Allergic Asma Polimorfismo População Helmintos Infecções por Helmintos Variação genética Alergia |
| dc.subject.en.pt_BR.fl_str_mv |
Asthma Polymorphisms Population helminth Helminth Infection Genetic variations Allergic |
| dc.subject.decs.pt_BR.fl_str_mv |
Asma Polimorfismo População Helmintos Infecções por Helmintos Variação genética Alergia |
| description |
Wellcome Trust, the HCPC Latin America Excellence Centre Programme (072405/Z/03/Z), and the Brazilian agency Conselho Nacional de Desenvolvimento Científico e TecnológicoeCNPq |
| publishDate |
2017 |
| dc.date.accessioned.fl_str_mv |
2017-05-10T18:42:15Z |
| dc.date.available.fl_str_mv |
2017-05-10T18:42:15Z |
| dc.date.issued.fl_str_mv |
2017 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
COSTA, R. dos S. et al. Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population. Annals of Allergy, Asthma and Immunology, p.1-6, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18805 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1081-1206 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.anai.2017.01.028 |
| identifier_str_mv |
COSTA, R. dos S. et al. Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population. Annals of Allergy, Asthma and Immunology, p.1-6, 2017. 1081-1206 10.1016/j.anai.2017.01.028 |
| url |
https://www.arca.fiocruz.br/handle/icict/18805 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/18805/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/18805/2/Costa%20RS%20Effect%20of%20polymorphisms....pdf https://www.arca.fiocruz.br/bitstream/icict/18805/3/Costa%20RS%20Effect%20of%20polymorphisms....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 0d9be39ccd3aab2517c962ca6a35d75d 262eda31e15c3eaf172f9c3cd2af3870 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009153445068800 |