Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25976 |
Resumo: | Rocha, Clarissa Araujo Gurgel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Ismerim, Adna BarrosFerreira, Stephany VascoLessa, Anne Maria GuimarãesPereira Júnior, Aderbal SousaRocha, Clarissa Araújo GurgelCamillo, Claudia Malheiros CoutinhoSoares, Fernando AugustoVilas-Bôas, Deise SouzaVidal, Manuela Torres AndionSantos, Jean Nunes dos2018-04-20T13:10:12Z2018-04-20T13:10:12Z2016ISMERIM, A. B. et al. Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors. Applied Immunohistochemistry and Molecular Morphology, v. 24, p. 422–426, 2016.1541-2016https://www.arca.fiocruz.br/handle/icict/25976Rocha, Clarissa Araujo Gurgel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.CNPq and FAPESB for financial support and scholarshipsFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, BrasilA.C. Camargo Center Cancer, São Paulo, SP, BrasilA.C. Camargo Center Cancer, São Paulo, SP, BrasilFederal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, BrasilInsulin-like growth factor II mRNA-binding protein 3 (IMP3) is strongly expressed in malignant tumors and has been associated with their aggressive behavior. The aim of this study was to evaluate the presence of IMP3 in a series of salivary gland tumors. The sample consisted of 9 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 13 mucoepidermoid carcinomas (MEC) that were investigated by immunohistochemical technique. All cases of PA and MEC were positive for IMP3 particularly in the cytoplasm. PA showed 4 cases as high expression and 6 as low expression. MEC showed 10 cases as low expression and 3 as high expression. For ACC, 4 cases were high expression, whereas 6 cases were low expression. No significant difference was observed between tumors (P>0.05, Fisher’s test) when both scores of IMP3 were compared. This study showed that MEC seems to be more sensitive to IMP3 than ACC and provided an insight into this protein in salivary gland tumors. Furthermore, although IMP3 is not a specific diagnostic marker to distinguish the tumors studied, it seems to mediate cell adhesion and migration in these tumors. Further studies should be performed to better understand the IMP3 biology in salivary gland tumors.engLippincott, Williams & WilkinsFator de crescimento semelhante a insulina IITumor malignoCâncer salivarImuno-histoquímicaInsulin-like growth factor IIMalignant tumorSalivary cancerImmunohistochemistryInsulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25976/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALIsmerim AB Insulin-like....pdfIsmerim AB Insulin-like....pdfapplication/pdf324349https://www.arca.fiocruz.br/bitstream/icict/25976/2/Ismerim%20AB%20Insulin-like....pdf0e7d4fd31ab9308c6d6984f11f980446MD52TEXTIsmerim AB Insulin-like....pdf.txtIsmerim AB Insulin-like....pdf.txtExtracted texttext/plain23494https://www.arca.fiocruz.br/bitstream/icict/25976/3/Ismerim%20AB%20Insulin-like....pdf.txt9ec01e7b65662e8e6531e4b1b429cab7MD53icict/259762023-03-15 14:33:54.305oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| title |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| spellingShingle |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors Ismerim, Adna Barros Fator de crescimento semelhante a insulina II Tumor maligno Câncer salivar Imuno-histoquímica Insulin-like growth factor II Malignant tumor Salivary cancer Immunohistochemistry |
| title_short |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| title_full |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| title_fullStr |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| title_full_unstemmed |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| title_sort |
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors |
| author |
Ismerim, Adna Barros |
| author_facet |
Ismerim, Adna Barros Ferreira, Stephany Vasco Lessa, Anne Maria Guimarães Pereira Júnior, Aderbal Sousa Rocha, Clarissa Araújo Gurgel Camillo, Claudia Malheiros Coutinho Soares, Fernando Augusto Vilas-Bôas, Deise Souza Vidal, Manuela Torres Andion Santos, Jean Nunes dos |
| author_role |
author |
| author2 |
Ferreira, Stephany Vasco Lessa, Anne Maria Guimarães Pereira Júnior, Aderbal Sousa Rocha, Clarissa Araújo Gurgel Camillo, Claudia Malheiros Coutinho Soares, Fernando Augusto Vilas-Bôas, Deise Souza Vidal, Manuela Torres Andion Santos, Jean Nunes dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ismerim, Adna Barros Ferreira, Stephany Vasco Lessa, Anne Maria Guimarães Pereira Júnior, Aderbal Sousa Rocha, Clarissa Araújo Gurgel Camillo, Claudia Malheiros Coutinho Soares, Fernando Augusto Vilas-Bôas, Deise Souza Vidal, Manuela Torres Andion Santos, Jean Nunes dos |
| dc.subject.other.pt_BR.fl_str_mv |
Fator de crescimento semelhante a insulina II Tumor maligno Câncer salivar Imuno-histoquímica |
| topic |
Fator de crescimento semelhante a insulina II Tumor maligno Câncer salivar Imuno-histoquímica Insulin-like growth factor II Malignant tumor Salivary cancer Immunohistochemistry |
| dc.subject.en.pt_BR.fl_str_mv |
Insulin-like growth factor II Malignant tumor Salivary cancer Immunohistochemistry |
| description |
Rocha, Clarissa Araujo Gurgel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2016 |
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2016 |
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2018-04-20T13:10:12Z |
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2018-04-20T13:10:12Z |
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info:eu-repo/semantics/article |
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publishedVersion |
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ISMERIM, A. B. et al. Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors. Applied Immunohistochemistry and Molecular Morphology, v. 24, p. 422–426, 2016. |
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https://www.arca.fiocruz.br/handle/icict/25976 |
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1541-2016 |
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ISMERIM, A. B. et al. Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors. Applied Immunohistochemistry and Molecular Morphology, v. 24, p. 422–426, 2016. 1541-2016 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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