High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection

Detalhes bibliográficos
Autor(a) principal: Lemos, Denise da Silveira
Data de Publicação: 2006
Outros Autores: Carvalho, Andréa Teixeira, Martins Filho, Olindo Assis, Oliveira, Lúcia Fraga Alves, Oliveira, Rodrigo Corrêa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: org/10.1590/S0074-02762006000900056
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6583
Resumo: CPqRR/Fiocruz, CNPq, National Institutes of Health (PA- 98-078)
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spelling Lemos, Denise da SilveiraCarvalho, Andréa TeixeiraMartins Filho, Olindo AssisOliveira, Lúcia Fraga AlvesOliveira, Rodrigo Corrêa de2013-06-12T18:33:20Z2013-06-12T18:33:20Z2006SILVEIRA-LEMOS, Denise et al. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz . 2006, vol.101, suppl.1, pp. 345-3510074-0276https://www.arca.fiocruz.br/handle/icict/6583org/10.1590/S0074-02762006000900056CPqRR/Fiocruz, CNPq, National Institutes of Health (PA- 98-078)Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, BrasilUniversidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilHere in we have focused attention on major phenotypic features of peripheral blood eosinophils from chronic Schistosoma mansoni-infected patients. For this purpose, detailed immunophenotypic profiles of a range of cell surface markers were performed, including activation markers (CD23/CD69/CD25/HLA-DR), co-stimulatory mol-ecules (CD28/CD80/CD86), chemokine receptors (CXCR1/CXCR2/CCR3/CCR5) besides L-selectin-CD62L and adhesion molecules (CD18/CD54). Our major findings pointed out increased frequency of CD23 + -cells, besides decreased percentages of CD69 + -eosinophils, suggesting a chronic activation status with low frequency of early activated eosinophils in chronic S. mansoni-infected patients (INT) in comparison to non-infected individuals (NI). Moreover, a dichotomic expression of beta-chemokine receptors was observed during human schistosomiasis mansoni with higher CCR5 and lower levels of CCR3 observed between groups. Enhanced expression of co-stimulatory receptors (CD28/CD86) and adhesion molecules (CD54/CD18), besides striking lower frequency of L-selectin + were reported for eosinophils from INT group as compared to NI. Interestingly, the frequency of CD62L+ -eosinophils and a range of cell activation related molecules pointed out an opposite pattern of association in NI and INT, where only INT patients that display lower frequency of CD62L + -eosinophils (first CD62L tertile) kept the unusual rela-tionship between the expression of L-selectin and the CD23 activation marker. These findings suggest that distinct dynamic of activation markers expressed by eosinophils may occur during chronic S. mansoni infection.engHigh expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSchistosomiasisEosinophilsActivation markersL-selectininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL114.pdf114.pdfapplication/pdf600626https://www.arca.fiocruz.br/bitstream/icict/6583/1/114.pdf1faff021f7b6caffcdef3a35bbcc4952MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6583/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT114.pdf.txt114.pdf.txtExtracted texttext/plain33351https://www.arca.fiocruz.br/bitstream/icict/6583/5/114.pdf.txtdeaa9c6d17193177d75854a7214eeab4MD55THUMBNAIL114.pdf.jpg114.pdf.jpgGenerated Thumbnailimage/jpeg2305https://www.arca.fiocruz.br/bitstream/icict/6583/4/114.pdf.jpg02d4b88759a6aa6e0559623c79ef2892MD54icict/65832018-04-06 08:50:36.763oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:50:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
title High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
spellingShingle High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
Lemos, Denise da Silveira
Schistosomiasis
Eosinophils
Activation markers
L-selectin
title_short High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
title_full High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
title_fullStr High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
title_full_unstemmed High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
title_sort High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
author Lemos, Denise da Silveira
author_facet Lemos, Denise da Silveira
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Oliveira, Lúcia Fraga Alves
Oliveira, Rodrigo Corrêa de
author_role author
author2 Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Oliveira, Lúcia Fraga Alves
Oliveira, Rodrigo Corrêa de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lemos, Denise da Silveira
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Oliveira, Lúcia Fraga Alves
Oliveira, Rodrigo Corrêa de
dc.subject.en.pt_BR.fl_str_mv Schistosomiasis
Eosinophils
Activation markers
L-selectin
topic Schistosomiasis
Eosinophils
Activation markers
L-selectin
description CPqRR/Fiocruz, CNPq, National Institutes of Health (PA- 98-078)
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-06-12T18:33:20Z
dc.date.available.fl_str_mv 2013-06-12T18:33:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SILVEIRA-LEMOS, Denise et al. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz . 2006, vol.101, suppl.1, pp. 345-351
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6583
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv org/10.1590/S0074-02762006000900056
identifier_str_mv SILVEIRA-LEMOS, Denise et al. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz . 2006, vol.101, suppl.1, pp. 345-351
0074-0276
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