Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress

Detalhes bibliográficos
Autor(a) principal: Monte Neto, Rubens Lima do
Data de Publicação: 2022
Outros Autores: Moreira, Paulo Otávio Lourenço, Sousa, Alessandra Mara de, Garcia, Miguel Antonio do Nascimento, Maran, Suellen Rodrigues, Moretti, Nilmar Silvio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56020
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisas em Biotecnologia Aplicada ao Estudo de Patógenos. Belo Horizonte, MG, Brasil.
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spelling Monte Neto, Rubens Lima doMoreira, Paulo Otávio LourençoSousa, Alessandra Mara deGarcia, Miguel Antonio do NascimentoMaran, Suellen RodriguesMoretti, Nilmar Silvio2022-12-16T17:00:27Z2022-12-16T17:00:27Z2022MONTE NETO, Rubens Lima do et al. Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, p. 1-11, 2022.0074-0276https://www.arca.fiocruz.br/handle/icict/5602010.1590/0074-02760220403engFiocruz/IOCAntileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progressinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisas em Biotecnologia Aplicada ao Estudo de Patógenos. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisas em Biotecnologia Aplicada ao Estudo de Patógenos. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisas em Biotecnologia Aplicada ao Estudo de Patógenos. Belo Horizonte, MG, Brasil.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Biologia Molecular de Patógenos. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Biologia Molecular de Patógenos. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Biologia Molecular de Patógenos. São Paulo, SP, Brasil.Despite the increasing number of manuscripts describing potential alternative antileishmanial compounds, little is advancing on translating these knowledges to new products to treat leishmaniasis. This is in part due to the lack of standardisations during pre-clinical drug discovery stage and also depends on the alignment of goals among universities/research centers, government and pharmaceutical industry. Inspired or not by drug repurposing, metal-based antileishmanial drugs represent a class that deserves more attention on its use for leishmaniasis chemotherapy. Together with new chemical entities, progresses have been made on the knowledge of parasite-specific drug targets specially after using CRISPR/Cas system for functional studies. In this regard, Leishmania parasites undergoe post-translational modification as key regulators in several cellular processes, which represents an entire new field for drug target elucidation, once this is poorly explored. This perspective review describes the advances on antileishmanial metallodrugs and the elucidation of drug targets based on post-translational modifications, highlighting the limitations on the drug discovery/development process and suggesting standardisations focused on products addressed to who need it most.LeishmaniaMetallodrugsAntileishmanialTarget elucidationPost-translational modificationsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56020/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAntileishmanial metallodrugs and the elucidation of new drug.pdfAntileishmanial metallodrugs and the elucidation of new 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dc.title.en_US.fl_str_mv Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
title Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
spellingShingle Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
Monte Neto, Rubens Lima do
Leishmania
Metallodrugs
Antileishmanial
Target elucidation
Post-translational modifications
title_short Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
title_full Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
title_fullStr Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
title_full_unstemmed Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
title_sort Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
author Monte Neto, Rubens Lima do
author_facet Monte Neto, Rubens Lima do
Moreira, Paulo Otávio Lourenço
Sousa, Alessandra Mara de
Garcia, Miguel Antonio do Nascimento
Maran, Suellen Rodrigues
Moretti, Nilmar Silvio
author_role author
author2 Moreira, Paulo Otávio Lourenço
Sousa, Alessandra Mara de
Garcia, Miguel Antonio do Nascimento
Maran, Suellen Rodrigues
Moretti, Nilmar Silvio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Monte Neto, Rubens Lima do
Moreira, Paulo Otávio Lourenço
Sousa, Alessandra Mara de
Garcia, Miguel Antonio do Nascimento
Maran, Suellen Rodrigues
Moretti, Nilmar Silvio
dc.subject.en.en_US.fl_str_mv Leishmania
Metallodrugs
Antileishmanial
Target elucidation
Post-translational modifications
topic Leishmania
Metallodrugs
Antileishmanial
Target elucidation
Post-translational modifications
description Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisas em Biotecnologia Aplicada ao Estudo de Patógenos. Belo Horizonte, MG, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-16T17:00:27Z
dc.date.available.fl_str_mv 2022-12-16T17:00:27Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MONTE NETO, Rubens Lima do et al. Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, p. 1-11, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56020
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760220403
identifier_str_mv MONTE NETO, Rubens Lima do et al. Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, p. 1-11, 2022.
0074-0276
10.1590/0074-02760220403
url https://www.arca.fiocruz.br/handle/icict/56020
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56020/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56020/2/Antileishmanial%20metallodrugs%20and%20the%20elucidation%20of%20new%20drug.pdf
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