Ruthenium(II) complexes with hydroxypyridinecarboxylates : screening potential metallodrugs against Mycobacterium tuberculosis.

• Autor(a) principal: Barbosa, Marília Imaculada Frazão
• Data de Publicação: 2015
• Outros Autores: Correa, Rodrigo de Souza, Pozzi, Lucas Vinícius dos Santos, Pavan, Fernando Rogério, Leite, Clarice Queico Fujimura, Ellena, Javier Alcides, Machado, Sérgio de Paula, Poelhsitz, Gustavo Von, Batista, Alzir Azevedo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/7034; https://doi.org/10.1016/j.poly.2014.08.057
• topic: Mycobacterium tuberculosis; Ruthenium(II) complexes; Cytotoxicity; Metallodrugs; Hydroxypyridinecarboxylates

Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index.