Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease

Detalhes bibliográficos
Autor(a) principal: Camara, Edmundo José Nassri
Data de Publicação: 2019
Outros Autores: Mendonca, Vitor Rosa Ramos, Souza, Ligia C. L., Carvalho, Juliana S., Lessa, Rudá Alves, Gatto, Ramon, Barreto, Luan Oliveira, Chiacchio, Giulianna, Amarante, Eduardo, Cunha, Monaliza, Silva, Luis S. Alves, Guimarães, Benelson A. C., Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31267
Resumo: Conselho Nacional de Pesquisa e Tecnologia (CNPq), Brazil. VRRM and LCLS were supported by CNPq.
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spelling Camara, Edmundo José NassriMendonca, Vitor Rosa RamosSouza, Ligia C. L.Carvalho, Juliana S.Lessa, Rudá AlvesGatto, RamonBarreto, Luan OliveiraChiacchio, GiuliannaAmarante, EduardoCunha, MonalizaSilva, Luis S. AlvesGuimarães, Benelson A. C.Barral Netto, Manoel2019-01-23T17:54:22Z2019-01-23T17:54:22Z2019CAMARA, E. J. N. et al. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease. International Journal of Infectious Diseases, v. 79, p. 123-130, 2019.1201-9712https://www.arca.fiocruz.br/handle/icict/3126710.1016/j.ijid.2018.11.369Conselho Nacional de Pesquisa e Tecnologia (CNPq), Brazil. VRRM and LCLS were supported by CNPq.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.Climecar. Clinica de Cardiologia. Itaberaba, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia. São Paulo, SP, Brasil.The immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear. Methodology and findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirtythree patients had been previously treated with benznidazole and 33 had never been treated. The treated group exhibited higher levels of IL-17 (median 142.45 1.22 pg/ml, P = 0.025), which was the only one significantly associated with Bz treatment, especially after adjusting for time of disease and NYHA class (P = 0.024; OR 1.006, 95% CI 1.001-1.010). Compared to untreated patients, the treated group exhibited higher median values of mitral annular E’ lateral (13.0 10.0 cm/s, P = 0.038), S’ infero-lateral (8.9 7.6 cm/s, P = 0.013), S’ septal (8.5 7.4 cm/s, P = 0.034), mean S’ (9.0 7.9 cm/s, P = 0.013) and tricuspid annular S’ (13.3 11.1 cm/s, P = 0.001) and lower values of E/E’ septal (7.2 9.5 cm/s, P = 0.049). After adjustment for time of disease and NYHA class, S’ infero-lateral (P = 0.031), mean S’ (P = 0.049) and S’ tricuspid (P = 0.024) persisted as significantly associated with treatment. Conclusion: The present findings suggest that the group of CCD patients treated with Bz displayed increased plasma levels of IL-17 and preserved myocardial function, reinforcing the idea that Bz treatment may be beneficial.engElsevierDoença de ChagasTratamento com benznidazolResposta imuneCitocinasEcocardiográficoDoppler tecidualChagas’ diseaseBenznidazol treatmentImmune responseCytokinesEchocardiographicTissue DopplerElevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31267/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCAMARA, E.J. 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dc.title.pt_BR.fl_str_mv Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
title Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
spellingShingle Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
Camara, Edmundo José Nassri
Doença de Chagas
Tratamento com benznidazol
Resposta imune
Citocinas
Ecocardiográfico
Doppler tecidual
Chagas’ disease
Benznidazol treatment
Immune response
Cytokines
Echocardiographic
Tissue Doppler
title_short Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
title_full Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
title_fullStr Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
title_full_unstemmed Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
title_sort Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
author Camara, Edmundo José Nassri
author_facet Camara, Edmundo José Nassri
Mendonca, Vitor Rosa Ramos
Souza, Ligia C. L.
Carvalho, Juliana S.
Lessa, Rudá Alves
Gatto, Ramon
Barreto, Luan Oliveira
Chiacchio, Giulianna
Amarante, Eduardo
Cunha, Monaliza
Silva, Luis S. Alves
Guimarães, Benelson A. C.
Barral Netto, Manoel
author_role author
author2 Mendonca, Vitor Rosa Ramos
Souza, Ligia C. L.
Carvalho, Juliana S.
Lessa, Rudá Alves
Gatto, Ramon
Barreto, Luan Oliveira
Chiacchio, Giulianna
Amarante, Eduardo
Cunha, Monaliza
Silva, Luis S. Alves
Guimarães, Benelson A. C.
Barral Netto, Manoel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Camara, Edmundo José Nassri
Mendonca, Vitor Rosa Ramos
Souza, Ligia C. L.
Carvalho, Juliana S.
Lessa, Rudá Alves
Gatto, Ramon
Barreto, Luan Oliveira
Chiacchio, Giulianna
Amarante, Eduardo
Cunha, Monaliza
Silva, Luis S. Alves
Guimarães, Benelson A. C.
Barral Netto, Manoel
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Tratamento com benznidazol
Resposta imune
Citocinas
Ecocardiográfico
Doppler tecidual
topic Doença de Chagas
Tratamento com benznidazol
Resposta imune
Citocinas
Ecocardiográfico
Doppler tecidual
Chagas’ disease
Benznidazol treatment
Immune response
Cytokines
Echocardiographic
Tissue Doppler
dc.subject.en.pt_BR.fl_str_mv Chagas’ disease
Benznidazol treatment
Immune response
Cytokines
Echocardiographic
Tissue Doppler
description Conselho Nacional de Pesquisa e Tecnologia (CNPq), Brazil. VRRM and LCLS were supported by CNPq.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-01-23T17:54:22Z
dc.date.available.fl_str_mv 2019-01-23T17:54:22Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMARA, E. J. N. et al. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease. International Journal of Infectious Diseases, v. 79, p. 123-130, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31267
dc.identifier.issn.pt_BR.fl_str_mv 1201-9712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2018.11.369
identifier_str_mv CAMARA, E. J. N. et al. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease. International Journal of Infectious Diseases, v. 79, p. 123-130, 2019.
1201-9712
10.1016/j.ijid.2018.11.369
url https://www.arca.fiocruz.br/handle/icict/31267
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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