IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Gimblet, Ciara
Data de Publicação: 2015
Outros Autores: Loesche, Michael A, Carvalho, Lucas Pedreira de, Carvalho Filho, Edgar Marcelino, Grice, Elizabeth A, Artis, David, Scott, Phillip
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20496
Resumo: Carvalho, Lucas Pedreira de; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Gimblet, CiaraLoesche, Michael ACarvalho, Lucas Pedreira deCarvalho Filho, Edgar MarcelinoGrice, Elizabeth AArtis, DavidScott, Phillip2017-08-02T17:23:58Z2017-08-02T17:23:58Z2015GIMBLET, C. et al. IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis. Plos One, v. 10, n. 8, p. e0134698, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/2049610.1371/journal.pone.0134698Carvalho, Lucas Pedreira de; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institutes of Health, RO1AI106842 (PS), AR060873 (EAG), Tropical Medicine Research Centers AI30639 (EMC), and T32AI753216 (CG)University of Pennsylvania. School of Veterinary Medicine. Department of Pathobiology. Philadelphia, PA, USAUniversity of Pennsylvania. Perelman School of Medicine. Department of Dermatology. Philadelphia, PA, USAUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia. Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversity of Pennsylvania. Perelman School of Medicine. Department of Dermatology. Philadelphia, PA, USAUniversity of Pennsylvania. Perelman School of Medicine. Department of Microbiology. Philadelphia, PA, USAUniversity of Pennsylvania. School of Veterinary Medicine. Department of Pathobiology. Philadelphia, PA, USACutaneous leishmaniasis is a disease characterized by ulcerating skin lesions, the resolution of which requires an effective, but regulated, immune response that limits parasite growth without causing permanent tissue damage. While mechanisms that control the parasites have been well studied, the factors regulating immunopathologic responses are less well understood. IL-22, a member of the IL-10 family of cytokines, can contribute to wound healing, but in other instances promotes pathology. Here we investigated the role of IL-22 during leishmania infection, and found that IL-22 limits leishmania-induced pathology when a certain threshold of damage is induced by a high dose of parasites. Il22-/- mice developed more severe disease than wild-type mice, with significantly more pathology at the site of infection, and in some cases permanent loss of tissue. The increased inflammation was not due to an increased parasite burden, but rather was associated with the loss of a wound healing phenotype in keratinocytes. Taken together, these studies demonstrate that during cutaneous leishmaniasis, IL-22 can play a previously unappreciated role in controlling leishmania-induced immunopathology.engPublic Library of ScienceLeishmaniose CutâneaInterleucinasCicatrização de feridasAnimaisPeleRatosLeishmaniasis, CutaneousInterleukinsWound HealingAnimalsSkinMiceIL-22 Protects against Tissue Damage during Cutaneous Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20496/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGimblet C Il-22 protects against....pdfGimblet C Il-22 protects 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dc.title.pt_BR.fl_str_mv IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
title IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
spellingShingle IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
Gimblet, Ciara
Leishmaniose Cutânea
Interleucinas
Cicatrização de feridas
Animais
Pele
Ratos
Leishmaniasis, Cutaneous
Interleukins
Wound Healing
Animals
Skin
Mice
title_short IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
title_full IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
title_fullStr IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
title_full_unstemmed IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
title_sort IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis
author Gimblet, Ciara
author_facet Gimblet, Ciara
Loesche, Michael A
Carvalho, Lucas Pedreira de
Carvalho Filho, Edgar Marcelino
Grice, Elizabeth A
Artis, David
Scott, Phillip
author_role author
author2 Loesche, Michael A
Carvalho, Lucas Pedreira de
Carvalho Filho, Edgar Marcelino
Grice, Elizabeth A
Artis, David
Scott, Phillip
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gimblet, Ciara
Loesche, Michael A
Carvalho, Lucas Pedreira de
Carvalho Filho, Edgar Marcelino
Grice, Elizabeth A
Artis, David
Scott, Phillip
dc.subject.other.pt_BR.fl_str_mv Leishmaniose Cutânea
Interleucinas
Cicatrização de feridas
Animais
Pele
Ratos
topic Leishmaniose Cutânea
Interleucinas
Cicatrização de feridas
Animais
Pele
Ratos
Leishmaniasis, Cutaneous
Interleukins
Wound Healing
Animals
Skin
Mice
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis, Cutaneous
Interleukins
Wound Healing
Animals
Skin
Mice
description Carvalho, Lucas Pedreira de; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-08-02T17:23:58Z
dc.date.available.fl_str_mv 2017-08-02T17:23:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GIMBLET, C. et al. IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis. Plos One, v. 10, n. 8, p. e0134698, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20496
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0134698
identifier_str_mv GIMBLET, C. et al. IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis. Plos One, v. 10, n. 8, p. e0134698, 2015.
1932-6203
10.1371/journal.pone.0134698
url https://www.arca.fiocruz.br/handle/icict/20496
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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