Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15270 |
Resumo: | Brazilian National Council of Research (CNPq 3065427/2007-5 and 484457/2007-1. Foundation of Research of Bahia (FAPESB; 1431040053063 and 9073/2007) |
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Vilas-Boas, WendellCerqueira, Bruno Antonio VelosoZanette, Angela Maria DiasReis, Mitermayer Galvão dosBarral Netto, ManoelGoncalves, Marilda de Souza2016-08-16T14:11:42Z2016-08-16T14:11:42Z2010VILAS-BOAS, W. et al. Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients. Annals of Hematology, v. 89, p. 877–882, 2010.0939-5555https://www.arca.fiocruz.br/handle/icict/1527010.1007/s00277-010-0954-9Brazilian National Council of Research (CNPq 3065427/2007-5 and 484457/2007-1. Foundation of Research of Bahia (FAPESB; 1431040053063 and 9073/2007)Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundacao de Hematologia e Hemoterapia da Bahia. Hemoba. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSickle cell anemia (SCA) is characterized by a marked endothelial dysfunction, owing to many factors. Arginine metabolism can be related to the inflammatory chronic state presented by patients, playing a key role in their clinical outcome and vascular endothelium. We investigated the serum arginase levels in 50 SCA patients (22 men and 28 women, mean age of 17 +/- 10.5 years) and 28 healthy controls. Serum arginase levels were associated with biochemical hemolysis markers and cytokines involved in Th17 response, as well as levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1). Arginase concentrations were higher in SCA patients, compared with controls (p = 0.005), and were significantly and positively associated with total bilirubin (p = 0.004), indirect bilirubin (p = 0.04), and aspartate aminotransferase (AST; p = 0.039) in the SCA patient group. Moreover, arginase was significantly and positively associated with transforming growth factor-beta (TGF-beta; p = 0.008) among SCA patients. sICAM-1 was significantly and positively associated to reticulocytes (p = 0.014) and AST (p = 0.04). sVCAM-1 was likewise associated with lactate dehydrogenase (p = 0.03). These data suggest a new insight into arginase metabolism, as we show here a shift in arginine catabolism, where TGF-beta may induces the arginase pathway instead of the nitric oxide pathway and a possible involvement of the vascular activation and the serum arginase in chronic hemolysis among SCA patients. Additional studies should be carried out in order to investigate the mechanisms by which TGF-beta participates in the metabolism of arginase in SCA patients.engSpringer VerlagArginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSickle cell anemiaArginineArginaseTh17 cellsSoluble adhesion moleculesTGF-βinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15270/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVilas-Boas Arginase levels and ....pdfVilas-Boas Arginase levels and 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| dc.title.pt_BR.fl_str_mv |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| title |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| spellingShingle |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients Vilas-Boas, Wendell Sickle cell anemia Arginine Arginase Th17 cells Soluble adhesion molecules TGF-β |
| title_short |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| title_full |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| title_fullStr |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| title_full_unstemmed |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| title_sort |
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients |
| author |
Vilas-Boas, Wendell |
| author_facet |
Vilas-Boas, Wendell Cerqueira, Bruno Antonio Veloso Zanette, Angela Maria Dias Reis, Mitermayer Galvão dos Barral Netto, Manoel Goncalves, Marilda de Souza |
| author_role |
author |
| author2 |
Cerqueira, Bruno Antonio Veloso Zanette, Angela Maria Dias Reis, Mitermayer Galvão dos Barral Netto, Manoel Goncalves, Marilda de Souza |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Vilas-Boas, Wendell Cerqueira, Bruno Antonio Veloso Zanette, Angela Maria Dias Reis, Mitermayer Galvão dos Barral Netto, Manoel Goncalves, Marilda de Souza |
| dc.subject.en.pt_BR.fl_str_mv |
Sickle cell anemia Arginine Arginase Th17 cells Soluble adhesion molecules TGF-β |
| topic |
Sickle cell anemia Arginine Arginase Th17 cells Soluble adhesion molecules TGF-β |
| description |
Brazilian National Council of Research (CNPq 3065427/2007-5 and 484457/2007-1. Foundation of Research of Bahia (FAPESB; 1431040053063 and 9073/2007) |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
| dc.date.accessioned.fl_str_mv |
2016-08-16T14:11:42Z |
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2016-08-16T14:11:42Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
VILAS-BOAS, W. et al. Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients. Annals of Hematology, v. 89, p. 877–882, 2010. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15270 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0939-5555 |
| dc.identifier.doi.none.fl_str_mv |
10.1007/s00277-010-0954-9 |
| identifier_str_mv |
VILAS-BOAS, W. et al. Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients. Annals of Hematology, v. 89, p. 877–882, 2010. 0939-5555 10.1007/s00277-010-0954-9 |
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https://www.arca.fiocruz.br/handle/icict/15270 |
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eng |
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Springer Verlag |
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Springer Verlag |
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