Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients

Detalhes bibliográficos
Autor(a) principal: Vilas-Boas, Wendell
Data de Publicação: 2010
Outros Autores: Cerqueira, Bruno A. V., Zanette, Angela Maria Dias, Reis, Mitermayer Galvão dos, Barral-Netto, Manoel, Goncalves, Marilda S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5637
Resumo: Acesso restrito: Texto completo. p. 877-882
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spelling Vilas-Boas, WendellCerqueira, Bruno A. V.Zanette, Angela Maria DiasReis, Mitermayer Galvão dosBarral-Netto, ManoelGoncalves, Marilda S.Vilas-Boas, WendellCerqueira, Bruno A. V.Zanette, Angela Maria DiasReis, Mitermayer Galvão dosBarral-Netto, ManoelGoncalves, Marilda S.2012-04-18T17:58:15Z20100939-5555http://www.repositorio.ufba.br/ri/handle/ri/5637v. 89, n. 9Acesso restrito: Texto completo. p. 877-882Sickle cell anemia (SCA) is characterized by a marked endothelial dysfunction, owing to many factors.Arginine metabolism can be related to the inflammatory chronic state presented by patients, playing a key role in their clinical outcome and vascular endothelium. We investigated the serum arginase levels in 50 SCA patients (22 men and 28 women, mean age of 17±10.5 years) and 28 healthy controls. Serum arginase levels were associated with biochemical hemolysis markers and cytokines involved in Th17 response, as well as levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1). Arginase concentrations were higher in SCA patients, compared with controls (p=0.005), and were significantly and positively associated with total bilirubin (p=0.004), indirect bilirubin (p=0.04), and aspartate aminotransferase (AST; p=0.039) in the SCA patient group. Moreover, arginase was significantly and positively associated with transforming growth factor-beta (TGF-beta; p=0.008) among SCA patients. sICAM-1 was significantly and positively associated to reticulocytes (p=0.014) and AST (p=0.04). sVCAM-1 was likewise associated with lactate dehydrogenase (p=0.03). These data suggest a new insight into arginase metabolism, as we show here a shift in arginine catabolism, where TGF-beta may induces the arginase pathway instead of the nitric oxide pathway and a possible involvement of the vascular activation and the serum arginase in chronic hemolysis among SCA patients. Additional studies should be carried out in order to investigate the mechanisms by which TGF-beta participates in the metabolism of arginase in SCA patientsSubmitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-18T17:58:15Z No. of bitstreams: 1 __www.springerlink.com_c...g748685w71903382_fulltext.pdf: 126576 bytes, checksum: 5066ec8320bcd2ede62912f113808ad9 (MD5)Made available in DSpace on 2012-04-18T17:58:15Z (GMT). No. of bitstreams: 1 __www.springerlink.com_c...g748685w71903382_fulltext.pdf: 126576 bytes, checksum: 5066ec8320bcd2ede62912f113808ad9 (MD5) Previous issue date: 2010DOI: 10.1007/s00277-010-0954-9reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASickle cell anemiaArginine . 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dc.title.pt_BR.fl_str_mv Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
dc.title.alternative.pt_BR.fl_str_mv Annals of Hematology
title Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
spellingShingle Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
Vilas-Boas, Wendell
Sickle cell anemia
Arginine . Arginase
Th17 cells
Soluble adhesion molecules
TGF-β
title_short Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
title_full Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
title_fullStr Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
title_full_unstemmed Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
title_sort Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
author Vilas-Boas, Wendell
author_facet Vilas-Boas, Wendell
Cerqueira, Bruno A. V.
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Barral-Netto, Manoel
Goncalves, Marilda S.
author_role author
author2 Cerqueira, Bruno A. V.
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Barral-Netto, Manoel
Goncalves, Marilda S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vilas-Boas, Wendell
Cerqueira, Bruno A. V.
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Barral-Netto, Manoel
Goncalves, Marilda S.
Vilas-Boas, Wendell
Cerqueira, Bruno A. V.
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Barral-Netto, Manoel
Goncalves, Marilda S.
dc.subject.por.fl_str_mv Sickle cell anemia
Arginine . Arginase
Th17 cells
Soluble adhesion molecules
TGF-β
topic Sickle cell anemia
Arginine . Arginase
Th17 cells
Soluble adhesion molecules
TGF-β
description Acesso restrito: Texto completo. p. 877-882
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-04-18T17:58:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5637
dc.identifier.issn.none.fl_str_mv 0939-5555
dc.identifier.number.pt_BR.fl_str_mv v. 89, n. 9
identifier_str_mv 0939-5555
v. 89, n. 9
url http://www.repositorio.ufba.br/ri/handle/ri/5637
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1007/s00277-010-0954-9
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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