Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani

Detalhes bibliográficos
Autor(a) principal: Mazzoni, Camila J.
Data de Publicação: 2006
Outros Autores: Souza, Nataly A., Coelho, Claudia Andrade, Kyriacou, Charalambos P., Peixoto, Alexandre A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39447
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Mazzoni, Camila J.Souza, Nataly A.Coelho, Claudia AndradeKyriacou, Charalambos P.Peixoto, Alexandre A.2020-01-23T11:38:19Z2020-01-23T11:38:19Z2006MAZZONI, Camila J. et al. Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani. BMC Evolutionary Biology, v. 6, n. 85, p. 1-11, Oct. 2006.1471-2148https://www.arca.fiocruz.br/handle/icict/3944710.1186/1471-2148-6-85engBioMed CentralLutzomyia intermediaLutzomyia whitmaniPolimorfismo molecularDiferenciaçãoIntrogressãoGene do períodoLutzomyia intermediaLutzomyia whitmaniMolecular polymorphismDifferentiationIntogressionPeriod geneMolecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmaniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Entomologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Entomologia. Rio de Janeiro, RJ, Brasil.University of Leicester. Department of Genetics. Leicester, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Lutzomyia intermedia and Lutzomyia whitmani (Diptera: Psychodidae) are important and very closely related vector species of cutaneous leishmaniasis in Brazil, which are distinguishable by a few morphological differences. There is evidence of mitochondrial introgression between the two species but it is not clear whether gene flow also occurs in nuclear genes. Results: We analyzed the molecular variation within the clock gene period (per) of these two species in five different localities in Eastern Brazil. AMOVA and Fst estimates showed no evidence for geographical differentiation within species. On the other hand, the values were highly significant for both analyses between species. The two species show no fixed differences and a higher number of shared polymorphisms compared to exclusive mutations. In addition, some haplotypes that are "typical" of one species were found in some individuals of the other species suggesting either the persistence of old polymorphisms or the occurrence of introgression. Two tests of gene flow, one based on linkage disequilibrium and a MCMC analysis based on coalescence, suggest that the two species might be exchanging alleles at the per locus. Conclusion: Introgression might be occurring between L. intermedia and L. whitmani in period, a gene controlling behavioral rhythms in Drosophila. This result raises the question of whether similar phenomena are occurring at other loci controlling important aspects of behavior and vectorial capacity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39447/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCamilaMazzoni_AlexandrePeixoto_etal_IOC_2006.pdfCamilaMazzoni_AlexandrePeixoto_etal_IOC_2006.pdfapplication/pdf708489https://www.arca.fiocruz.br/bitstream/icict/39447/2/CamilaMazzoni_AlexandrePeixoto_etal_IOC_2006.pdfb237471ddfc2f68262f3c8e3171de6dbMD52TEXTCamilaMazzoni_AlexandrePeixoto_etal_IOC_2006.pdf.txtCamilaMazzoni_AlexandrePeixoto_etal_IOC_2006.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
title Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
spellingShingle Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
Mazzoni, Camila J.
Lutzomyia intermedia
Lutzomyia whitmani
Polimorfismo molecular
Diferenciação
Introgressão
Gene do período
Lutzomyia intermedia
Lutzomyia whitmani
Molecular polymorphism
Differentiation
Intogression
Period gene
title_short Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
title_full Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
title_fullStr Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
title_full_unstemmed Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
title_sort Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani
author Mazzoni, Camila J.
author_facet Mazzoni, Camila J.
Souza, Nataly A.
Coelho, Claudia Andrade
Kyriacou, Charalambos P.
Peixoto, Alexandre A.
author_role author
author2 Souza, Nataly A.
Coelho, Claudia Andrade
Kyriacou, Charalambos P.
Peixoto, Alexandre A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mazzoni, Camila J.
Souza, Nataly A.
Coelho, Claudia Andrade
Kyriacou, Charalambos P.
Peixoto, Alexandre A.
dc.subject.other.pt_BR.fl_str_mv Lutzomyia intermedia
Lutzomyia whitmani
Polimorfismo molecular
Diferenciação
Introgressão
Gene do período
topic Lutzomyia intermedia
Lutzomyia whitmani
Polimorfismo molecular
Diferenciação
Introgressão
Gene do período
Lutzomyia intermedia
Lutzomyia whitmani
Molecular polymorphism
Differentiation
Intogression
Period gene
dc.subject.en.pt_BR.fl_str_mv Lutzomyia intermedia
Lutzomyia whitmani
Molecular polymorphism
Differentiation
Intogression
Period gene
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2020-01-23T11:38:19Z
dc.date.available.fl_str_mv 2020-01-23T11:38:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAZZONI, Camila J. et al. Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani. BMC Evolutionary Biology, v. 6, n. 85, p. 1-11, Oct. 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39447
dc.identifier.issn.pt_BR.fl_str_mv 1471-2148
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2148-6-85
identifier_str_mv MAZZONI, Camila J. et al. Molecular polymorphism, differentiation and introgression in the period gene between Lutzomyia intermedia and Lutzomyia whitmani. BMC Evolutionary Biology, v. 6, n. 85, p. 1-11, Oct. 2006.
1471-2148
10.1186/1471-2148-6-85
url https://www.arca.fiocruz.br/handle/icict/39447
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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