Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil

Detalhes bibliográficos
Autor(a) principal: Silva, Walter A. Eyer
Data de Publicação: 2007
Outros Autores: Morgado, Mariza G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44584
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de janeiro, RJ, Brasil / Programa Municipal de HIV-1/ Aids de Saquarema. Saquarema, RJ, Brasil.
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spelling Silva, Walter A. EyerMorgado, Mariza G.2020-11-23T13:47:27Z2020-11-23T13:47:27Z2007SILVA, Walter A. Eyer; MORGADO, Mariza G. Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 809-815, Nov. 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/4458410.1590/S0074-027620070050001121678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.AG - vírus da imunodeficiência humana tipo 1Clusters de transmissãoEpidemiologia molecularBrasilAG - human immunodeficiency virus type 1Molecular epidemiologyTransmission clustersBrazilAutochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de janeiro, RJ, Brasil / Programa Municipal de HIV-1/ Aids de Saquarema. Saquarema, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.As part of an ongoing study on the features of AIDS spread towards small cities and rural areas, we present a molecular survey of human immunodeficiency virus type 1 (HIV-1) polymerase sequences recovered between 2004 and 2006 from 71 patients receiving care in the city of Saquarema, inner state of Rio de Janeiro. Phylogenetic reconstructions found the two prevalent lineages in the state (subtypes B [59 strains, 83.1%], F1 [6 strains; 8.4%], and BF1 recombinants [four strains; 5.6%]), as well as two (2.8%) CRF02_AG strains, which seems to be an emerging lineage in the capital. These CRF02_AG sequences were recovered from a married heterosexual couple who never traveled abroad, thus providing the first molecular evidence of autochthonous horizontal transmission of this lineage of major global importance. Also, three phylogenetic clusters of strains recovered from a total of 18.3% of the cohort were uncovered. Their close genetic relatedness suggests they were recovered from patients who probably took part in the same chain of viral spread. In conjunction with our previous surveys from inner Rio de Janeiro, these results suggest that although small cities harbor unique molecular features of HIV-1 infection, they also clearly reflect and may rapidly absorb the diversity recorded in large urban centers.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44584/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWalterESilva_MarizaMorgado_IOC_2007.pdfWalterESilva_MarizaMorgado_IOC_2007.pdfapplication/pdf210327https://www.arca.fiocruz.br/bitstream/icict/44584/2/WalterESilva_MarizaMorgado_IOC_2007.pdfd8d6f7666dcda2b8a6f990557ec07d83MD52TEXTWalterESilva_MarizaMorgado_IOC_2007.pdf.txtWalterESilva_MarizaMorgado_IOC_2007.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
title Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
spellingShingle Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
Silva, Walter A. Eyer
AG - vírus da imunodeficiência humana tipo 1
Clusters de transmissão
Epidemiologia molecular
Brasil
AG - human immunodeficiency virus type 1
Molecular epidemiology
Transmission clusters
Brazil
title_short Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
title_full Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
title_fullStr Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
title_full_unstemmed Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
title_sort Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil
author Silva, Walter A. Eyer
author_facet Silva, Walter A. Eyer
Morgado, Mariza G.
author_role author
author2 Morgado, Mariza G.
author2_role author
dc.contributor.author.fl_str_mv Silva, Walter A. Eyer
Morgado, Mariza G.
dc.subject.other.pt_BR.fl_str_mv AG - vírus da imunodeficiência humana tipo 1
Clusters de transmissão
Epidemiologia molecular
Brasil
topic AG - vírus da imunodeficiência humana tipo 1
Clusters de transmissão
Epidemiologia molecular
Brasil
AG - human immunodeficiency virus type 1
Molecular epidemiology
Transmission clusters
Brazil
dc.subject.en.pt_BR.fl_str_mv AG - human immunodeficiency virus type 1
Molecular epidemiology
Transmission clusters
Brazil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de janeiro, RJ, Brasil / Programa Municipal de HIV-1/ Aids de Saquarema. Saquarema, RJ, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2020-11-23T13:47:27Z
dc.date.available.fl_str_mv 2020-11-23T13:47:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Walter A. Eyer; MORGADO, Mariza G. Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 809-815, Nov. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44584
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762007005000112
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SILVA, Walter A. Eyer; MORGADO, Mariza G. Autochthonous horizontal transmission of a CRF02_AG strain revealed by a human immunodeficiency virus type 1 diversity survey in a small city in inner State of Rio de Janeiro, Southeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 809-815, Nov. 2007.
0074-0276
10.1590/S0074-02762007005000112
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44584
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language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
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