Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14308 http://dx.doi.org/10.1016/j.toxicon.2013.12.013 |
Resumo: | 2016-12-30 |
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Pontes, Adriana SilvaSetúbal, Sulamita da S.Xavier, Caroline V.Lacouth-Silva, FabianneKayano, Anderson MakotoPires, Weverson LucianoNery, Neriane MonteiroCastro, Onassis Boeri deSilva, Silvana D. daCalderon, Leonardo de AzevedoStábeli, Rodrigo GuerinoSoares, Andreimar MartinsZuliani, Juliana Pavan2016-05-17T13:11:33Z2014PONTES, Adriana Silva et al. Effect of l-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils. Toxicon, v. 80, p. 27-37, 2014.0041-0101https://www.arca.fiocruz.br/handle/icict/14308http://dx.doi.org/10.1016/j.toxicon.2013.12.013engElsevierEffect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophilsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2016-12-30Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brazil. / Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil. / Universidade Federal do Acre. Cruzeiro do Sul, AC, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brazil. / Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brazil. / Faculdade São Lucas. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brazil. / Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho-RO, Brazil. / Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brazil. / Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brazil. / Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho-RO, Brazil. / Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Porto Velho, RO, Brazil. / Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brazil.The in vitro effects of LAAO, an L-amino acid oxidase isolated from Calloselasma rhodosthoma snake venom, on isolated human neutrophil function were investigated. LAAO showed no toxicity on neutrophils. At non-cytotoxic concentrations, LAAO induced the superoxide anion production by isolated human neutrophil. This toxin, in its native form, is also able to stimulate the production of hydrogen peroxide in neutrophils, suggesting that its primary structure is essential for stimulation the cell. Moreover, the incubation of LAAO and phenol red medium did not induce the production of hydrogen peroxide. Furthermore, LAAO was able to stimulate neutrophils to release proinflammatory mediators such as IL-8 and TNF-a as well as NETs liberation. Together, the data showed that the LAAO triggers relevant proinflammatory events. Particular regions of the molecule distinct from the LAAO catalytic site may be involved in the onset of inflammatory events.Snake venomLAAONeutrophilsReactive oxygen speciesCytokinesNETsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14308/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEffect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils.pdfEffect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils.pdfapplication/pdf2260879https://www.arca.fiocruz.br/bitstream/icict/14308/2/Effect%20of%20L-amino%20acid%20oxidase%20from%20Calloselasma%20rhodosthoma%20snake%20venom%20on%20human%20neutrophils.pdfb87b9752d15ab3043aa132706879168bMD52TEXTEffect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils.pdf.txtEffect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils.pdf.txtExtracted texttext/plain57739https://www.arca.fiocruz.br/bitstream/icict/14308/3/Effect%20of%20L-amino%20acid%20oxidase%20from%20Calloselasma%20rhodosthoma%20snake%20venom%20on%20human%20neutrophils.pdf.txt26526eb06778a4981ec5bc2eeb4270efMD53icict/143082021-03-24 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| dc.title.pt_BR.fl_str_mv |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| title |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| spellingShingle |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils Pontes, Adriana Silva Snake venom LAAO Neutrophils Reactive oxygen species Cytokines NETs |
| title_short |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| title_full |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| title_fullStr |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| title_full_unstemmed |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| title_sort |
Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils |
| author |
Pontes, Adriana Silva |
| author_facet |
Pontes, Adriana Silva Setúbal, Sulamita da S. Xavier, Caroline V. Lacouth-Silva, Fabianne Kayano, Anderson Makoto Pires, Weverson Luciano Nery, Neriane Monteiro Castro, Onassis Boeri de Silva, Silvana D. da Calderon, Leonardo de Azevedo Stábeli, Rodrigo Guerino Soares, Andreimar Martins Zuliani, Juliana Pavan |
| author_role |
author |
| author2 |
Setúbal, Sulamita da S. Xavier, Caroline V. Lacouth-Silva, Fabianne Kayano, Anderson Makoto Pires, Weverson Luciano Nery, Neriane Monteiro Castro, Onassis Boeri de Silva, Silvana D. da Calderon, Leonardo de Azevedo Stábeli, Rodrigo Guerino Soares, Andreimar Martins Zuliani, Juliana Pavan |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pontes, Adriana Silva Setúbal, Sulamita da S. Xavier, Caroline V. Lacouth-Silva, Fabianne Kayano, Anderson Makoto Pires, Weverson Luciano Nery, Neriane Monteiro Castro, Onassis Boeri de Silva, Silvana D. da Calderon, Leonardo de Azevedo Stábeli, Rodrigo Guerino Soares, Andreimar Martins Zuliani, Juliana Pavan |
| dc.subject.en.pt_BR.fl_str_mv |
Snake venom LAAO Neutrophils Reactive oxygen species Cytokines NETs |
| topic |
Snake venom LAAO Neutrophils Reactive oxygen species Cytokines NETs |
| description |
2016-12-30 |
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2014 |
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2014 |
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2016-05-17T13:11:33Z |
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info:eu-repo/semantics/article |
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PONTES, Adriana Silva et al. Effect of l-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils. Toxicon, v. 80, p. 27-37, 2014. |
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https://www.arca.fiocruz.br/handle/icict/14308 |
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0041-0101 |
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http://dx.doi.org/10.1016/j.toxicon.2013.12.013 |
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PONTES, Adriana Silva et al. Effect of l-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils. Toxicon, v. 80, p. 27-37, 2014. 0041-0101 |
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https://www.arca.fiocruz.br/handle/icict/14308 http://dx.doi.org/10.1016/j.toxicon.2013.12.013 |
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