Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14314 http://dx.doi.org/10.1155/2014/196754 |
Resumo: | Universidade Federal de Uberlândia. Faculdade de Ciências Integradas do Pontal. Departamento de Genética e Bioquímica. Uberlândia, MG, Brazil. |
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Izidoro, Luiz Fernando M.Sobrinho, Juliana C.Mendes, Mirian M.Costa, Tássia R.Grabner, Amy N.Rodrigues, Veridiana M.Silva, Saulo L. daZanchi, Fernando B.Zuliani, Juliana P.Fernandes, Carla F. C.Calderon, Leonardo A.Stábeli, Rodrigo G.Soares, Andreimar M.2016-05-17T14:23:25Z2016-05-17T14:23:25Z2014SOARES, A.M., et al. Snake venom L-amino acid oxidases: Trends in Pharmacology and Biochemistry. Journal of Biomedicine and Biotechnology (Print), v. 2014, p. 1-19, 2014.https://www.arca.fiocruz.br/handle/icict/14314http://dx.doi.org/10.1155/2014/196754engBioMed Research InternationalSnake venom L-Amino acid oxidases: trends in pharmacology and biochemistryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Uberlândia. Faculdade de Ciências Integradas do Pontal. Departamento de Genética e Bioquímica. Uberlândia, MG, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Universidade Federal de Uberlândia. Faculdade de Ciências Integradas do Pontal. Departamento de Genética e Bioquímica. Uberlândia, MG, Brazil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Universidade Federal de Uberlândia. Faculdade de Ciências Integradas do Pontal. Departamento de Genética e Bioquímica. Uberlândia, MG, Brazil.Universidade Federal de São João del Rei. Departamento de Química, Biotecnologia e Engenharia de Bioprocessos. Ouro Branco, MG, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Centro de Estudos de Biomoléculas Aplicadas à Saúde. Departamento de Medicina. Universidade Federal de Rondônia. Porto Velho, RO, Brazil.L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.Snake VenomL-Amino AcidOxidasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14314/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSnake Venom L-Amino Acid Oxidases Trends in - Pharmacology and Biochemistry.pdfSnake Venom L-Amino Acid Oxidases Trends in - Pharmacology and Biochemistry.pdfapplication/pdf3419937https://www.arca.fiocruz.br/bitstream/icict/14314/2/Snake%20Venom%20L-Amino%20Acid%20Oxidases%20Trends%20in%20-%20Pharmacology%20and%20Biochemistry.pdf77270860cee91bddcc146303c805335cMD52TEXTSnake Venom L-Amino Acid Oxidases Trends in - Pharmacology and Biochemistry.pdf.txtSnake Venom L-Amino Acid Oxidases Trends in - Pharmacology and Biochemistry.pdf.txtExtracted texttext/plain103310https://www.arca.fiocruz.br/bitstream/icict/14314/3/Snake%20Venom%20L-Amino%20Acid%20Oxidases%20Trends%20in%20-%20Pharmacology%20and%20Biochemistry.pdf.txt5be263051b90ebc09e1d5de1618c5e5cMD53icict/143142018-04-02 08:09:21.905oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-02T11:09:21Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.pt_BR.fl_str_mv |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| title |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| spellingShingle |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry Izidoro, Luiz Fernando M. Snake Venom L-Amino Acid Oxidases |
| title_short |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| title_full |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| title_fullStr |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| title_full_unstemmed |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| title_sort |
Snake venom L-Amino acid oxidases: trends in pharmacology and biochemistry |
| author |
Izidoro, Luiz Fernando M. |
| author_facet |
Izidoro, Luiz Fernando M. Sobrinho, Juliana C. Mendes, Mirian M. Costa, Tássia R. Grabner, Amy N. Rodrigues, Veridiana M. Silva, Saulo L. da Zanchi, Fernando B. Zuliani, Juliana P. Fernandes, Carla F. C. Calderon, Leonardo A. Stábeli, Rodrigo G. Soares, Andreimar M. |
| author_role |
author |
| author2 |
Sobrinho, Juliana C. Mendes, Mirian M. Costa, Tássia R. Grabner, Amy N. Rodrigues, Veridiana M. Silva, Saulo L. da Zanchi, Fernando B. Zuliani, Juliana P. Fernandes, Carla F. C. Calderon, Leonardo A. Stábeli, Rodrigo G. Soares, Andreimar M. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Izidoro, Luiz Fernando M. Sobrinho, Juliana C. Mendes, Mirian M. Costa, Tássia R. Grabner, Amy N. Rodrigues, Veridiana M. Silva, Saulo L. da Zanchi, Fernando B. Zuliani, Juliana P. Fernandes, Carla F. C. Calderon, Leonardo A. Stábeli, Rodrigo G. Soares, Andreimar M. |
| dc.subject.en.pt_BR.fl_str_mv |
Snake Venom L-Amino Acid Oxidases |
| topic |
Snake Venom L-Amino Acid Oxidases |
| description |
Universidade Federal de Uberlândia. Faculdade de Ciências Integradas do Pontal. Departamento de Genética e Bioquímica. Uberlândia, MG, Brazil. |
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2014 |
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2014 |
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2016-05-17T14:23:25Z |
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2016-05-17T14:23:25Z |
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SOARES, A.M., et al. Snake venom L-amino acid oxidases: Trends in Pharmacology and Biochemistry. Journal of Biomedicine and Biotechnology (Print), v. 2014, p. 1-19, 2014. |
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https://www.arca.fiocruz.br/handle/icict/14314 |
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http://dx.doi.org/10.1155/2014/196754 |
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SOARES, A.M., et al. Snake venom L-amino acid oxidases: Trends in Pharmacology and Biochemistry. Journal of Biomedicine and Biotechnology (Print), v. 2014, p. 1-19, 2014. |
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https://www.arca.fiocruz.br/handle/icict/14314 http://dx.doi.org/10.1155/2014/196754 |
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BioMed Research International |
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