In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic

Detalhes bibliográficos
Autor(a) principal: Rosa, Rafael B.
Data de Publicação: 2021
Outros Autores: Dantas, Willyenne M., Nascimento, Jessica C. F. do, Silva, Murilo V. da, Oliveira, Ronaldo N. de, Pena, Lindomar J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51174
Resumo: Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil / Federal University of Uberlandia. Rodents Animal Facilities Complex. Uberlandia, MG, Brazil.
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spelling Rosa, Rafael B.Dantas, Willyenne M.Nascimento, Jessica C. F. doSilva, Murilo V. daOliveira, Ronaldo N. dePena, Lindomar J.2022-02-14T14:54:06Z2022-02-14T14:54:06Z2021ROSA, Rafael B. et al. In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic. Viruses, v. 13, p. 1-29, 2021.1999-4915https://www.arca.fiocruz.br/handle/icict/5117410.3390/v13030379engMDPIIn Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemicinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil / Federal University of Uberlandia. Rodents Animal Facilities Complex. Uberlandia, MG, Brazil.Federal Rural University of Pernambuco. Department of Chemistry. Recife, PE, Brazil.Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil.Federal University of Uberlandia. Rodents Animal Facilities Complex. Uberlandia, MG, Brazil.Federal Rural University of Pernambuco. Department of Chemistry. Recife, PE, Brazil.Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil.The emergence and rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in vitro and in vivo models that could be applied in COVID-19 research. In vitro models include two-dimensional (2D) cultures of immortalized cell lines or primary cells and three-dimensional (3D) cultures derived from lung, alveoli, bronchi, and other organs. Although cell-based systems are economic and allow strict control of experimental variables, they do not always resemble physiological conditions. Thus, several in vivo models are being developed, including different strains of mice, hamsters, ferrets, dogs, cats, and non-human primates. In this review, we summarize the main models of SARS-CoV-2 infection developed so far and discuss their advantages, drawbacks and main uses.SARS-CoV-2COVID-19In vivo modelsIn vitro modelsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83088https://www.arca.fiocruz.br/bitstream/icict/51174/1/license.txt7b043faf2a6ad46e5344ca8d54801d8cMD51ORIGINALIn Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic.pdfIn Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic.pdfapplication/pdf1279774https://www.arca.fiocruz.br/bitstream/icict/51174/2/In%20Vitro%20and%20In%20Vivo%20Models%20for%20Studying%20SARS-CoV-2%2c%20the%20Etiological%20Agent%20Responsible%20for%20COVID-19%20Pandemic.pdfec9c01e1fc6238c3bc6e60dbeb2e01a9MD52icict/511742022-03-25 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dc.title.pt_BR.fl_str_mv In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
title In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
spellingShingle In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
Rosa, Rafael B.
SARS-CoV-2
COVID-19
In vivo models
In vitro models
title_short In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
title_full In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
title_fullStr In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
title_full_unstemmed In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
title_sort In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic
author Rosa, Rafael B.
author_facet Rosa, Rafael B.
Dantas, Willyenne M.
Nascimento, Jessica C. F. do
Silva, Murilo V. da
Oliveira, Ronaldo N. de
Pena, Lindomar J.
author_role author
author2 Dantas, Willyenne M.
Nascimento, Jessica C. F. do
Silva, Murilo V. da
Oliveira, Ronaldo N. de
Pena, Lindomar J.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rosa, Rafael B.
Dantas, Willyenne M.
Nascimento, Jessica C. F. do
Silva, Murilo V. da
Oliveira, Ronaldo N. de
Pena, Lindomar J.
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
In vivo models
In vitro models
topic SARS-CoV-2
COVID-19
In vivo models
In vitro models
description Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology. Recife, PE, Brazil / Federal University of Uberlandia. Rodents Animal Facilities Complex. Uberlandia, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-14T14:54:06Z
dc.date.available.fl_str_mv 2022-02-14T14:54:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROSA, Rafael B. et al. In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic. Viruses, v. 13, p. 1-29, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51174
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/v13030379
identifier_str_mv ROSA, Rafael B. et al. In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic. Viruses, v. 13, p. 1-29, 2021.
1999-4915
10.3390/v13030379
url https://www.arca.fiocruz.br/handle/icict/51174
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51174/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51174/2/In%20Vitro%20and%20In%20Vivo%20Models%20for%20Studying%20SARS-CoV-2%2c%20the%20Etiological%20Agent%20Responsible%20for%20COVID-19%20Pandemic.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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