Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24863 |
Resumo: | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil |
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Espíndola, Milena SobralLima, Leonardo Judson Galvão deSoares, Luana SilvaCacemiro, Maira da CostaZambuzi, Fabiana AlbaniGomes, Matheus de SouzaAmaral, Laurence Rodrigues doBollela, Valdes RobertoMartins Filho, Olindo AssisFrantz, Fabiani Gai2018-02-16T16:08:25Z2018-02-16T16:08:25Z2015ESPÍNDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS ONE, v. 10, n. 12, e0145261, 20151932-6203https://www.arca.fiocruz.br/handle/icict/2486310.1371/journal.pone.0145261engPublic Library of Scienceterapias antiretroviralbiomarcadoresHIVHighly-active antiretroviral therapyBiomarkersHIVCytokinesT cellsInflammatory diseasesViral loadDecision treesDysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, BrazilUniversidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, BrazilUniversidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, BrazilUniversidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, BrazilUniversidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, BrazilUniversidade Federal de Uberlandia. Laboratorio de Bioinformatica e Analises Moleculares. Patos de Minas, MG, BrazilUniversidade Federal de Uberlandia. Laboratorio de Bioinformatica e Analises Moleculares. Patos de Minas, MG, BrazilUniversidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Ribeirao Preto, SP, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores para Diagnostico e Monitoramento, Belo Horizonte, MG, BrazilUniversidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, BrazilBackground:Successful highly active antiretroviral therapy (HAART) has changed the outcome of AIDS patients worldwide because the complete suppression of viremia improves health and prolongs life expectancy of HIV-1+ patients. However, little attention has been given to the immunological profile of patients under distinct HAART regimens. This work aimed to investigate the differences in the immunological pattern of HIV-1+ patients under the first- or second-line HAART in Brazil. Methods:CD4+ T cell counts, Viral load, and plasma concentration of sCD14, sCD163, MCP-1, RANTES, IP-10, IL-1β, IL-6, TNF-α, IL-12, IFN-α, IFN-γ, IL-4, IL-5, and IL-10 were assessed for immunological characterization of the following clinical groups: Non-infected individuals (NI; n = 66), HIV-1+ untreated (HIV; n = 46), HIV-1+ treated with first-line HAART (HAART 1; n = 15); and HIV-1+ treated with second-line HAART (HAART 2; n = 15). Results:We found that the immunological biosignature pattern of HAART 1 is similar to that of NI individuals, especially in patients presenting slow progression of the disease, while patients under HAART 2 remain in a moderate inflammatory state, which is similar to that of untreated HIV patients pattern. Network correlations revealed that differences in IP-10, TNF-α, IL-6, IFN-α, and IL-10 interactions were primordial in HIV disease and treatment. Heat map and decision tree analysis identified that IP-10>TNF-α>IFN-α were the best respective HAART segregation biomarkers. Conclusion:HIV patients in different HAART regimens develop distinct immunological biosignature, introducing a novel perspective into disease outcome and potential new therapies that consider HAART patients as a heterogeneous group.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/24863/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients.pdfDysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients.pdfapplication/pdf2871246https://www.arca.fiocruz.br/bitstream/icict/24863/2/Dysregulated%20Immune%20Activation%20in%20Second-Line%20HAART%20HIV%2b%20Patients%20Is%20Similar%20to%20That%20of%20Untreated%20Patients.pdf87ba42d13350c2b2d182b1adca93d6c4MD52TEXTDysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients.pdf.txtDysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients.pdf.txtExtracted texttext/plain54742https://www.arca.fiocruz.br/bitstream/icict/24863/3/Dysregulated%20Immune%20Activation%20in%20Second-Line%20HAART%20HIV%2b%20Patients%20Is%20Similar%20to%20That%20of%20Untreated%20Patients.pdf.txt66eaccdeff518f138e737c8617e18aabMD53icict/248632019-06-19 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| dc.title.pt_BR.fl_str_mv |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| title |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| spellingShingle |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients Espíndola, Milena Sobral terapias antiretroviral biomarcadores HIV Highly-active antiretroviral therapy Biomarkers HIV Cytokines T cells Inflammatory diseases Viral load Decision trees |
| title_short |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| title_full |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| title_fullStr |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| title_full_unstemmed |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| title_sort |
Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients |
| author |
Espíndola, Milena Sobral |
| author_facet |
Espíndola, Milena Sobral Lima, Leonardo Judson Galvão de Soares, Luana Silva Cacemiro, Maira da Costa Zambuzi, Fabiana Albani Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Bollela, Valdes Roberto Martins Filho, Olindo Assis Frantz, Fabiani Gai |
| author_role |
author |
| author2 |
Lima, Leonardo Judson Galvão de Soares, Luana Silva Cacemiro, Maira da Costa Zambuzi, Fabiana Albani Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Bollela, Valdes Roberto Martins Filho, Olindo Assis Frantz, Fabiani Gai |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Espíndola, Milena Sobral Lima, Leonardo Judson Galvão de Soares, Luana Silva Cacemiro, Maira da Costa Zambuzi, Fabiana Albani Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Bollela, Valdes Roberto Martins Filho, Olindo Assis Frantz, Fabiani Gai |
| dc.subject.other.pt_BR.fl_str_mv |
terapias antiretroviral biomarcadores HIV |
| topic |
terapias antiretroviral biomarcadores HIV Highly-active antiretroviral therapy Biomarkers HIV Cytokines T cells Inflammatory diseases Viral load Decision trees |
| dc.subject.en.pt_BR.fl_str_mv |
Highly-active antiretroviral therapy Biomarkers HIV Cytokines T cells Inflammatory diseases Viral load Decision trees |
| description |
Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil |
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2015 |
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2015 |
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2018-02-16T16:08:25Z |
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2018-02-16T16:08:25Z |
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info:eu-repo/semantics/article |
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ESPÍNDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS ONE, v. 10, n. 12, e0145261, 2015 |
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https://www.arca.fiocruz.br/handle/icict/24863 |
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1932-6203 |
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10.1371/journal.pone.0145261 |
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ESPÍNDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS ONE, v. 10, n. 12, e0145261, 2015 1932-6203 10.1371/journal.pone.0145261 |
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