Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients

Detalhes bibliográficos
Autor(a) principal: Espindola, Milena Sobral
Data de Publicação: 2015
Outros Autores: Lima, Leonardo Judson Galvão de, Soares, Luana Silva, Cacemiro, Maira da Costa, Zambuzi, Fabiana A Albani, Gomes, Matheus de Souza, Amaral, Laurence Rodrigues, Bollela, Valdes Roberto, Martins Filho, Olindo Assis, Frantz, Fabiani G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15083
Resumo: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.
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spelling Espindola, Milena SobralLima, Leonardo Judson Galvão deSoares, Luana SilvaCacemiro, Maira da CostaZambuzi, Fabiana A AlbaniGomes, Matheus de SouzaAmaral, Laurence RodriguesBollela, Valdes RobertoMartins Filho, Olindo AssisFrantz, Fabiani G.2016-07-08T19:23:26Z2016-07-22T13:23:08Z2016-07-08T19:23:26Z2016-07-22T13:23:08Z2015ESPINDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS One, v. 10, n. 12, p. 1-17, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1508310.1371/journal.pone.0145261engPublic Library of ScienceDysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brasil.Universidade Federal de Uberlândia. Laboratório de Bioinformática e Análises Moleculares. Patos de Minas, MG, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Biomarcadores para Diagnostico e Monitoramento. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.BACKGROUND: Successful highly active antiretroviral therapy (HAART) has changed the outcome of AIDS patients worldwide because the complete suppression of viremia improves health and prolongs life expectancy of HIV-1+ patients. However, little attention has been given to the immunological profile of patients under distinct HAART regimens. This work aimed to investigate the differences in the immunological pattern of HIV-1+ patients under the first- or second-line HAART in Brazil. METHODS: CD4+ T cell counts, Viral load, and plasma concentration of sCD14, sCD163, MCP-1, RANTES, IP-10, IL-1β, IL-6, TNF-α, IL-12, IFN-α, IFN-γ, IL-4, IL-5, and IL-10 were assessed for immunological characterization of the following clinical groups: Non-infected individuals (NI; n = 66), HIV-1+ untreated (HIV; n = 46), HIV-1+ treated with first-line HAART (HAART 1; n = 15); and HIV-1+ treated with second-line HAART (HAART 2; n = 15). RESULTS: We found that the immunological biosignature pattern of HAART 1 is similar to that of NI individuals, especially in patients presenting slow progression of the disease, while patients under HAART 2 remain in a moderate inflammatory state, which is similar to that of untreated HIV patients pattern. Network correlations revealed that differences in IP-10, TNF-α, IL-6, IFN-α, and IL-10 interactions were primordial in HIV disease and treatment. Heat map and decision tree analysis identified that IP-10>TNF-α>IFN-α were the best respective HAART segregation biomarkers. CONCLUSION: HIV patients in different HAART regimens develop distinct immunological biosignature, introducing a novel perspective into disease outcome and potential new therapies that consider HAART patients as a heterogeneous group.Antiretroviral TherapyHighly ActiveDisease ProgressionHIV Infections/immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTve_Espindola_Milena_ Dysregulated_CPqRR_2015.PDF.txtve_Espindola_Milena_ Dysregulated_CPqRR_2015.PDF.txtExtracted texttext/plain54746https://www.arca.fiocruz.br/bitstream/icict/15083/4/ve_Espindola_Milena_%20Dysregulated_CPqRR_2015.PDF.txt58738f3da9d5723ee829eddbd428183bMD54ORIGINALve_Espindola_Milena_ 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dc.title.pt_BR.fl_str_mv Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
title Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
spellingShingle Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
Espindola, Milena Sobral
Antiretroviral Therapy
Highly Active
Disease Progression
HIV Infections/immunology
title_short Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
title_full Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
title_fullStr Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
title_full_unstemmed Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
title_sort Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients
author Espindola, Milena Sobral
author_facet Espindola, Milena Sobral
Lima, Leonardo Judson Galvão de
Soares, Luana Silva
Cacemiro, Maira da Costa
Zambuzi, Fabiana A Albani
Gomes, Matheus de Souza
Amaral, Laurence Rodrigues
Bollela, Valdes Roberto
Martins Filho, Olindo Assis
Frantz, Fabiani G.
author_role author
author2 Lima, Leonardo Judson Galvão de
Soares, Luana Silva
Cacemiro, Maira da Costa
Zambuzi, Fabiana A Albani
Gomes, Matheus de Souza
Amaral, Laurence Rodrigues
Bollela, Valdes Roberto
Martins Filho, Olindo Assis
Frantz, Fabiani G.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Espindola, Milena Sobral
Lima, Leonardo Judson Galvão de
Soares, Luana Silva
Cacemiro, Maira da Costa
Zambuzi, Fabiana A Albani
Gomes, Matheus de Souza
Amaral, Laurence Rodrigues
Bollela, Valdes Roberto
Martins Filho, Olindo Assis
Frantz, Fabiani G.
dc.subject.en.pt_BR.fl_str_mv Antiretroviral Therapy
Highly Active
Disease Progression
HIV Infections/immunology
topic Antiretroviral Therapy
Highly Active
Disease Progression
HIV Infections/immunology
description Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-07-08T19:23:26Z
2016-07-22T13:23:08Z
dc.date.available.fl_str_mv 2016-07-08T19:23:26Z
2016-07-22T13:23:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESPINDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS One, v. 10, n. 12, p. 1-17, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15083
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pone.0145261
identifier_str_mv ESPINDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS One, v. 10, n. 12, p. 1-17, 2015.
1932-6203
10.1371/journal.pone.0145261
url https://www.arca.fiocruz.br/handle/icict/15083
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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