Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)

Detalhes bibliográficos
Autor(a) principal: Campos, Rozalia Mendes Figueira
Data de Publicação: 2004
Outros Autores: Guerreiro, Marcos Lázaro da Silva, Sobral, Karina de Souza Castro, Lima, Rita de Cássia P. Cunha, Andrade, Sonia Gumes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/2822
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil.
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spelling Campos, Rozalia Mendes FigueiraGuerreiro, Marcos Lázaro da SilvaSobral, Karina de Souza CastroLima, Rita de Cássia P. CunhaAndrade, Sonia Gumes2011-08-31T13:13:58Z2011-08-31T13:13:58Z2004CAMPOS, R. F. et al. Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II). Revista da Sociedade Brasileira de Medicina Tropical, v. 38, n. 2, p. 142-146, 2005.0037-8682https://www.arca.fiocruz.br/handle/icict/2822engAnimaisDoença de ChagasCamundongosNitroimidazóisParasitemiaFatores de TempoTripanossomicidasTrypanosoma cruziTrypanosoma cruziTrypanosoma cruzi IIBiodema Tipo IIClonesBenzonidazolQuimioterapiaDoença de ChagasNitroimidazóisParasitemiaTripanossomicidasTrypanosoma cruziFatores de TempoResponse to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.A suscetibilidade à quimioterapia com o benzonidazol, de 5 clones isolados da cepa 21SF (biodema Tipo II, T. cruzi II), foi investigada. Camundongos suíços foram infectados com a cepa parental e com cada clone e submetidos à quimioterapia com benzonidazol (100mg/k/dia durante 90 dias). Os índices de cura foram avaliados pelos testes de cura parasitológicos. A sorologia foi avaliada para os animais tratados e (de negativo a 1: 640) e para os controles não tratados( 1:160 a 1:640). Os índices de cura variaram de 30% a 100% para os 5 clones sendo de 25% para a cepa parental. Os resultados sugerem que a variabilidade de resposta ao tratamento das populações clonais das cepas Trypanosoma cruzi II é responsável pela grande variação na resposta à quimioterapia com benzonidazol e nifurtimox das cepas deste biodemainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCampos RF Response to chemotherapy with....pdfCampos RF Response to chemotherapy with....pdfapplication/pdf45008https://www.arca.fiocruz.br/bitstream/icict/2822/1/Campos%20RF%20Response%20to%20chemotherapy%20with....pdfec08f7c1368b69e5fae915249d77be1eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2822/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCampos RF Response to chemotherapy with....pdf.txtCampos RF Response to chemotherapy with....pdf.txtExtracted texttext/plain21547https://www.arca.fiocruz.br/bitstream/icict/2822/5/Campos%20RF%20Response%20to%20chemotherapy%20with....pdf.txt5516cc36cffa8a19896c531e1e380150MD55THUMBNAILCampos RF Response to chemotherapy with....pdf.jpgCampos RF Response to chemotherapy with....pdf.jpgGenerated Thumbnailimage/jpeg2268https://www.arca.fiocruz.br/bitstream/icict/2822/4/Campos%20RF%20Response%20to%20chemotherapy%20with....pdf.jpg042e7b34fdd47e01a54776d00633f12bMD54icict/28222023-03-15 14:33:55.198oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
title Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
spellingShingle Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
Campos, Rozalia Mendes Figueira
Animais
Doença de Chagas
Camundongos
Nitroimidazóis
Parasitemia
Fatores de Tempo
Tripanossomicidas
Trypanosoma cruzi
Trypanosoma cruzi
Trypanosoma cruzi II
Biodema Tipo II
Clones
Benzonidazol
Quimioterapia
Doença de Chagas
Nitroimidazóis
Parasitemia
Tripanossomicidas
Trypanosoma cruzi
Fatores de Tempo
title_short Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
title_full Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
title_fullStr Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
title_full_unstemmed Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
title_sort Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II)
author Campos, Rozalia Mendes Figueira
author_facet Campos, Rozalia Mendes Figueira
Guerreiro, Marcos Lázaro da Silva
Sobral, Karina de Souza Castro
Lima, Rita de Cássia P. Cunha
Andrade, Sonia Gumes
author_role author
author2 Guerreiro, Marcos Lázaro da Silva
Sobral, Karina de Souza Castro
Lima, Rita de Cássia P. Cunha
Andrade, Sonia Gumes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Campos, Rozalia Mendes Figueira
Guerreiro, Marcos Lázaro da Silva
Sobral, Karina de Souza Castro
Lima, Rita de Cássia P. Cunha
Andrade, Sonia Gumes
dc.subject.other.pt_BR.fl_str_mv Animais
Doença de Chagas
Camundongos
Nitroimidazóis
Parasitemia
Fatores de Tempo
Tripanossomicidas
Trypanosoma cruzi
topic Animais
Doença de Chagas
Camundongos
Nitroimidazóis
Parasitemia
Fatores de Tempo
Tripanossomicidas
Trypanosoma cruzi
Trypanosoma cruzi
Trypanosoma cruzi II
Biodema Tipo II
Clones
Benzonidazol
Quimioterapia
Doença de Chagas
Nitroimidazóis
Parasitemia
Tripanossomicidas
Trypanosoma cruzi
Fatores de Tempo
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Trypanosoma cruzi II
Biodema Tipo II
Clones
Benzonidazol
Quimioterapia
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas
Nitroimidazóis
Parasitemia
Tripanossomicidas
Trypanosoma cruzi
Fatores de Tempo
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2011-08-31T13:13:58Z
dc.date.available.fl_str_mv 2011-08-31T13:13:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS, R. F. et al. Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II). Revista da Sociedade Brasileira de Medicina Tropical, v. 38, n. 2, p. 142-146, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/2822
dc.identifier.issn.none.fl_str_mv 0037-8682
identifier_str_mv CAMPOS, R. F. et al. Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II). Revista da Sociedade Brasileira de Medicina Tropical, v. 38, n. 2, p. 142-146, 2005.
0037-8682
url https://www.arca.fiocruz.br/handle/icict/2822
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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