Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2826 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. |
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Garcia, SimoneRamos, Carolina OSenra, Juliana Fraga VasconcelosVilas-Boas, FábioRodrigues, Maurício MartinsCarvalho, Antonio Carlos Campos deSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2011-08-31T13:50:29Z2011-08-31T13:50:29Z2005GARCIA, S. et al. Treatment with Benznidazole during the Chronic Phase of Experimental Chagas Disease Decreases Cardiac Alterations. Antimicrobial Agents Chemotherapy, v.49, n.4, p.1521-8, 2005.1098-6596https://www.arca.fiocruz.br/handle/icict/2826doi:10.1128/AAC.49.4.1521–1528.2005engAnimaisDoença de ChagasCamundongosNitroimidazóisParasitemiaFatores de TempoTripanossomicidasTrypanosoma CruziTreatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Hospital Santa Izabel. Salvador, Bahia, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil.Chagas’ disease, caused by Trypanosoma cruzi infection, is one of the main causes of death due to heart failure in Latin American countries. Benznidazole, the chemotherapeutic agent most often used for the treatment of chagasic patients, is highly toxic and has limited efficacy, especially in the chronic phase of the disease. In the present study we used a mouse model of chronic Chagas’ disease to investigate the effects of benznidazole treatment during the chronic phase on disease progression. The hearts of benznidazole-treated mice had decreased parasitism and myocarditis compared to the hearts of untreated chagasic mice. Both groups of Trypanosoma cruzi-infected mice had significant alterations in their electrocardiograms compared to those of the healthy mice. However, untreated mice had significantly higher cardiac conduction disturbances than benznidazole-treated mice, including intraventricular conduction disturbances, atrioventricular blocks, and extrasystoles. The levels of antibodies against T. cruzi antigens (epimastigote extract, P2 , and transsialidase) as well as antibodies against peptides of the second extracellular loops of 1-adrenergic and M2-muscarinic cardiac receptors were also lower in the sera from benznidazole-treated mice than in the sera from untreated mice. These results demonstrate that treatment with benznidazole in the chronic phase of infection prevents the development of severe chronic cardiomyopathy, despite the lack of complete parasite eradication. In addition, our data highlight the role of parasite persistence in the development of chronic Chagas’ disease and reinforce the importance of T. cruzi elimination in order to decrease or prevent the development of severe chagasic cardiomyopathy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGarcia S Treatment with benznidazole....pdfGarcia S Treatment with benznidazole....pdfapplication/pdf514129https://www.arca.fiocruz.br/bitstream/icict/2826/1/Garcia%20S%20Treatment%20with%20benznidazole....pdfe9ee9c0b9c3aa3a524b3cbde09ff8bb7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2826/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTGarcia S Treatment with benznidazole....pdf.txtGarcia S Treatment with benznidazole....pdf.txtExtracted texttext/plain39533https://www.arca.fiocruz.br/bitstream/icict/2826/5/Garcia%20S%20Treatment%20with%20benznidazole....pdf.txtc1b1ae0277c5e7057073c3628ab4ddacMD55THUMBNAILGarcia S Treatment with benznidazole....pdf.jpgGarcia S Treatment with benznidazole....pdf.jpgGenerated Thumbnailimage/jpeg2223https://www.arca.fiocruz.br/bitstream/icict/2826/4/Garcia%20S%20Treatment%20with%20benznidazole....pdf.jpgef9fa4e5811a983cd5197c925b184499MD54icict/28262023-03-15 14:33:26.468oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| title |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| spellingShingle |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations Garcia, Simone Animais Doença de Chagas Camundongos Nitroimidazóis Parasitemia Fatores de Tempo Tripanossomicidas Trypanosoma Cruzi |
| title_short |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| title_full |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| title_fullStr |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| title_full_unstemmed |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| title_sort |
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas’ Disease Decreases Cardiac Alterations |
| author |
Garcia, Simone |
| author_facet |
Garcia, Simone Ramos, Carolina O Senra, Juliana Fraga Vasconcelos Vilas-Boas, Fábio Rodrigues, Maurício Martins Carvalho, Antonio Carlos Campos de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Ramos, Carolina O Senra, Juliana Fraga Vasconcelos Vilas-Boas, Fábio Rodrigues, Maurício Martins Carvalho, Antonio Carlos Campos de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Garcia, Simone Ramos, Carolina O Senra, Juliana Fraga Vasconcelos Vilas-Boas, Fábio Rodrigues, Maurício Martins Carvalho, Antonio Carlos Campos de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Animais Doença de Chagas Camundongos Nitroimidazóis Parasitemia Fatores de Tempo Tripanossomicidas Trypanosoma Cruzi |
| topic |
Animais Doença de Chagas Camundongos Nitroimidazóis Parasitemia Fatores de Tempo Tripanossomicidas Trypanosoma Cruzi |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil. |
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2005 |
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2005 |
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2011-08-31T13:50:29Z |
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2011-08-31T13:50:29Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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GARCIA, S. et al. Treatment with Benznidazole during the Chronic Phase of Experimental Chagas Disease Decreases Cardiac Alterations. Antimicrobial Agents Chemotherapy, v.49, n.4, p.1521-8, 2005. |
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doi:10.1128/AAC.49.4.1521–1528.2005 |
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GARCIA, S. et al. Treatment with Benznidazole during the Chronic Phase of Experimental Chagas Disease Decreases Cardiac Alterations. Antimicrobial Agents Chemotherapy, v.49, n.4, p.1521-8, 2005. 1098-6596 doi:10.1128/AAC.49.4.1521–1528.2005 |
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